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• August 5, 2022 at 6:59 am #31857
  Patricia Salvitti

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  SSRP Certified

  It is known that:

  Hcrt-1 and Hcrt-2 peptides are undetectable in brain tissue of narcoleptic patients, and that narcoleptic patients exhibit an 85–100% loss of Hcrt neurons compared to control patients

  https://www.sciencedirect.com/science/article/pii/S2590098620300579

  Rather than a targeted peptide for narcolepsy or excessive daytime sleepiness, anybody have experience with peptides that support the hypothalamus in general and those conditions?

   

  August 8, 2022 at 10:34 am #31859
  Geoff Jones

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  SSRP Certified

  I have narcolepsy.  Have trialed many peptides such as DSIP, epithalon, thymulin as well as using CJC/Ipa, TA1, BPC.  The things that seem to make the biggest difference for me include Xyrem, and Prodrome Neuro in the AM and Prodrome Glia at bedtime (I use 4 caps of each).  I find narcolepsy patients to be quite variable in what they respond to.  Overall, the best results I’ve seen are combining Xyrem and Armodafinil.

  August 8, 2022 at 4:06 pm #31860
  Patricia Salvitti

  Member

  SSRP Certified

  Appreciate you sharing your experience.

  I’m currently taking Prodrome Neuro and Glia which have helped, and now have a script for a sleep study and MSLT.  I’ve put off doing the studies for many years because the medical solutions appeared to be just a bandaid.

  Will be looking into Xyrem and Armodafinil.  Would be nice to stay awake, instead of falling asleep anytime I sit for any length of time!

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