Measuring Cell Senescence

[PATRICK FREE]

Do any of you use laboratory markers or phase angle measurements to assess cellular senescence? The literature seems to suggest that SA-β-Gal and SAHF would be possible reliable markers, but I am guessing these are fairly costly labs to obtain; or could one use inflammatory markers as an indirect measure, as those with a suspected SASP would most likely present in a more profound inflammatory state? Thank you.

[Jamie Costello]

Hi Patrick! I have been using SA-B-Gal for some time to measure senescence. I think it is effective but not cheap. I have been using the Aging SOS test which include intra and extracellular NAD. It would be nice to have a standard protocol that we all use and get a discount. The bulk of the Aging SOS test is too expensive when I truly only want the NAD and SA-B-Gal. Jamie

[PATRICK FREE]

Thank you Jamie. Much appreciated. Do you have any experience with using a phase angle measurement on a body composition test to measure senescence? Thank you.

[Jamie Costello]

Hi Patrick

I use phase angle for measuring cell regeneration. I never thought of it for senescence. I suppose a good phase angle would be indicative of less senescence. I think from what I have seen in my practice, this makes sense to use a general marker. However, I still thing the gold standard may be the SABG test.

Jamie

[Claude Fortin]

I have started to use jinfiniti for the SabG test. Are there other commercially available tests?

[Leonid Gordin]

Hello all,I use Jinfiniti lab for NAD testing.

What is SabG test and how much does it cost?

Thank you, Leonid Gordin

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