Hi Angeli
Below are a few notes from the book Estrogen Matters. Hope it helps.
CVA Risk
– Premenopausal women have a lower risk of stroke than men of the same age and that after menopause a women’s annual risk of stroke increases exponentially.
– Younger women deprived of estrogen are also at increased risk of stroke.
– Stanley Birge, director of Older Adult Health Center at Washington University School of Medicine in St Louis, laments the belief that “persists in advising against the use of hormone therapy for prevention of cardiovascular disease and osteoporosis” on the grounds that hormones increase risk of stroke. The WHI data is misinterpreted. WHI population was older than 65yo, overweight, hypertensive and smokers, and thus had some degree of atherosclerotic disease.
– 2015 Cochrane analysis by Henry Boardman of the dept of cardiovascular medicine at Oxford University found no increased risk of stroke among women who started taking hormones before age sixty.
Bone Health
– Bone is formed until age 30. Over the next decade, bone formation remains steady. At forty bone formation slowly declines. After fifty bone loss is greater than bone formation.
– HRT is the most effective intervention at preventing osteoporosis or diminishing the development of osteoporosis
– Postmenopausal women taking estrogen have a 50% reduction in the likelihood of having a fracture
– For estrogen to reduce the risk of fracture that occurs ten to 30 years after menopause, postmenopausal women must remain on HRT. When women go off estrogen, after six years the risk of hip fracture is where it would have been had they never taken hormones
– Women over the age of fifty have four times the rate of osteoporosis than men
– 25% of patients older than 70 who have a hip fracture will die within a year. If you survive the first year, women lost an average of 3.75 years of life.
Seth
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