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GHK-Cu Injection pain

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GHK-Cu Injection pain

Jill White October 22, 2025 at 9:41 am
2 replies 2 months ago

2 Replies

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  • #40664
    Jill White
    Member
    SSRP Certified

    I have heard that drawing up BPC-157 with GHK-Cu can alleviate the pain response to the GHK-Cu injection alone.

    Does anyone have insight? Would that render the peptides inactive or if it is done directly prior to injecting is it ok?

     

    Thank you, Jill White, PharmD

    #40665
    Siobhan Newman, MD
    Member
    SSRP Certified

    Hello,

    I personally do not us NAD+ SC. I do use 1-mna orally as I believe it is safer. NAD+ excess can actually increase inflammation. 1 MNA, by inhibiting NNMT activity, epreserves nicotinamide availability for the NAD salvage pathway, optimizing endogenous NAD production rather than merely supplementing substrate pool. Also if they can tolerate Nicotinic Acid, I build up their reserves slowly 100mg nightly for 4 weeks then increase by 100mg every 4 weeks. Taking it with ASA and food helps too.

    GHk-CU SC – 1mg daily for 6 weeks post surgery to help wound healing, stimulate collagen and fibroblasts. I often then convert to a topical application if possible.

    BPC-157 SC – 300 micrograms once or twice daily for 4-6 weeks. I try to continue the BPC-157 orally at the same time. For so many reasons….fibroblast migration and angiogenesis through VEGFR2. This also improves nerve growth. Orally, this is improving gastric lining and supporting the microbiome.

    I also use Thymosin Beta 4 SC – 750 micrograms once daily for 4-6 weeks. I know Dr. Seeds has recommended 300 micrograms.  This promotes collagen deposits, angiogenesis, tissue healing and is antimicrobial. I always cycle the TB4 on/off and never continuous.

    I basically go through 1 bottle of each as long as my patient is optimized and has good wound healing results. If not I may consider using the BPC-157 SC longer.

    I hope this helps,

    Dr. Siobhan

    #40666
    Siobhan Newman, MD
    Member
    SSRP Certified

    Sorry, that reply was about post surgical use of these. I have never combined BPC 157 with GK CU injections.

    BPC-157 usually doesn’t hurt.

    If GKCU injection hurts then it is probably acidic. Thymosin Alpha 1 is often acidic and painful, just inject slower and warn the patient.

    I hope this helps,

    Dr. Siobhan

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