over active bladder

[PATRICK FREE]

Good evening. I have a 44 y/o male that has been dx with overactive bladder, seen a number of different urologists, tried nearly every pharmaceutical with no relief. I was going to start him on pentosan polysulfate. He was interested in using a chitmour complex A-12 that he found on the internet. I am not familiar with this peptide. Has anybody used this peptide? Thank you.

[Linda Kiley]

Make him do a full 3 day bladder diary first.  Measure and record all fluid intake and output of urine for 3 days.  OAB is often misdiagnosed and you need to know exactly what you are dealing with.  It could be anything from excessive fluid intake to diabetes insipidus to interstitial cystitis (does not require pain for diagnosis). Don’t treat until you personally have made the diagnosis.  I don’t believe anyone any more.

[Giovanni Silva]

Agreed, overactive-bladder is quite often misdiagnosed. You really have to ask yourself, if your patient has truly “seen a number of different urologists, and has tried nearly every pharmaceutical with no relief”, most likely it’s not really OAB.  Also, diabetes insipidus terminology has changed to “Arginine Vasopressin Deficiency” (AVP-D) for central etiologies and “Arginine Vasopressin Resistance” (AVP-R) for nephrogenic etiologies.

Quite a few patients with polyuria can have deficient secretion and/or end-organ effects of the hormone arginine vasopressin. Another visual sign I look foreign this population of patients is increased fine lines on the forehead and around the eyes secondary to dehydration. This is what people get injected with Botox, when the true mechanism is dehydration of the skin, secondary to lack of vasopressin hormone secretion.

[Giovanni Silva]

Correction to above statement:

“I look for (not foreign) in this population patients…………”

[Kristelle Reyes]

Thank you for your great insights, Linda and Giovanni!

Hello @byurthgmail-com, @drhusaininterlinkedmd-com, @leonard-pastranagmail-com, @drkriswyahoo-com, @andkeller2gmail-com, @dr-siobhannewmangmail-com, and @cpaigepaigemd-com, we would love to have your inputs here as well. Thank you!

[Author]

Posts