ARA-290

[Lisa Waterman]

Can ARA – 290 be used for chronic knee pain related to patellofemoral pain syndrome, what dose and order of treatment… Patient is taking BPC already but not much improvement.  Is there a place to start Thymulin to reduce immune first then add ARA and CJC??

[Kristelle Reyes]

Hello @byurthgmail-com, @dr-siobhannewmangmail-com and @drhusaininterlinkedmd-com, we would love to have your insights here. Thank you! 🙂

[Elizabeth Yurth]

ARA would not be my go.  It may have slight benefits for pain because of its effect on NMDA receptors.  But you would do best here using pentosan polysulfate!!

Dr Yurth

[Mitchell Fleisher, M.D., D.Ht., D.A.B.F.M.]

I agree with Betsy.  PPS 0.25-0.5 ml SQ adjacent to the joint(s) TIW/QIW can be very effective.

In addition, I would use KPV 500 mcg po BID, and apply KPV Lipodernal Cream to the knees BID/TID.

Also giving glucosamine sulfate, methylsulfonylmethane (MSM) and Astaxanthol supplementation daily will be helpful long term.

DrM

[Lisa Waterman]

Can Pentosan be used long term, and subcutaneous is fine??  ( she has been on celebrex 200 bid for 12 years… )

[Sarah Kurts]

Oh, I didn’t realize that PPS was to be injected SQ adjacent to the affected joint(s). I have just started on myself and have been injecting twice weekly SQ in abdomen, hoping it would improve multiple joints. Is this technique not going to be helpful for me? (My affected joints involve several fingers and one great toe).

 

[Mitchell Fleisher, M.D., D.Ht., D.A.B.F.M.]

There will be some benefit with the abdominal SQ injections, but it works better closer to the arthritic joints.

Stop the Celebrex, and continue BPC-157 500 mcg po BID to repair the stomach.

Start the recommended supplements above.

 

[Abid Husain]

I’d consider BPC SQ instead of PO and scale up the doses.  You could consider using 500mcg TID SQ or 1000m mcg BID.  I see better response to SQ as compared to oral dosing with joint inflammation.

[Sarah Kurts]

Abid, are you referring to SQ BPC dosing at the location of the affected joints, in conjunction with SQ dosing of PPS at the same locations?

 

 

[Abid Husain]

Yes, if there is a specific joint of concern.

[Lisa Waterman]

How long can BPC at high doses be used… life long or drop down for maintenance.  She feels better at higher dose of BPC but have only gone 300 bid.  Pentosan sSQ or IM, feel like at the cert course it was stated works better with deeper injection???

[Abid Husain]

There is no toxic dose to BPC.  You could condieveably titrate up to optimal symptom relief.  Once you reach that, maintain it for 2-3 months and then attempt to titrate down for symptom maintenance.   When I refer to high doses, I am advising going up in 500mcg increments at a time.  The minimum I use for joint inflammation is to start with 500mcg BID.

The treatment of joint relief can be a slow moving process so advise them that patience and multiple agents will be needed.

[Abid Husain]

And no known time limit.

[Lisa Waterman]

Thank you so much!! Appreciate it!!!

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