Dear Colleagues,
My understanding is that in order to cross cellular membrane, methylene blue needs to be in reduced form. Does it mean that once it happened, it turns into oxidized form? In other words, is it an oxidized form in cytoplasm and again it reaches mitochondrial membrane, it has to be reduced again to cross that membrane and then once inside mitochondria, it becomes blue (oxidized again)?
It reminds me redox changes of copper in terms of GI absorption, transport and cellular absorption. If that is the case with MB, what is redox couple that allows this MB redox shift? I can see how ascorbic acid can do this by facilitating reduction. There is not only scientific but above all clinical reason why I want this clarify. In my clinic practice, I’ve been using MB IV and orally. My patients find it quite helpful. From talking to my colleagues, I have learned about combining IV ozone and MB ozone administered first, and once it’s given, MB follows.
They claimed that administered this way, MB works better than just by itself. Do you think that using ozone helps to promote oxidized form of MB? Would you speculate that MB would work better after vitamin C or glutathione or alpha lipoic acid infusions? In my mind, it would keep it in more reduced state. In other words, I tried to understand if use of those redox active nutrients can optimize the beneficial effect of MB on mitochondria via energetics.
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