Hoping that one of the brilliant minds can walk me through what is going on with a new case I have
29 yr old female, May 2024 prescribed Cipro to treat UTI, after failed antibiotic treatment with Macrobid. 4 days into Cipro, she had bilateral achilles tendonitis and stopped on the 5th day of treatment. She describes she had “whole body tendonitis” – affecting really any joint that has been used more; symptoms can also be random migratory. Associated symptoms include eye floaters and visual “snow” , alternating constipation/ diarrhea, hair loss and significant mm wasting due to the dramatic decrease in activity and function. Symptoms were so severe that she had to take medical leave from her job for several months; during this time she went to physical therapy and slowly and very methodically increases her activity.
Has had extensive workup -neuro, rheum, ophtho, finally went o Mayo and was told that she has fibromyalgia
She has a history of hypermobility, but never had any issues with joint pain or injuries prior to this. somewhere along the way she has developed moderately severe histamine issues – with sun exposure and meals as her biggest triggers. She sees an allergist.
I cannot get her histamine symptoms under control with low histamine diet, Xyzal in am , Allegra inPM, HistaQuel : we tried ketotifen – but after a few days of using the ketotifen, she experienced joint and muscle pain, that was different then the pain from FQ- tendonitis. Same thing happened with Naltrexone 0.5 mg, and Cromolyn ( prescribed by allergist). However, the symptoms from the cromalyn started after weeks of taking vs days with the LDN and Ketotifen.
+mold IgE antibodies,
no hx of tick bites but does live an in endemic area, so I will test now.
COVID antibodies are pending.
Any insight as to what is going on here with either the FQ-tendonitis affecting so many joints for so long? or as to what this reaction of joint and muscle pain to different medications?
I have her on Body BioPC, DFH ultimate antiox, GI Detox charcoal + binder , DHA/ EPA, b-complex she is going to try Singulair. I have discussed neural regulation and Primal Trust with her, she is starting..
I was thinking of starting KPV – any reason not to? or other thoughts with address mast cell activation? — is there value in pursuing an official EDS diagnosis? Support mitochondria with CoQ10, alpha-KG, and maybe NMN?
I would like to start her on some antifungals, BPC (at some point)…
any suggestions or thoughts would be great! thank you!
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