GHK-Cu

[Tammara Beeghly]

I have used GHK-Cu topically for hair regrowth with moderate success for patients.  I have not used it as an injectable for that treatment and would like to know if anyone has, and if so, did you have better results than the topical?

Thank you, in advance, for your help and support.

Tammara Beeghly, Ph.D., PA-C

[Kristelle Reyes]

Hello @leonard-pastranagmail-com and @drkriswyahoo-com, would love to have your insights here. Thank you! 🙂

[Leonard Pastrana]

I have seen success in combination with zinc thymulin, PTD-DMB, and valproate.

Protocol from attached picture was:

TA-1 50 units twice weekly

GHK-Cu/Zinc Thymulin Shampoo daily with scalp exfoliator

PTD-DMB Foam at bedtime in areas of needed hair growth followed by derma roller then

Valproate/Latanoprost solution 1-2 MLS in affected area.

 

 

Topical Peptides for Hair Growth

• PTD-DMP
• Valproate (works synergistically with PTD-DMB)
• GHK-Cu
• Zinc Thymulin

Clinical Research

PTD-DMP 0.01%

• Activation of the Wnt/B-catenin pathway rescues the DHT-induced suppression of the hair follicle. (7)
• Wnt-pathway has been shown to not only speed up hair growth but create whole new hair follicles
• Co-treatment with PTD-DBM and Valproate enhanced hair regrowth much more efficiently than treatment with minoxidil alone. (7)

 

Valproate:

• Wnt/B-catenin pathway Activator
• Synergistic effects when combined with PTD-DMP(7)
• Promotes human hair follicle cell proliferation (8)

 

Latanoprost

• recruits new hairs into the growth phase. (9)
• Significantly increased vellus and terminal hair density at 24 weeks compared with baseline and placebo treated area. (9)

 

CHK-Cu

• Increases hair growth and thickness. (6)
• Enlarges hair follicle size. (6)
• No rebound effect as seen with minoxidil
• Stimulates proliferation of dermal fibroblasts. (6)

Zinc Thymulin

• Topical applications demonstrated safety and efficacy for initiating and maintaining anagen (the active growth phase of a hair follicle) when applied for greater than 6 months. (1)
• Studies have shown significantly less zinc and copper in the hair alopecia patients. (3)
• Zinc-Thymulin showed a significant increase number of intermediate hairs that had progressed from the absent hair stage indicating widespread hair follicle activation. (1)

 

References

1. Vickers ER (2017) An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin to treat Androgenetic Alopecia. Hair Ther Transplant 7: 147. doi:10.4172/2167-0951.1000147
2. Meier N, Langan D, Hilbig H, Bodo E, Farjo NP, et al. (2012) Thymic peptides differentially modulate human hair follicle growth. J Invest Dermatol 132: 1516-1519.
3. Ozturk P, Kurutas E, Ataseven A, Dokur N, Gumusalan Y, et al. (2014) BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia. J Trace Elem Med Biol 28: 266-270.
4. Famenini S, Goh C (2014) Evidence for supplemental treatments in androgenetic alopecia. J Drugs Dermatol 13: 809-812.
5. Hogg CJ, Vickers ER, Rogers TL (2005) Determination of testosterone in saliva and blow of bottlenose dolphins (Tursiops truncatus) using liquid chromatography–mass spectrometry. J Chromatog B 814: 339-346.
6. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.
7. Soung-Hoon Lee, Seol Hwa Seo, Dong-Hwan Lee, Long-Quan Pi, Won-Soo Lee, Kang-Yell Choi,

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis,

8. Jo SJ, Choi SJ, Yoon SY, Lee JY, Park WS, Park PJ, et al. Valproic acid promotes human hair growth in in vitro culture model. J Dermatol Sci 2013;72: 16e24.
9. Blume-Peytavi U, Lönnfors S, Hillmann K, Garcia Bartels N. A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia. J Am Acad Dermatol. 2012 May;66(5):794-800. doi: 10.1016/j.jaad.2011.05.026. Epub 2011 Aug 27. PMID: 21875758.
10. Völker JM, Koch N, Becker M, Klenk A. Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review. Skin Pharmacol Physiol. 2020;33(3):93-109. doi: 10.1159/000508228. Epub 2020 Jun 29. PMID: 32599587.
11. Amirfakhryan E, Davarnia B, Jeddi F, Najafzadeh N. Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1and Gli2mRNA and Shh protein. Avicenna J Phytomed. 2020;10(5):460-471.
12. Poonkiat Suchonwanit, Wimolsiri Iamsumang & Kanchana Leerunyakul (2020): Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature, Journal of Dermatological Treatment, DOI: 10.1080/09546634.2020.1782324
13. Sharma, A, Goren, A, Dhurat, R, et al. Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes. Dermatologic Therapy. 2019; 32:e12915. https://doi.org/10.1111/dth.12915

 

 

 

[Tammara Beeghly]

Thank you, Leonard!!

[William Seeds, MD]

Hey @leonard-pastranagmail-com thank you for that great protocol and response!

[Amber Krogsrud]

Thank you for this information! Also any idea how to reduce burning sensation of GHK-cu when injecting? Can you dilute with more bacteriostatic water? Or is there a better way?

Thank you!

[Kristelle Reyes]

Claim your CME here: https://earnc.me/fPt5Rn

[William Seeds, MD]

also included TB-4 25 IUS – twice a week

 

TA-1 and TB4 was for 8 weeks

After 8 weeks cycle to half this dosing

Also include calcium-magnesium-butyrate working up to 6 pills daily

[Linda Lea]

Great information! What is the dose in mcg or grams of the TB4 and TA1?
I didn’t see the mg if the vile or dilution.
Thank you!

[Author]

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