Hi Lisa! I apologize in advance for the long answer!
The good news is that the SIRT1 gene should be functional. It regulates the FOXO3 which has the dysfunction. Downstream you have likely dysfunctional SOD2 (mitochondria), slightly dysfunctional GPX and functional CAT. SOD is regulated by your likely dysfunctional FOXO3. SOD2 converts the superoxide radical into molecular O2 and H2O2. CAT, primarily, and GPX protect the cell from ROS by converting the H2O2 to water and O2. Since your CAT is likely functional and it is the most important. You should focus on fixing SOD2 with vitamin E (containing alpha, beta, gamma and delta tocopherols) will improve lipid peroxidation in the liver and/or astaxanthin will increase SOD activity. Upregulating PGC-1A also increases SOD2, CAT and GPX1. PGC-1A can be activated by cold, fasting, calorie restriction, reduced carbs, NAC, NAD, Omega 3, butyrate, prebiotic fiber such as guar gum and exercise. Exercise will increase PGC-1A expression 50% – 7-10X following a single bout of exercise. One study showed 2-min of exhaustive exercise corresponds with increased PGC-1A mRNA expression 7-10X, which peaks at around 2 h. Another recently reported 1.5X increases in PGC-1A mRNA levels in men and women after a 16-wk exercise training program consisting of stationary cycling (3–4 sessions/wk at 70–80% maximum heart rate), and another reported increases of 2.7X after 6 wk of running training. Resveratrol will also increase PGC-1A by decreasing its acetylation.
As for peptides, I would work on the inflammation and gut first with BPC-157 oral or sq. I would add what you can from the above list of supplements along with exercise.
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