It sounds like there may be some confusion between Thymulin (which is fairly similar to Thymosin alpha 1, abbrev TA1.
Dr. Seeds talked quite a bit in the early Dec. Mastermind at Jackson Hole Wyoming (2022).
TA-1 originally replaced Thymulin, and now the reverse has happened. TB4 is quite different from Thymulin/TA-1, and is overexpressed by some cancers, can also have some immune suppressive activity, depending on context, and activity of chronically expressed inflammosomes, which can be stimulate cancer if it is present, but latent. In her case, you have an easy to test marker of her malignant activity, simply by measuring her absolute LGL cells. This is why I suggested to optimize eveything else, and to start with Thymulin.
below are some notes from Dr. Seeds discussion of a case of chronic neck pain which shares some of the underlying principles regarding management of active Inflammasomes, which might be useful. Wherever he says TA-1 below, substitute thymulin.
Hope this is helpful.
Dwight
well first we need to make a couple of assumptions. When I have this type of patient I feel they all have auto immune issues and in -particular the Inflammasome is active producing IL-1 B , Interleukin 6, TNF-alpha and other cytokines and Chemokines . There is an up-regulation of the innate immune system and we need to spend some time working on this first. this is were I am most successful wit the use of TA1 and BPC. I will use just these peptides for 2- 6 weeks until I feel the inflammasome is under better control .
By Using a GHRH/GHRP in this situation is not beneficial in the beginning and can make things worse in this type of patient. There are GH and IGF-1 receptors on the inflammasome that can be beneficial but also can upregulate the pro inflammatory state.
so typically I start at TA1 at 1.5mg daily for 2 weeks with BPC 500mcg BID and then re-access. I may continue another 2 weeks and assess. but typically I will wait 6 weeks before considering a GHRH/GHRP.
If there is nerve ,radicular, pain from the neck or nerve pain I will add TB 4 and I use any where from 300mcg – 900mcg a day and I inject in the subq of the painful neck area.
I am assuming these patients are in a sub clinical depression or overt depression. Current research is compelling indicating a bigger role as a pro inflammatory cause!
Jha, M., & Trivedi, M. (2018). Personalized Antidepressant Selection and Pathway to Novel Treatments: Clinical Utility of Targeting Inflammation. International Journal of Molecular Sciences, 19(1), 233.
The above protocol works in this area also .
Patients are also typically in an anxiety state and the peptide Selank can be very helpful as a nasal spray. Also has auto- immune properties and helps with taking patients off of narcotics, alcohol, anxiolytics .
As time progresses i will then consider adding other peptides first A GHRP as there are more pro cellular survival pathways usually 100mcg at bed and upon awaking in the am. . And from here continue to Build . possibly add the GHRH a month later .
Sleep is also a big player in this process and with significant Brain Inflammation from all the above noted DSIP and Epitalon can be a great combination addressing the circadian clock and improving stage 4 sleep . this step at the right time continues to be a game changer in progression of theses patients. Some times just the use of DSIP is enough. Typically 100 mcg sub q before bed.
hopefully a few steps to get you on the right road.
I also believe Glucose metabolism is in despair in the Brain and Body with decreased PDH (Pyruvate Dehydrogenase) activity. and up regulation of PDH4. we see this with aging and many disease processes. This is where Ketone esters can be utilized as the cellular substrate to start making the cell more efficient and help it promote transcriptive state that is more anti inflammatory and improve the current pro oxidative state of the cell. Over time we will be helping to improve glucose utilization and Insulin sensitivity of the cell but the Ketone ester lets us improve cell function while we are waiting for these cellular corrections that take time .
I have been able to achieve a lot early on as I am correcting pathways with peptides and at the same time taking advantage of an energy substrate the cell will preference and use to not only function at a more efficient level but also transform the cell to better deal with ROS.
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