Semaglutide dosage for weight loss

[Karin Lucas]

Has anyone heard of compounded injectable Semaglutide/ BPC 157/ B6   1.25mg/1.25mg/40mg/ml ?  There is a compounding pharmacy promoting this formula with directions: 0.2ml to be injected subq daily for 5 out of 7 days per week for one week (this is equivalent to 0.25mg daily or a total of 1.25mg by day 5). In addition, the directions state: may increase to 0.3ml – 0.4ml subq daily as tolerated. I have not seen any research indicating that semaglutide should be given daily (it has a half life of 7 days). I’m wondering if the thought process is that by adding BPC-157 , gastric side effects will be much less and dose escalation not as crucial?? However, lower doses of Semaglutide (0.25mg and 0.5mg) given once weekly have already been shown to be very effective for weight loss. Also, this pharmacy has explained to  practitioners that the injection should be given 30 minutes prior food or 30 minutes after???? The explanation I was told is that it will reduce stomach upset…. I have not heard any information like this before. Any thoughts on this regimen?

[Kristelle Reyes]

Hello @leonard-pastranagmail-com and @drkriswyahoo-com, would love to have your insights here. Thank you! 🙂

[Robb Bird]

I follow the once a week dosing guidelines and have had awesome success with my patients. You are correct, I haven’t seen anything on daily dosing and I bet it can get pricey dosing it like that. Sometimes pharmacies try to create new combinations just to be different. I’d imagine the nausea and other GI stuff would be worse but maybe the BPC helps.

[William Seeds, MD]

@drbirdtransformyou-com

agreed…once a week at 12.5 iu’s has been really effective. I reached out to the pharmacy to confirm @kelfers35gmail-com

[Leonard Pastrana]

I am not aware of any literature using daily subq dosing of semaglutide. Here is the recommended titration schedule for subQ

Week 1-4 0.25mg weekly

week 5-8 0.5mg weekly

week 9-12 1.0mg weekly

week 13-16 1.7mg weekly

week 17+  2.4mg weekly.

*In patients who do not tolerate the dosage increase consider delaying the increase an additional 4 weeks*

The only daily dosing I am aware of is oral semaglutide at much higher dosages.

 

You can take semaglutide with or without food.

Not sure why the BPC is there.

 

https://www.novo-pi.com/wegovy.pdf

 

 

@kelfers35gmail-com I have also seen a lot of success with weight loss at doses of 0.25mg and 0.5mg weekly doses. In my experience, we titrate very few people over 1mg weekly.

GLP-1s can be game-changers if done correctly. The key I have seen so far is to start low and go slow. It’s tremendous in what it can do with eating habits and glucose dynamics. If you start too fast people get way too nauseous and lose interest.

 

 

 

 

 

 

 

 

[Jamie Costello]

Hi Leonard

Here is an article discussing weekly and daily dosing for the GLP-1 agonists. I think this will be helpful in setting the appropriate protocol.

Divino V, Boye KS, Lebrec J, DeKoven M & Norrbacka K. (2019). GLP-1 RA Treatment and Dosing Patterns among type 2 diabetes patients in six countries: a retrospective analysis of Pharmacy claims data. Diabetes Ther. 10:1067-1088. DOI: 10.1007/s13300-019-0615-5

[David Bonfa]

Hello to all,

My name is David Bonfa and I am one of the Co-Founders of CRE8 Pharmacy. I believe the formula in question is one we have created. Allow me to try to help clear up some confusion with regards to dose and suggested protocols.

*** Keep in mind that the Obesity max dose weekly recommended by Ozempic is 2.4mg once a week (2400mcg’s). 

Our formula allow doctors to be flexible in their approach.

Here is a breakdown in case you want to see all the options you have depending on your stance and medical suggestion:

Injection:

Semaglutide / BPC-157 / B6   (1.25mg / 1.25mg / 40mg/ml) – 5ml Vial

• 0.1ml or 10 units on syringe = 125mcg / 125mcg / 4mg
  • This dose will supply you 50 injections per 5ml bottle

• 0.15ml or 15 units on syringe  = 187.5mcg / 187.5mcg / 6mg
  • This dose will supply you 33 injections per 5ml bottle

• 0.2ml or 20 units on syringe  = 250mcg / 250mcg / 8mg
  • This dose will supply you 25 injections per bottle
  • This CAN be used for a 5 day on, 2 day off protocol but in no way do we  recommend protocols. We have simply seen many doctors move to a more daily lower dose approach rather than a higher once a week dose. Please feel free to inject this dose once weekly if you want the patient to receive 250mcg of Semaglutide weekly. That is entirely up to the doctor.
    

• 0.3ml or 30 units on syringe  = 375mcg / 375mcg / 12mg
  • This dose will supply you 16 injections per bottle
  • This can be used for every other day protocol – again just reiterating that this is what some doctors have been prescribing but please feel free to inject this dose once weekly if you want the patient to receive 375mcg of Semaglutide weekly.
    

• 0.4ml or 40 units on syringe  = 500mcg / 500mcg / 16mg
  • This dose will supply you 12 injections
  • This can be used for a once a week injection for 3 months
  • OR you can use the 0.4ml for a once a week injection for weeks 1-4 and titrate to 0.8ml for the weeks 5-8

With regards to the added BPC-157 – this was included in our formula for assistance to gut repair and especially to help joint pain. The B6 helps with nausea.

Please feel free to connect with me at david@cre8rx.com or your representative if you have any other questions.

I hope this helps a little but please reach out to me if you have any other questions.

Thank you!

See below for a comparison conversation guide between the Ozempic and CRE8 Formula dose.

Ozempic Dose                                Conversion to CRE8 Dose

0.25mg (250mcg)                         0.2ml/20 units (0.25mg Semaglutide/0.25mg BPC-157/8mg B6)
0.5mg  (500mcg)                          0.4ml/40 units (0.5mg Semaglutide/0.5mg BPC-157/16mg B6)

1mg (1000mcg)                             0.8ml/80 units (1mg Semaglutide/1mg BPC-157/32mg B6)
2mg (2000mcg)                            1.6ml/160 units(2mg Semaglutide/2mg BPC-157/64mg B6)

[Kris Wusterhausen]

Great info David and Leonard!  We have had great success overall with weekly Semaglutide. We find that many of the patients will have success with the lower doses. I find that its simply all about finding the right dose for most patients. Also adding info Leusynergy from NuBioage has been very helpful as well.

 

Kris Wusterhausen

[David Bonfa]

Thank you Dr. Wusterhausen,

Yes, you are correct! When you get the chance to see what many doctors are prescribing to their patients and getting the desired results you will find the protocol is all over the place. It’s not necessarily a bad thing. At the end of the day I always think its best to start lower and see how they react to it then titrate up after 4 weeks if they can handle it. Have a great day !

David Bonfa

[Karin Lucas]

Thank you all for this helpful information!

Karin

 

[Author]

Posts