Lyme muscle/joint pain

[Berna]

Hello,

I’ve got a client who is probably about 4 to 5 months into his Lyme treatment with me. He has been doing well but his pain is increasing lately. I haven’t used peptides for support in Lymes disease but have convinced myself that Thymosin alpha one and TB-4 frag (500) are the way to go. He does have a history of sarcoidosis as well.  I would have considered ozone but right now I am sending him to rule out hemochromatosis due to abnormal iron panel including ferritin.

Should I consider starting with oral BPC-157 first and then add the above?

 

Thank you!

Berna DeMalignon, MD

[Cynthia Keller]

Berna-

 

I worry about not knowing what is causing the worsening pain before deciding the appropriate next steps.

-If the pain got worse with treatment, the issue could be die off… so slow down, back off tx, and get better detox.

-If the pain is more muscular (in the tissue) then my money is on a recent mycotoxin exposure (inc MMP9, which leaches toxins into soft tissue causing muscle pain).  Tx here is detox and binding.

-If the pain is more their own “this is my typical Lyme joint pain” just worse… then a) the current treatment is not the correct one,      b) and I would consider adding LL-37 and TA1 trial *

-I would not do ozone until you are sure of what you are trying to do.  You wouldn’t want to use it to kill more spirochetes, etc…if the worsening the patient was having was already about die off.  Etc.

 

*Pls note as I have mentioned before, be careful about using TA1 in someone with TBD without including LL-37 at least in the beginning.  Since maybe the inflammation is the only thing holding Lyme at least partially under control.  You wouldn’t want to “modulate” the immune system and decrease the inflammation until you were also helping the body be better at killing directly.  The body is smart and was likely doing the best it could with what it had to keep the spirochetes suppressed.  Inflammation can do this to some degree.  Sometimes 2-3 days of LL-37 before TA1 makes all the difference (someone with TBD getting better -vs- worse with TA1)

I love BPC for all kinds of things.  But again, for me… I do not spend the patient money until I can speak clearly about what my goal/target is.  And for this patient… if you are worried primarily about the pain, I think it is hard to know what to start until you know what the problem is (as mentioned above).

Lastly, I will say, that treating patients with TBD is tricky. And they are a hard bunch to do trial and error on (their systems are often not that forgiving and you can easily make them worse. And recovering from “worse” can be very long and hard for them).  So if able/whenever possible I recommend finding someone to learn from if you plan to help more people with TBD in the future.  Also, ILADS can be a very helpful resource when working with getting started in that field.

Hope that helps

Cynthia

[Berna]

Thanks Cynthia! Appreciate the framework you’ve provided.

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