Butyrate

[Eric Fete]

I would love any input on the downsides of butyrate supplementation.  I am all for using food to push the microbiome to  make enough but s/t we have to give butyrate for optimal effect.  The question is how to monitor and how much?  I have spoken with a few in the nutrition space who mentioned this not being a good idea suggesting that actual supplementation with butyrate could have adverse consequences such as promoting cancer and other effects.

Anyone aware of any data on risks of supplementation?

Eric

[Kris Wusterhausen]

Eric, I am not aware of any data showing risks of supplementation. Actually, the studies show that sodium butyrate has anti-cancer effects. Of course, I feel that the healthier the gut is overall the better a patient will do. I have found that I have to start with two butyrate’s a day and work up to 2 twice to three times a day depending on gut tolerability.  I am including below an excerpt from a 2020 study.

Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1

Wenqi Wang,^#1,2 Daoquan Fang,^#3 Hao Zhang,¹ Jiao Xue,¹ Drugyel Wangchuk,⁴ Jimei Du,¹ and Lei Jiang³

Author information Article notes Copyright and License information Disclaimer

This article has been cited by other articles in PMC.

Background

Sodium butyrate (NaB) is a short-chain fatty acid which is produced by bacterial fermentation of nondigestible dietary fiber and has been reported to exert anti-tumor effects in many tumors including colorectal cancer (CRC).

Hope this helps

Kris Wusterhausen, DO

[Kristelle Reyes]

@ejfete71gmail-com-2

Always great to have your input, Dr. Wusterhausen. Thank you!

🙂

[Eric Fete]

Thanks!

Eric

[Kristelle Reyes]

Hi @drhusaininterlinkedmd-com and @byurthgmail-com, would love to have your opinion here as well!

Thank you!

[Abid Husain]

Hello Eric,  I agree with Kris.  I have not read or heard of any cancer concerns with butyrate.  Everything I have read shows cancer prevention and even some therapeutic effects in colorectal cancer.  The full mechanisms are not fully understood but the benefits are there.

I use a similar protocol as Kris and add BPC-157 , VIP, oral IgG depending on how much help their gut requires..

These are two articles that review the specifics of those effects of Butyrate.

https://www.researchgate.net/profile/Pedro-Goncalves-40/publication/258100941_Butyrate_and_Colorectal_Cancer_The_Role_of_Butyrate_Transport/links/0deec529c76f95e3ec000000/Butyrate-and-Colorectal-Cancer-The-Role-of-Butyrate-Transport.pdf

https://www.researchgate.net/profile/Elizabeth-Williams-7/publication/10766288_Anti-cancer_effects_of_butyrate_Use_of_micro-array_technology_to_investigate_mechanisms/links/541c30ce0cf2218008c4f7bc/Anti-cancer-effects-of-butyrate-Use-of-micro-array-technology-to-investigate-mechanisms.pdf

Hope this helps!

Abid

[Kristelle Reyes]

Claim your CME here: https://earnc.me/KeaXcH

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