Video Library
Tune in every Monday for our exclusive video series, Cellular Medicine Mondays, including multiple episode types that review community questions, published white papers, popular protocols, and hot topics on Dr. Seeds’ mind.
Dr. Seeds’ Office Hours – Episode 108
Questions Answered:
1. ARA-290 for Post Op 47yo Male [0:53]
2. Cold Therapy and the Wim Hof Method [17:06]
Mini Anti-Aging Mastermind Part 1: Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging
Part 1 of a special Mini Anti-Aging Mastermind inspired by the recent Science article exploring how impaired clearance of senescent neutrophils may contribute to age-related organ decline. Dr. Seeds begins breaking down the cellular mechanisms behind the research and what they reveal about the biology of aging. (Article Link)
Peptide Support After Transplant: What to Consider First
Dr. Seeds explores how to protect graft integrity and identify the right cellular targets before considering peptide support in a patient six years post liver transplant.
Dr. Seeds’ Office Hours – Episode 105
Phenotyping is Essential to Cellular Medicine
In this episode of Rabbit Holes, Dr. Seeds breaks down why phenotyping is essential to Cellular Medicine. Understanding the individual patient allows for more precise, personalized care instead of guessing or relying on random peptide protocols.
Liposomal Peptides
Dr. Seeds takes a closer look at liposomal peptides, including Epitalon, BPC-157, TB4, KPV, and GHK-Cu, and examines the claims around sourcing, stability, absorption, bioavailability, injection fatigue, and whether these formulations can truly compare to injectable peptides.
Office Hours PWC26 Virtual Summit Part 4- Episode 102
- Compounded topical creams and GHK-Cu with microneedling (0:59)
- Detoxing before using copper (12:09)
- Patient onboarding process (12:54)
- Zinc and iron supplementation with GHK-Cu (23:41)
- Loss of taste after COVID (25:55)
- 3D CT scans for root canals (27:03)
- Oral bacteria swabs and GLP-1 effectiveness (28:00)
- Endocannabinoid system (29:07)
- GHK-Cu efficacy on wound beds (32:05)
Office Hours PWC26 Virtual Summit Part 3 – Episode 101
1. Mitochondrial peptides (1:07)
2. MOTS-c cycle (3:50)
3. Injury site specific injection (9:25)
4. BPC-157 dosing (15:18)
5. Trusted labs (20:56)
6. What “redox” means (25:48)
7. Patient with cervical fusion, pain, and decreased range of motion (31:36)
8. Lipedema (37:03)
9. SS-31 and MOTS-c (37:52)
10. NanoVI device (44:49)
11. NAD (48:13)
Office Hours PWC26 Virtual Summit Part 2 – Episode 100
- Evaluating terrain of the patient (1:43)
- SS31 peptide in practice (8:50)
- Phenotyping the right patient for GLP-1 therapy (11:18)
Office Hours: PWC26 Virtual Summit Part 1 – Episode 099
This special edition of Office Hours features questions submitted during the Peptide World Congress Virtual Summit on July 10 and 11. Dr. Seeds and Dr. Newman address:
- GLOW Stack, MOTS c, and Thyroid Function (0:50)
- Should the GLOW Stack Be Separated? (3:31)
- Peptides in Transplant Medicine (8:02)
- Biomarker Monitoring (13:21)
- Peptides in Acute and Long Term Stroke Recovery (17:37)
- Autoimmunity and the GI Tract (23:00)
- Cancer Concerns Related to Hormones and Angiogenesis (26:49)
Pentosan Polysulfate: Dosing, Safety, and Monitoring
Dr. Seeds examines the subcutaneous use of pentosan polysulfate, addressing concerns about injection site scarring and ocular safety. He discusses dosing, site rotation, cumulative exposure, retinal screening, and strategies for responsible, individualized treatment.(Question Link)
Creatine: Evidence, Pathways, and Hype
Dr. Seeds examines creatine through a cellular medicine lens, separating evidence-supported uses in ATP buffering, performance, and methylation from claims that exceed current clinical data.
Efficient Generation of Pancreatic Progenitor Cells from Induced Pluripotent Stem Cells Derived from a Non-Invasive and Accessible Tissue Source—The Plucked Hair Follicle
Dr. Seeds reviews how cryopreserved hair follicles may offer a simpler, non-invasive source for future stem cell research and pancreatic cell development. (Article Link)
Dr. Seeds’ Office Hours – Episode 095
1. Sjögren’s, POTS, Mold, Biofilms & Lumbrokinase (0:45)
2. PMDD, Allopregnanolone & Mitochondrial Efficiency (7:28)
3. Retatrutide, Glucagon & Metabolic Flexibility (20:01)
Cellular Optimization for EDS Surgical Support
Dr. Seeds reviews peptide and supplemental considerations for cellular optimization in an EDS patient preparing for orthopedic surgery. (Question Link)
The Phosphatidylcholine Pathway
Dr. Seeds expands on Journal Club Episode 92 to explore the role of phosphatidylcholine in lipid metabolism, methylation, and mitochondrial integrity during aging. He also highlights how estrogen loss may impact this pathway, especially in pre- and post-menopausal women.
Aging-Associated Decline of Phosphatidylcholine Synthesis is a Malleable Trigger of Natural Mitochondrial Aging
Dr. Seeds explores how age-related decline in phosphatidylcholine synthesis may contribute to mitochondrial aging and why that matters in Cellular Medicine. This discussion connects membrane integrity, mitochondrial function, methylation, and metabolic resilience, while highlighting how this pathway may be more modifiable than we once thought.
1. Managing shingles outbreaks in GLP-1 patient through peptides (0:40)
2. Peptide strategies in suspected ALS (15:56)
3. Improving durability in dementia treatment (25:08)
In this bonus episode from the MM15 Virtual Summit, Dr. Seeds addresses an important question around the use of GLP-1s for metabolic balancing in patients who do not need to lose weight. He shares his perspective on what may be considered microdosing, along with the clinical thought process he uses when determining appropriate dosing in these more nuanced cases.
Additional questions from the MM15 Virtual Summit can be found in our accompanying article here: [insert article link]
Access the full MM15 Course here: Mastermind 15 on Aesthetics
The Limits of Alternative Peptide Delivery
Dr. Seeds reviews oral, sublingual, and transdermal peptide delivery, and explains why subcutaneous injection remains the gold standard for most peptides. (Question Link)
A Deeper Look at the RAAS System
Dr. Seeds uses this Rabbit Holes episode to build on Journal Club Episode 87, revisiting the renin-angiotensin-aldosterone system and its broader role in cellular signaling. The discussion focuses on receptor balance, local tissue effects, and the mechanisms linking RAS disruption to inflammation, fibrosis, and mitochondrial stress.(Article Link)
The Renin–Angiotensin–Aldosterone System (RAAS): Beyond Cardiovascular Regulation
Dr. Seeds unpacks how RAS receptor balance drives inflammation, fibrosis, mitochondrial dysfunction, and tissue remodeling, far beyond its classical role in blood pressure regulation. (Article Link)
1. SSRI tapering resistance, anxiety during weaning (0:40)
2. Progressive multifocal dystonia (13:27)
3. Complex type 2 diabetes case in a lean, athletic patient (28:32)
Peptide Pharmacokinetics
Dissecting Protocols, Dr. Seeds breaks down the reasoning behind SubQ vs. IM peptide administration. From pharmacokinetic considerations to the growing misuse of combining peptides with oil-based medications in the same syringe, this discussion helps clarify proper application and safety considerations.
The Cellular Impact of UVA vs. UVB Light (Part 2)
Dr. Seeds continues this Rabbit Hole on UVA vs. UVB light in Part 2, covering oxidative stress, skin aging, vitamin D synthesis, and the risks of tanning beds. A helpful look at why not all UV exposure works the same, why that distinction matters, and how it shapes both skin health and cellular function
Catch Part 1 (Rabbit Holes – Ep. 081) HERE
Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients
Dr. Seeds discusses this article on low dose minoxidil for hair loss and shares why a lower, slower dosing approach may lead to better outcomes. He also reviews key safety considerations, side effects, and practical dosing insights for both men and women. (Article Link)
1. Idiopathic pulmonary fibrosis in patient already receiving immunosuppressive therapy (1:01)
2. Peptide considerations for a 14-year-old diagnosed with “internal preoccupation” (28:44)
3. Patient with hypermobility, mitochondrial dysfunction, and mast cell activation after COVID (39:48)
The Cellular Impact of UVA vs. UVB Light (Part 1)
In this Rabbit Holes episode, Dr. Seeds explains the mechanistic differences between UVA and UVB light, highlighting how each spectrum uniquely contributes to photoaging, oxidative stress, DNA damage, and skin cancer risk. He also outlines cellular strategies to support antioxidant defenses, mitochondrial function, and DNA repair in response to chronic light exposure.
Want to learn more? Check out Mastermind 15 on Aesthetics!
BPC-157 vs. TB-500: Evaluating Unexpected Joint Symptoms
Dr. Seeds reviews a case of swelling, joint stiffness, and tingling that appeared after stacking BPC-157 with TB-500, using it as a framework for thinking through peptide reactions, sourcing, and causality. (Question Link)
Sleep Through the Lens of Cellular Medicine
In this episode of Rabbit Holes, Dr. Seeds discusses how light exposure, thermal regulation, and autonomic signaling influence sleep, circadian rhythm, and mitochondrial health through the lens of cellular medicine.
The Effects of AG1® Supplementation on the Gut Microbiome of Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Dr. Seeds reviews a randomized controlled study on AG1 and its potential impact on the gut microbiome. The research shows short-term probiotic survival and safety but no significant changes in microbiome diversity or systemic metabolic effects. Dr. Seeds discusses what the study supports, what it doesn’t, and why careful interpretation of research matters in clinical practice. (Article Link)
1. Post-chemotherapy fatigue and neuropathy in a colorectal cancer survivor peptide safety and immune support (0:48)
2. Severe food reactivity with mast cell involvement and redox imbalance (07:50)
3. Severe pediatric JIA with MIS-C and persistent hyperinflammation (23:34)
Rethinking OCD Through a Cellular Medicine Lens
Dr. Seeds explores OCD as a circuitry and maladaptive learning issue, discussing neurotransmitter balance, oxidative stress, and mitochondrial function while highlighting a non-SSRI approach that pairs cellular support with ERP to promote lasting change. Question Link
The Truth About Ketone Esters
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Dr. Seeds reviews a newly published peer-reviewed article, coauthored with his colleagues, examining how cellular medicine and peptides support orthopedic wound healing through regenerative signaling and cellular repair mechanisms. (Article Link)
1. Peptides for fertility (0:40)
2. NAD⁺ and GHK-Cu dosing considerations (10:00)
3. Peptide safety for patient with a stroke and chronic migraines (12:33)
LADA Protocol
Dr. Seeds answers a clinician question on implementing a LADA-focused approach, clarifying peptide sequencing, biomarker monitoring, and expectations around immune modulation, metabolic support, and beta-cell preservation within a cellular medicine framework.
The Cellular Side of Spermidine
Polyamines Sustain Epithelial Regeneration in Aged Intestines by Modulating Protein Homeostasis
Dr. Seeds reviews new research on how polyamines support intestinal regeneration in aging tissue by improving protein homeostasis and translational efficiency. He explores the clinical relevance of spermidine, dietary interventions, and polyamine pathway modulation in protecting gut resilience after injury. (Article Link)
1. Peptides for frozen shoulder (0:39)
2. Safety alongside PPI therapy in an active duodenal ulcer (09:27)
3.Protocols for a complex patient with post MRI tinnitus and hyperacusis (21:03)
Polycystic Kidney Disease & Mitochondrial Support
Dr. Seeds explores how calcium dysregulation and mitochondrial dysfunction drive the progression of polycystic kidney disease. Learn how GLP-1s, AMPK activation, and mitochondrial peptides like MOTS-c and SS-31 may support energy balance and cellular repair in PKD.
Kisspeptin Beyond IVF: Promise, Limits, and What the Science Says
How Exercise Lactate Drives Brain BDNF
IV Lactate, BDNF and Exercise
Dr. Seeds breaks down a new study on IV lactate and pro BDNF, clarifying what it means for brain health and cellular medicine. (Article Link)
Pinealon and Sleep
High-Intensity Interval Training & Brain Plasticity
Dr. Seeds reviews a systematic study linking HIIT to CREB activation—fueling neuroplasticity, memory, and resilience. Learn how the right training intensity activates BDNF, improves cognition, and may serve as a non-pharmacologic therapy for neurodegenerative diseases. (Article Link)
Brain Energy Metabolism: Rest vs. Exercise
Dr. Seeds explains how the brain uses fuel differently at rest and during exercise—and why lactate, glucose, and mitochondrial signaling matter. From Zone 2 to HIIT, discover how different workouts boost neuroplasticity, cognitive performance, and brain resilience.
Are GLP-1s Causing Muscle Loss? Here’s What to Do.
How Vitamin B3 May Help Reduce Skin Cancer Risk
Dr. Seeds reviews a large-scale clinical study on nicotinamide (vitamin B3) and its ability to reduce skin cancer risk. He explains how nicotinamide supports DNA repair and immune balance in keratinocytes following UV exposure—showing up to a 50% reduction in secondary skin cancers. A fascinating look at how cellular repair pathways, NAD metabolism, and targeted supplementation intersect in the prevention of UV-induced disease. (Article Link)
Sodium, Glucose Pathways, and Liver Health
October 2025 Office Hours
1. Metabolic, hormonal, and psychological recovery in complex perimenopausal case [0:43]
2. Measure peptide outcomes beyond symptoms and track mitochondrial flexibility [15:02]
3. Strategies for treating recurrent, therapy-resistant C. diff colitis [26:20]
4. Mitochondrial case centered on enhancing muscle strength and respiratory resilience [30:42]
GLP-1 Not Working Like It Used To? Here’s What to Do Next.
Semaglutide Slows Epigenetic Aging in People with HIV-associated 3 lipohypertrophy: Evidence from a Randomized Controlled Trial
Dr. Seeds reviews a new study on GLP-1 receptor agonists and their potential to slow biological aging in HIV patients, measured through DNA methylation clocks. He highlights both the promising findings on inflammation, brain, and heart aging. (Article Link)
NAC vs. IV Glutathione
Is IV Glutathione Overrated?
Dr. Seeds clears up the confusion between IV glutathione and oral N-acetylcysteine (NAC). What’s more effective for long-term glutathione support? He breaks down the science, including why IV glutathione may not work the way you think—and when it can be useful. From biochemical breakdowns to clinical use cases, this episode is packed with clarity on one of the most misunderstood antioxidant strategies.
Fasting, Food & Peptides
In this episode, Dr. Seeds answers a common question: Do peptides need to be taken on an empty stomach? He explains why growth hormone secretagogues like CJC/Ipamorelin are best taken fasted, why oral BPC and KPV stand out, and how carbs, fats, and insulin impact growth hormone pulses. With practical guidance on timing and a clear look at the science, this episode offers members the clarity they need to optimize peptide use.
Can one year of heavy lifting change the course of aging?
Dr. Seeds unpacks the groundbreaking LISA Study, which tracked older adults over four years after just one year of resistance training. The results? Remarkable strength preservation, visceral fat control, and evidence of long-term neuromuscular adaptation—especially in women.
Explore why strength—not just muscle mass—matters for health span, and how these findings reinforce the cellular medicine approach to aging, recovery, and metabolic resilience. (Article Link)
Resistance is Vital: Training for Healthspan
Dr. Seeds unpacks why resistance training is one of the most effective tools for preserving muscle, improving mitochondrial function, and extending health span—especially in older adults. He connects key cellular pathways like AMPK, mTOR, and PGC-1α to real-world outcomes like strength retention, metabolic flexibility, and reduced inflammation. With new long-term data from the LESA study, this episode offers essential insight for anyone focused on aging well through the lens of cellular medicine.
- Exploring metformin for muscle health vs impared mitochondrial function and blunt adaptation to exercise? [01:15]
- Chronic Bartonella symptoms using a cellular approach before antibiotics? [17:04]
- OS-1 peptide for hair growth? [36:21]
Incorporating MOTS-c with NAD
Dr. Seeds breaks down the molecular strategies behind improving metabolic flexibility using MOTS-c and a deeper understanding of NAD salvage pathways. Learn why substrate switching is key for energy efficiency, and how precise interventions—like small molecule NNMT inhibitors—can reshape redox balance and mitochondrial resilience. Whether you’re treating aging, fatigue, insulin resistance, or mitochondrial dysfunction, this is essential education for anyone interested in precision cellular medicine.
Methylene Blue and Misconceptions
This month, Dr. Seeds explores a recent study examining methylene blue’s acute effects on the brain in healthy individuals. He breaks down the cellular mechanisms at play—including oxidative phosphorylation, nitric oxide inhibition, and dose-dependent effects on brain metabolism—and explains why this popular “longevity” compound may be doing more harm than good outside of clinical contexts. (Article Link)
The Telomere Trap
This month on Rabbit Holes, Dr. Seeds challenges one of the most widely misunderstood topics in the longevity space: telomeres.
Are longer telomeres really the key to living longer? Or is the real driver of health span hidden in mitochondrial resilience, redox balance, and functional cell integrity?
In this eye-opening episode, Dr. Seeds explores the difference between replicative vs. functional senescence, revealing why the telomere hype may be missing the bigger picture in post-mitotic cells like neurons, heart, and skeletal muscle.
- Should bodybuilders use collagen? Research-backed guidance on its role in training and tissue repair. [0:38]
- Mitochondrial myopathy, Hashimoto’s, and asthma in a 64 y/o female—how to improve strength and respiratory resilience. [11:23]
- Post-liver lobectomy with PCOS and poor sleep; peptide suggestions. [22:32]
Beyond Energy: How Mitochondria Adapt to Life
This month on Rabbit Holes, Dr. Seeds challenges the reductionist view of mitochondria as “the powerhouse of the cell.” He takes us deep into how mitochondria regulate energy, metabolism, morphology, and redox — and why their ability to adapt is at the core of preventing dysfunction, disease, and decline.
Whether you’re working with clients, patients, or protocols, this episode will give you the context needed to understand cellular adaptation and its real-life clinical relevance.
Is TA1 Underdosed in Sepsis?
In this episode, Dr. Seeds breaks down a recent clinical trial on Thymosin Alpha-1 in sepsis, weighing its results against real-world application. Learn why dosing, biomarkers, and peptide combinations like TB4 matter more than ever.
Can Walnuts Boost Brain Power?
Dr. Seeds reviews a study on how a walnut-rich breakfast affects cognition and mood in healthy adults.
The episode explores glucose metabolism, brain performance, and the potential of food as a clinical tool. (Article Link)
Omega-3 vs Omega-6: What Really Matters
In this episode of Rabbit Holes, Dr. Seeds unpacks the delicate balance between pro- and anti-inflammatory fats, breaking down how omega-3 and omega-6 fatty acids impact your health—from immune response to chronic inflammation.
From Concept to Clinical Strategy
In this episode, Dr. Seeds evaluates a detailed, phase-based plan submitted by an SSRP member—highlighting where to start, how to sequence, and why clarity matters in cellular-focused protocols.
Insightful, practical, and packed with takeaways for your own clinical journey.
Circadian Clocks & Cellular Consequences
In this Journal Club episode, Dr. Seeds explores how early school schedules disrupt natural rhythms—and what that means for mitochondrial health, gene expression, and recovery.
A must-watch for understanding why time is a molecule in cellular medicine. (Article Link)
Methylation, Muscle & the Epigenome
Explore how epigenetic shifts—like DNA methylation and histone acetylation—link exercise to improved gene expression, redox balance, and cellular resilience. A foundational discussion in the cellular medicine model.
The Potential Influence of Melatonin on Mitochondrial Quality Control: A Review
This Journal Club session dives into the cellular strategies that boost metabolic flexibility, stress adaptation, and energy efficiency. A must-watch for anyone wanting to understand how the cell stays optimized under pressure. (Article Link)