Hi Maggie,
Typical LL-37 dosing is 100-200mcg BID for 4-6 weeks. You can start low and then titrate up as long as the patient is tolerating well. In our practice, the dosing we use with our patients is 100mcg-200mcg BID for 4-6 weeks, so the daily dose is 200mcg-400mcg. We don’t typically go any longer than 6 weeks with the patient.
LL-37 is a great peptide but remember for your patients who have underlying autoimmune disorders, you need to be cautious. It activates your innate immunity, so it can aggravate certain conditions like active psoriasis/PsA, systemic lupus (SLE-spectrum), vasculitis and prothrombotic states due to NET-linked risk. It also amplifies type 1 IFN signaling, enhancing antigen presentation which can then skew Th1 responses potentially worsening autoimmune conditions and drive beta-cell injury in Type 1 DM patients. If autoimmune disease is present, just start low, 100mcg/day, and titrate up slowly but only continue to increase if tolerating well.
For more insight, here’s a detailed article discussing LL-37’s role in immune regulation and disease outcomes:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7246396/
Hopefully this information was helpful.
Thank you
@justinbiofuse-net
.