Air Quality, Oxidation and Redox

[Anthony Castore]

Greetings, fellow SSRP members and faculty.  With the air quality issues that have been prevalent as a result of the Canadian wildfires, a number of my clients (and I) have been experiencing some ills (nausea, headaches, and fatigue mostly)

Some studies suggest that certain compounds may mitigate the harmful effects of exposure to wildfire smoke. For example, a study found that sulforaphane in cruciferous vegetables can protect against oxidative stress and inflammation caused by wildfire smoke exposure[1]. Another study found that resveratrol in grapes and red wine can reduce inflammation and oxidative stress in the lungs caused by wildfire smoke exposure[2]. 

I wondered if something like 5amino-1mq could also be helpful for its effect on the salvage pathway or MOTSc/SS31 for their effects on mitochondrial oxidative stress.

There is limited research on the effects of IV vitamin C specifically on wildfire smoke inhalation. However, some sources suggest that vitamin C may potentially mitigate the harmful effects of smoke inhalation. 

– According to[1], receiving an IV therapy rich in vitamin C and other key vitamins and minerals can help mitigate the effects of wildfire smoke inhalation. 

– [2] suggests that smoke causes oxidative damage and vitamin C is one of the best nutrients to help offset inflammation in the body. 

– Similarly, [3] notes that smoke causes inflammation via oxidative damage, so antioxidants like vitamin C can be helpful during this time. 

– However, [4] points out that no studies investigating vitamin C administration’s effects on isolated smoke inhalation injury. 

Sources

[1] Impact of California Wildfires on Our Families Health https://mobileivmedics.com/protect-health-california-wildfires/

[2] Tips to Support Your Lungs from Wildfire Smoke https://www.onepeakmedical.com/10-easy-tips-to-support-your-lungs-from-wildfire-smoke/

[3] Stay Healthy During Wildfires https://www.360-md.com/blog/stay-healthy-during-wildfires

[4] Pathophysiology, management and treatment of smoke … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722076/

I work in the strength coaching world, so from my perspective, I have taken the initiative to reduce the training volume for clients and moved them into more neural hypertrophy workouts (longer rest periods and heavier weights, lowers reps). For now, I encourage my clients to stay away from running or cycling in favor of indoor swimming for aerobic work. It has the added benefit of deloading the joints from the heavier weights in the neural phase we are currently working on as well. My thinking was this allows the maintenance of an aerobic base but, minimizes toxin exposure and excessive oxidative stress.

I would love to hear thoughts from others and try to get a better understanding of the specific pathways’ affected so I can make intelligent choices for clients and provide the best health solutions. These forums have been a goldmine of wisdom, and I appreciate so many great minds willing to help.  Any additional thoughts or input would be amazing!! Thank you in advance for your thoughts and for taking the time to respond.

Sources

[1] How wildfire smoke can threaten human health, even when … https://www.pbs.org/newshour/science/how-wildfire-smoke-can-threaten-human-health-even-when-the-fire-is-hundreds-of-miles-away

[2] Wildfire Smoke Exposure during Pregnancy: A Review of … https://www.mdpi.com/1660-4601/19/21/13727

[Anthony Castore]

There were some bioregulator peptides I found but, I don’t have any direct experience with them but. It would be greatly appreciated if anyone does and would like to comment.

Several bio-regulator peptides may affect the lungs. Here are some examples:

1. **Bronchogen**: Bronchogen is a bioregulatory peptide with tissue-specific effects in the lungs. Research in rat models shows that Bronchogen can decrease inflammation and reestablish healthy lung tissue states by affecting several DNA transcription pathways.

2. **EPI PL**: EPI PL is a peptide bioregulator for the lungs and bronchial mucosa. It helps improve oxygen uptake, acts as a natural antioxidant, and is a lung tissue regenerator and bioregulator of post-infection reactions.

3. **Taxorest**: Taxorest is a lung peptide bioregulator that contains a peptide complex specific to the lungs. It is recommended for chronic bronchitis, bronchial asthma, and pulmonary disease. Taxorest appears to improve the effectiveness of standard therapy in the setting of chronic bronchitis with an asthmatic component and has stress-protective effects.

4. **Chonluten**: Chonluten is a short peptide bioregulator of gene expression. Research has shown it to be most active in lung tissue with secondary levels in other areas. It regulates inflammation-related genes and has been shown to be effective for treating bronchopulmonary pathology.

5. Pentosan polysulfate (PPS) is a medication that has been shown to have anti-inflammatory effects and to reduce oxidative stress in various studies. Here are some of the effects of PPS on inflammation and oxidative stress in the lungs:

– **Inhibition of inflammation**: PPS has been shown to inhibit inflammation in various studies[1][2][3][4]. In a study on high glucose-treated HK-2 cells, PPS was found to ameliorate apoptosis and inflammation by suppressing activation of the p38 MAPK pathway[3]. In another study on a mouse model of influenza virus A/PR8/34-induced pulmonary inflammation, PPS was found to have anti-inflammatory actions[2].

– **Reduction of oxidative stress**: PPS has been shown to reduce oxidative stress in various studies[1][5]. In a study on rats with ischemia/reperfusion injury, PPS improved renal function and fibrosis, possibly by reducing oxidative stress[4]. In another study, PPS was found to afford pleiotropic protection to kallistatin, a kallikrein inhibitor that has pleiotropic effects on angiogenesis, oxidative stress, inflammation, and apoptosis[5].

Sources

[1] Inhibition of inflammation by pentosan polysulfate impedes the … https://www.semanticscholar.org/paper/Inhibition-of-inflammation-by-pentosan-polysulfate-Wu-Guan/a964b11934d3ae116c475d58e226aa2d99931d99

[2] Anti-inflammatory actions of Pentosan polysulfate sodium … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947849/

[3] Pentosan polysulfate ameliorates apoptosis and … https://www.spandidos-publications.com/10.3892/ijmm.2017.3290

[4] Pentosan polysulfate ameliorates fibrosis and inflammation … https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-022-02732-8

[5] Pentosan Polysulfate Affords Pleotropic Protection to … https://www.mdpi.com/1424-8247/16/3/437

 

[Kristelle Reyes]

Hello @drhusaininterlinkedmd-com, @byurthgmail-com, and @andkeller2gmail-com we would love to have your insights here. Thank you! 🙂

[Christina Campbell]

I would love to hear your input here as well SSRP docs!  I am trialing Bronchogen SQ with a patient currently who has chronic long term immune mediated pulmonary issues. We are microdosing because she states she feels “really weird” with any dose higher than 250 mcg.  I have seen dosing recommendations from 500mcg daily to 2 mg doses SQ daily for 10 days at a time so this is a huge range.

I am looking at Taxorest for an 18 yo with chronic asthma and recurrent pneumonia/chronic bronchitis (the diagnoses codes have a wide range in his chart) but he has been on antibiotics for the better part of 2 years before finding me.  So I am doing all the Fx med stuff but he is an athlete who tanked out at his State Championship meet because he “couldn’t breathe well enough to perform at his best” .  He is not up for needles so also looking at oral T4 Frag and Thymogen alpha 1 oral both from Integrative peptides.

*I would love any input on lung restoration and these particular peptides mentioned by @Anthony Castore above.

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