Cerebral Palsy and Peptide treatments

[Aaron Hartman]

I have a 15 year old girl with a history of CP, crystal meth drug exposure in utero, Grade 2 intrauterine hemorrhage,  who at 2 years of age had severe neurological issues. She couldn’t sit, talk or see. Since then I’ve done multiple therapies with her and at this time she is able to walk with forearm crutches, loves to joke and talk and just started writing several weeks ago after a treatment series with HBOT. We have also done POnS therapy with her for over a year, NMS, IV lipids, SNP testing and treatment, et al. At this stage I feel the next level of therapy to address is peptide therapy. Hence my question.

My question is, what would be the ideal starting peptide protocol for a 15 year old with the above neurological issues. She gets routine nutritional testing, is lipid optimized, gut optimized, and gets 3-4 hours of PT daily. I like to joke that she would be an Olympian, is she didn’t have CP. The protocol would need to maximze on the extend of daily PT/OT she gets as well as pool therapy. Any thoughts from anyone on was to boost what we are doing with peptides would be appreciated.

 

Thanks

[Mitchell Fleisher, M.D., D.Ht., D.A.B.F.M.]

Aaron,

It would be reasonable to initiate peptide therapy with TA1 to help mitigate the chronic neuro-inflammation underlying the cerebral palsy; 0.25 to 0.5 ml SQ BID for 12 weeks or longer.  Also, consider referral for constitutional homeopathic medical consultation.

Other excellent, adjunctive nutritional support for CP is plasmalogen therapy, specifically ProdromeNeuro 1-2 ml po BID and ProdromeGlia 1-2 ml qday; learn more about the phospholipid plasmalogens at  https://prodrome.com/practitioner-registration/?ref=130

Best, Dr. Fleisher

[William Seeds, MD]

Thank you Dr. Fleisher! Always great to have your input =)

@hartmanangmail-com

[Kristelle Reyes]

Hello doctors  @drhusaininterlinkedmd-com  @tl2bactivegmail-com  @drkriswyahoo-com, would love to have your inputs here too. Thank you! ?

[Abid Husain]

I would also consider specific nootroptic peptides.  P21 is the best current neuropeptide that will stimulate neuroregneration and has neurotropic properties.  The art will be in the dose.  The current dosing recommendations are likely low.  It comes in a nasal spray and available via PureRx.  I’d recommend 2 sprays to each nostril daily and scale up to 4 sprays to each nostril over a month if tolerated.  I’d also add Dihexa for it’s BDNF properties.  Again, the dosing is the art.  It comes in 20 mg caps but it seems that is too low.  Scale up to 40-60mg daily and monitor blood pressure.  I recommend using these in cycles 2-3months on and 1-2 months off.

The other ideal peptide would be cerebrolysin.  If/when it becomes available via a stateside pharmacy, this would be ideal.  Cerebrolysin contains p21, BDNF and a host of other neurotropics that will help to promote neurogenesis and growth.

Let us know how this works if you impliment it.

Abid

[Aaron Hartman]

Thanks for the input, I’m starting BCP, TA-1 and will work my way up.

Any ideas/rec’s for layering or implementing these?

[Aaron Hartman]

Any recommendations on Cerebrolysin dosing for this? I have some currently and see a wide range in recommendations but nothing specific for old brain injury, like CP.

[Abid Husain]

I haven’t seen any dosing recommendations for CP so I can only make an estimate.  Extrapolating the dosing schedules for other chronic conditions would lead me recommend 30-50ml IV 5 days per week for 4 weeks done 2-3 times per year.  Infuse with saline in 100-250 ml bag and use a filter in case some of the peptide has precipitated out of the suspension.

[Aaron Hartman]

Awesome, thanks

[Kristelle Reyes]

Claim your CME here: https://earnc.me/knjdg6

[Alyx Huffman]

Hello, has anyone had specific experience using peptide therapy with young CP patients (babies/toddlers)? We have a patient who is 17 months old. She was born premature at 24 weeks (mother had preeclampsia) and developed meningitis. Her grandmother helps to take care of her and reports that her CP is not severe; the child is spastic but can still  move nd her arms nd legs are not crossed. She eats normally and has no issues swallowing. She has a seizure 1 month ago; it was her first seizure. Any guidance/ research anyone has available would be greatly appreciated. Thank you.

[Aaron Hartman]

Alyx,

I have done a lot with my 17 year old daughter and other patients with varying degrees of CP. At her age, I’d focus 1st on lipid therapy including some advanced lipid membrane testing. HBOT also can be super helpful to stop ongoing neural inflammation, if the family has the money for HBOT. Low pressure HBOT at 1.3ATM also has literature on it (even as low at 1.15ATM in alzheimer animal models).

Obviously all the gut stuff as well, with a brain injury in utero, the child will have gut issues.

On the peptide part, Cerebrolysin can be good. I give it to my daughter twice weekly IM but I had to order it from Austria and have it sent directly to my office.

Thymulin would be useful to abait the neural inflammation and Intense PT can be super helpful. NMS, PowerDot or other forms of stimiluation will abate the spasticity over time as well.

 

Hope this helps

Aaron

[Mitchell Fleisher, M.D., D.Ht., D.A.B.F.M.]

Updated protocol for CP:

ProdromeNeuro 4 capsules initially every morning with food; advance to 6 capsules after 4 weeks.

ProdromeGlia 4 ml in food initially after the evening meal; advance to 6 ml after 4 weeks.

ProdromeGTA 3 capsules po BID

Astaxanthol 3 capsules po BID (PGL, 800-527-9512, order #7876)

Thymosin Beta-4 0.25 ml SQ BID, 3 months on and 1 month off

Thymulin 0.25 ml SQ BID ongoing

BPC-157 500 mcg po BID ongoing

Best, Mitch

 

[tim blend]

I know this is quite different but any thoughts for treatment of PSP which the medical community only seems to treatsymtomatically  with PD like drugs or nothing? this 65 yo male patient has significant balance problems along with dysarthria and ocular symptoms.

 

[Author]

Posts