CJC/Ipamoralin

[Bruce Sloane]

What is the proper cycling of CJC/Ipamoralin for general wellness: how many months on/off? Once a year? Thanks

[Kristelle Reyes]

Hello doctors @cpaigepaigemd-com @tl2bactivegmail-com, would love to have your inputs here. Thank you! 🙂

[Madison Lepore]

Growth Hormone:

• Secreted from secretagogue in anterior pituitary
• As we age there is a decrease in GH and IGF-1 which leads to a decrease in cell efficiency
• Hypothalamus secretes GHRH that signals the anterior pituitary secretagogue to start making GH and attempt to release but somatostatin from the hypothalamus has inhibitory effect on the release. To ensure this release within 20 minutes a sub q injection of a GHRP is utilized to release this inhibition. It also has synergizing effects with the GHRH making the amplitude and pulse of the GH release bigger from the anterior pituitary
• Works by activation of ERK1/2 and JAK/STAT3 signaling pathways

CJC-1295/Ipamorelin

• GHRH/GHRP
• Mimics pulse and amplitude of your own GH release
• Optimizes NAD+/NADH pool, NADP/NADPH pool, SIRT and FOXO gene activation, beta oxidation of fatty acids, TCA cycle, oxidative phosphorylation
• Activates signal cascading of AMPK, PCG-1alpha, PPAR-gamma, alpha, NFR1 &2 and TFAM
• Decreases IL2, IL6 and upregulates IL10
• Blocks transcription of NF-kB
• Pleiotropic effects – through GH receptor and GHRH Receptors
• CJC-1295 (Current CJC1295 from pharmacy is MOD GFR(1-29) without DAC )
  • 29 amino acids
  • True CJC 1292 is MOD GRF (1-29) also known as CJC 1295 with DAC (Drug affinity complex)
  • Analogue of GHRH
  • Promotes muscle growth and fat burning
  • Helpful in people looking to slow aging
  • May improve sleep
  • Makes the pituitary follow a natural pulsatile release
  • Can be dosed twice/week at 100mcg or 100mcg daily if treatment is short-term
• Ipamorelin
  • Suppresses somatostatin
  • Increases bone growth

Dosing:

• 1 mcg/kg
• Saturation dose of 100mcg is typically used
• Typical dosing varies from 3 times a day to once a day depending on desired results.
• Cycling
  • 5 days on and 2 days off can run continuous with this protocol.
  • Alternative is 7 days a week for 12 weeks then 6 weeks off and repeat

When giving any GHRH/GHRP it is extremely important to discuss timing with the patients. The patient can take it first thing in the morning and wait 20-30 minutes to eat and then in the evening once they have gone 1.5 hours without eating. Fats and Carbohydrates will blunt GH release, proteins have no effect. For patients looking for muscle gain and fat loss they can take a dose within 90 minutes after exercise.

Dr. Seeds Peptide Therapy: Foundation course has a great overview of GHRH/GHRP for you to refer back to and reference!

Peptide Therapy: Foundation

 

@bbsloanecomcast-net

 

[Bruce Sloane]

Thank you!

 

[Kristelle Reyes]

Claim your CME here: https://earnc.me/476eq5

[Marc Rodriguez]

During the Peptide intense course Dr.Seeds mentioned rotating off of the GHRH/GHRP combos. So doing 5 day on 2 days off maybe use for 4-6months then have an off cycle for some time. How long is the typically on off cycle for the combo GHRH/GHRP? Also he mentioned that one of the components could be used indefinitely. I believe it was the GHRP that can safely be taken year round with no off cycling. Is that correct with the GHRP?

[Kristelle Reyes]

@madisonseeds-md 🙂

[Madison Lepore]

The GHRH can be taken year round no receptor issues.

They GHRP is the one we try to rotate or take a few days off a week like you have referenced.

Possible routine: 9 months rotate these 

• Tesamorelin 
  • 1.25 mg (50 IU’s ) Daily am
    • Do this for 3 months – 7 days a week 
• CJC-1295/ Ipamorelin 
  • 100 Mcg (5 IU’s) every AM & PM
  • Can also add third dose before or after a workout
    • Do this for 3 months-5 days out of 7 
• GHRP -MK0677
  • 12.5 mg Orally BID
    • Do this for 3 months-5 days out of 7

There are some other ways to go but this is a great start. 

You also could  just go CJC/Ipamorelin 3 months on  and take 6 week break and then repeat.

Wellnessivinfusions@gmail.com

Thank you! 🙂

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