Dosing larazotide… for a 2 year old I would usually do 1/2 capsule (of 500mcg) daily.
(When you look at the research of what they used on kids in the hospital with MIS-c .. the dosing was 10mcg/Kg QID for 21 days. So if the kid was lets say 20 pounds, that would be 90mcg X 4daily. So my 250mcg is fine.)
And most importantly, usually VERY effective and fast at that dose.
As for how long? It depends on if you have stopped the trigger.
If the trigger is over (food insult, viral GI insult, etc) then certainly a week to 2 weeks is usually fine in my kids.
But if the insult is ongoing, or you do not know what it is fully (like in this case where it is likely something that will need more “clean up” of the gut)…. then the larazotide would need to be longer. In cases like this… I just trial off, and the kid’s symptoms will tell you if they need it still.
As for BPC, as I have mentioned… since using larazotide in these cases, I haven’t also usually needed BPC. So, as far as how long to use it, I guess I would say that it doesn’t seem to work as fast in my experience so I would maybe try it for a month and then try off to see if they “missed it”.
As for the plane flight triggering…
Hummm, in my CIRS and chronic TBD patients flying is VERY hard on them due to the dropped air pressure. While this mild dip likely won’t bother anyone with good vascular flow in the smaller vessels, it absolutely does in these patients. (I suspect this is about Henry’s Law saying that you can get more gas into plasma under higher pressures. Therefore they get lots of fatigue and brain fog with flying due to relative dip in perfusion, etc ). But this wouldn’t explain things in your patient.
So I would “sleuth” a bit more. Do they give her a special treat for keeping her happy while flying? Did they give her something for discomfort that they do not usually give her? Eat processed food when they do not normally, etc. I suspect that they are missing the link and that it is something that the child puts in their mouth.
🙂
.