9 Replies

• Author
  Posts
• June 7, 2021 at 2:49 pm #29767
  Carrie Hardy

  Member

  SSRP Certified

  Hello Everyone!  I have a patient that has been doing her own research into peptides and she had asked me about Humanin for neurological health.  I haven’t heard of this peptide in the past but there appears to be some research into this peptide (apparently mitochondrial derived) that is supportive for CV health.  Does anyone have any experience with this peptide and of course any sourcing recommendations would be welcomed as well.

  Thanks in advance

  Carrie

  June 7, 2021 at 2:57 pm #29768
  Robb Bird

  Participant

  SSRP Certified

  I am interested in this as well…..and dosing info.

  June 7, 2021 at 3:29 pm #29769
  Robin Rose

  Member

  SSRP Certified

  I recall Dr Seeds remarking this was out of the ballpark expensive. Any update on that?

  June 8, 2021 at 9:53 pm #29770
  Abid Husain

  Participant

  SSRP Certified

  Humanin was available for a limited period of time but it wasnt a reliable pharmacy.  They no longer provide it and are not a trusted source.  No other trusted compounding pharmacy has picked it up.  The only place to get it now would be from labs that are for “research only” purposes.  The purity can’t be trusted and wouldn’t be recommended.

  That being said, what CV benefits are your patient looking for?  There are plenty in the current toolbox to treat most CV conditions without going to a rare and expensive peptide.

  Abid

  June 15, 2021 at 10:37 am #29771
  Carrie Hardy

  Member

  SSRP Certified

  Hello Abid

  Thank you for taking the time to respond.  This patient is in her late 50s and she has a history of breast cancer.  She has developed significantly reduced ejection fractions (suspected from her chemotherapy).  She is in shape and her cardiologist has placed her on blood pressure medications but she isn’t tolerating this well and she is having difficulties continuing with her exercise (was a runner but is now just trying to swim).  They feel that she will recover but it will take several months and she can’t continue with her chemotherapy

  Thanks again.
  Carrie

  June 15, 2021 at 1:03 pm #29772
  Abid Husain

  Participant

  SSRP Certified

  How long ago was her chemo exposure?  Was is Anthracyclin based chemo?

  The cardiotoxicity is thought to be ROS mediated with significant reductions in  glutathione and mitochondrial dysfunction.  Supplemental Glutathione would be a good place to start.  I would start her on ketone esters 2.5ml TID.  The failing heart is more dependent on ketones as a fuel source and this will help provide the needed fuel to help it potentially regain improved function.  As well, the immune / inflammasome regulation will be helpful to reduce the ROS mediated inflammation.

  Introduction of an SGLT2 inbibitor would be a reasonable option as there is good data for heart failure.

  As far as peptides, I would start with BPC-157 500mcg SQ BID,  TA-1 1mg SQ QD,  CJC/Ipamorelin 100mcg/100mcg 5/7 SQ nights for the first month.  then reduce the TA-1 to 500mcg QD.    Depending on budget MOTS-c may be able to help imnprove mitochondrial funtion.

  Here is an article to help get some backround infomation on this condition.

  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318862/

  Abid

  June 15, 2021 at 9:15 pm #29774
  Elizabeth Yurth

  Member

  SSRP Certified

  @dr-carriehardygmail-com

  Spermidine Promotes Cardioprotective Autophagy

  Dan Tong

   and 

  Joseph A. Hill

  Originally published14 Apr 2017https://doi.org/10.1161/CIRCRESAHA.117.310603Circulation Research. 2017;120:1229–1231

  Cardioprotection and lifespan extension by the natural polyamine spermidine

  Eisenberg et al

  Nat Med. 2016;22:1428–1438

  A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses aging-associated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.¹

  If can get SS31-it would be amazing !

  And @drhusaininterlinkedmd-com..wouldn’t adding telmisartan be useful?

  Betsy

  June 17, 2021 at 1:23 pm #29775
  Abid Husain

  Participant

  SSRP Certified

  Telmasartan may be helpful but BP tolerance may be an issue.  It has been shown to stimulate PPAR aphla and gamma for lipid peroxidation,  prevents vascular smooth muscle cell and cardiac fibroblast hypertrophy, and inhibits platelet derived growth factor.  There also seems to be antioxidant properties that reduce oxidative burden and potentialy reduce atherosclerosis.

  This commentary is a great and brief summary.

  Benndorf, Ralf A; Böger, Rainer H Pleiotropic effects of telmisartan: still more to come?, Journal of Hypertension: May 2008 – Volume 26 – Issue 5 – p 854-856
  doi: 10.1097/HJH.0b013e3282f76481

  June 18, 2021 at 11:05 am #29776
  Carrie Hardy

  Member

  SSRP Certified

  Betsy and Abid

  Thank you so much for your input on this case.   The last dose of the chemotherapeutic was in Jan of this year.  I was trying to quickly find what she was taking but I can’t readily locate it.  Your help is greatly appreciated.

  Carrie

  January 31, 2022 at 11:02 am #29777
  Kristelle Reyes

  Member

  SSRP Staff

  Claim your CME here: https://earnc.me/GpE2rH

• Author
  Posts