We still do not have a specific cause for the nerve damage that occurs in GBS, but we know the persons immune system begins to attack the body itself. Majority of cases of Guillain-Barre Syndrome (GBS) the immune system damages the myelin sheath that surrounds the axons of many peripheral nerves. In some cases, GBS can actually damage the axon itself. The result of the damage means that nerves are unable to transmit signals efficiently which results in eventual muscle atrophy. Since GBS damages the nerves it is possible for patients to develop paresthesias and pain. Bacterial or viral infections could be a cause of GBS. There have been times where surgery or vaccinations could increase the risk of GBS. Zika virus has been reported as a cause of GBS.
You are on the right path by starting him on the immune peptides TA1 and TB4. He should remain on those peptides. Are you able to provide an update as to how he is doing since starting the TA1 and TB4? Both work on myelin sheath regeneration which is important for this patient.
Adding the pentadecapeptide BPC-157 could be beneficial for this patient. BPC-157 is a gastric peptide but it has been used to help in various CNS-disorders. It is cytoprotective. BPC has a stimulatory effect on the Egr-1 gene, NPB2 gene, FAK-paxillin and JAK-2 signaling pathways. When given peripherally BPC-157 induces a release of serotonin, specifically nigrostriatal regions. This release of serotonin has an influence on serotonergic and dopaminergic systems. It also protects somatosensory neurons and improves nerve regeneration.
Also adding on CJC/Ipamorelin, which is a GHRH/GHRP would be extremely helpful for this patient. Administration of CJC/Ipa works on the anterior pituitary and will stimulate the pulsatile release of endogenous GH. CJC/Ipamorelin keeps a balance of AMPK and mTOR and helps with protein synthesis. You can start this patient on 5 IUs in the AM and 5 IUs in the PM.
It would also not be a bad idea to have the patient supplementing with phospholipids, such as Sunflower Lecithin. Ideally, he would take 5-10 grams/day. The Lecithin comes in pills, powders or oils.
ProdromeGlia-a plasmalogen precursor (Alkylglycerol), is another supplement that could help the patient out. Glia insulates neurons. It helps boost the patients Omega-9 and is a pre-cursor for your peroxisomes to make plasmalogens. They can take 30 drops in the evening with food. The CJC/IPA works on improving your mitochondrial and peroxisomal function so by supplementing ProdromeGlia you are giving your body the building blocks that it needs.
Make sure the patient is on a B-vitamin complex and B-12 vitamin. Preferably sublingual that way it is absorbed directly in the blood stream and does not need to be digested in the stomach before getting to the liver.
Here is a great overview of Guillain-Barre syndrome: “Guillain-Barré Syndrome Fact Sheet | National Institute of Neurological Disorders and Stroke.” Accessed October 8, 2021. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Guillain-Barr%C3%A9-Syndrome-Fact-Sheet.
Sikiric, Predrag, Sven Seiwerth, Rudolf Rucman, Danijela Kolenc, Lovorka Batelja Vuletic, Domagoj Drmic, Tihomir Grgic, et al. “Brain-Gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.” Current Neuropharmacology 14, no. 8 (November 2016): 857–65. https://doi.org/10.2174/1570159X13666160502153022.
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