Trusted Partner
We’re excited to introduce 1-MNA, a breakthrough molecule that works at the cellular level to reduce inflammation and enhance recovery. Thanks to our partnership with European researchers, the dietary supplement Endotelio 1-MNA is now accessible in the US market. Researched extensively for its safety profile, 1-MNA supplementation aims to safely restore NAD levels, optimize cellular redox pathways, and combat age-related diseases comprehensively. Simply put, unlike other NAD supplements, 1-MNA offers a safe and effective way to restore NAD levels for health while maintaining Redox homeostasis. With its high safety profile, 1-MNA is perfect for everyday use to maintain health or can be used to address inflammatory and metabolic disorders.
What is 1-MNA?
1-MNA, short for 1-methyl nicotinamide, is a natural compound produced in the body through the breakdown of niacin, a form of vitamin B3. Research indicates that supplementing with 1-MNA can offer benefits for inflammatory conditions, oxidative stress-related issues, and overall health. It aids in reducing inflammation, improving recovery, and safeguarding against cardiac disorders. By regulating mitochondrial function, 1-MNA helps maintain energy balance and promotes bodily equilibrium, making it beneficial for many age-related health conditions such as obesity, metabolic syndrome, cardiac disease, liver disease, cancer, and post-COVID fatigue.
As we age, our body’s ability to produce NAD decreases, leading to a decline in levels of the coenzymes NAD+ and NADP+, which are crucial for cellular processes. This decline starts around age 30, with NAD+ levels dropping by up to 50% between ages 40 and 60. Lower NAD+ levels result in slower cell regeneration and contribute to the aging process.
1-MNA offers a promising solution to this decline by optimizing NAD+ levels. The molecule is derived from vitamins and naturally present in the human body.
1-MNA effectively restores healthy NAD+ levels by inhibiting the nicotinamide N-methyltransferase (NNMT) enzyme. Additionally, it enhances the activity of SIRT1 and NRF2, reduces oxidative stress, and blocks inflammation by inhibiting Nuclear factor kappa beta (NF-κB).
1-MNA’s Role In NAD Regulation
NAD is crucial for energy production in the body’s cells. However, as we age, NAD levels decline, partly due to increased activity of NNMT enzymes, which degrade NAD. Simply supplementing with NAD or its precursors without addressing NNMT activity may not be effective, and may even be detrimental, as damaged cells, such as senescent, cancer, or adipose cells, upregulate NNMT and degrade NAD for their own benefit. Extensive research is being done investigating the use of NNMT blockers for helping in metabolic diseases, muscle loss, unregulated cell growth, and cardiovascular disorders. 1-MNA acts as a novel NNMT regulator, preventing the degradation of NAD and thus maintaining optimal NAD levels. Research indicates that high NNMT levels are associated with various metabolic diseases, weight gain, and cancer.
Sources of 1-MNA
1-MNA is a compound naturally produced in our bodies, primarily in the liver, as it’s a byproduct of nicotinic acid and nicotinamide metabolism. While it’s also found in vitamin B3-rich foods, dietary sources contribute minimally to the total amount of 1-MNA present in the human body. In fact, around 16% of the niacin we consume is transformed into 1-MNA, as cited by Menon et al., 2007.
Some foods that are notable for their 1-MNA content, as reported by Taguchi et al., 1986, include:
- Undaria pinnatifida (Wakame seaweed): 3.2 mg per 100g
- Green tea leaves: 3.0 mg per 100g
- Chicken gizzards: 2.4 mg per 100g
- Celery: 1.6 mg per 100g
- Chinese black mushrooms: 1.3 mg per 100g
1-MNA Safety
1-MNA, a physiological substance with vitamin origins, is also found in natural sources. Research has consistently shown that 1-MNA is both safe and well-tolerated in humans. The European Food Safety Authority (EFSA) has conducted a thorough assessment of 1-MNA’s safety, confirming its safe usage(1).
(1) EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D, et al. “Scientific Opinion: Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97.” EFSA Journal 2017; 15(10): 5001.
Ingredients and Recommended Use
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
SSRP Member Discounts
Your SSRP Membership qualifies you for additional savings on your wholesale orders of 1-MNA.
Visit 1mna.com, create an account or login, and enter the code SSRP-PARTNER-24 to receive up to 55% off MSRP pricing.
Contact
For any questions, please call 360-854-3508 or email support@1mna.com.
To learn more, find a link to Research and Studies after logging in to your account:
