Peptide Protocol for Fibrosis and Cardiac Muscle Function

[Kristelle Reyes]

From: @drgraftonyahoo-com

My daughter is a cardiologist who deals with heart failure and puts these pumps in the patients while they wait for a heart transplant. And she says that fibrosis is a big reason. For the failure I was trying to come up with a protocol that she could use to see if we can get some reversal or decrease in the fibrosis in the cardiac muscle I was thinking along the lines of BPC-157, T500. And some growth hormone. Igf1 lr3 or tesamorelin. Or a different one to increase.. Cardiac muscle function if Dr. Seeds has any suggestions I would appreciate. There would be either exosomes. Or stem cells added to the program. To any articles along these lines would also be appreciated. Maybe we can get. Some results by spring. Thank you as always??

@drhusaininterlinkedmd-com and @cpaigepaigemd-com, would love to have your insights here. Thank you! 🙂

[Abid Husain]

Hi Dr Grafton,

You’ve got the right idea with the peptides you’ve selected.  The combination of BPC-157, Thymosin Beta 4, and CJC/Ipamorelin are a great base to start with.  A cycle of IGF-1LR quarterly will also be beneficial.

The challenge here is that heart failure patients that have implantable cardiac support devices are on the far end of the spectrum of fibrosis.  These are patients who have mostly fibroitic tissue instead of functional cardiac muscle.  The expectation of changing their course is low in this kind of extreme situation.  The peptides will work best in prevention of fibrosis in healing from myocardial infarctions but chronic fibrotic changes are much more challenging and would likely require years of treatment to show reversal.  When patients have assist devices, they are at the end of the line and may not have that much time available to them.  It is certainly worth a try and peptides would be a great adjunct to conventional therapy.

Hope that helps,

Abid

[Kristelle Reyes]

Hello @drgraftonyahoo-com,

Here’s another response from Dr. Seeds’ SSRP Office Hours 11/02/21 at 04:18 please watch below:

 

Thank you! 🙂

[Kristelle Reyes]

Claim your CME here: https://earnc.me/xvebbs

[Jason Schmidthuber]

Do we believe the above combination could also reverse fibrosis in the setting of post MI and revascularization?

[Abid Husain]

Hi Jason,

Yes.  Studies show that the combination of BPC and TB4 will increase angiogenesis, improve nitric oxide, recruit cardiac progenitor cells and promote the deposition of organized collagen / connective tissue.  Preventing fibrosis will prevent remodeling and the  later onset of heart failure.  CJC/ipamorelin will also aid in the prevention of these processes.  All three will attenuate inflammation with is central the the advancement of fibrosis to heart failure.

The addition of CJC/ipamorelin will also improve the situation via attenuation of angiotensin 2 pathways and stimulating PPAR gamma pathways.

The reversal process would likely happen but it depends how far into the progression of disease the patient is.  I would recommend starting the above peptides and cycle them continuously for a few years, monitoring progress with echos and exercise testing annually.

Hope that helps,

Abid

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