Hi Beth,
A male patient I prescribe CJC/IPA 100mcg qhs experienced insomnia shortly after starting. I halved the dose and temporarily changed from bedtime to morning. After one week the sleep improved. I continued at the 1/2 dose and switched back to qhs. He did fine so we increased the dose back to the original 100mcg without issue. Because of this, as a general rule, whenever starting GHRH/GHRP, I always do a couple of weeks of morning only dosing before switching to bedtime.
No anecdotal experience for worsening hot flashes after starting a GHRP/GHRH…
Seth