Regarding Your Peptide Dosing During Night Shifts:
First, I want to address an important underlying concern: the impact of shift work on your long-term health and longevity. Research consistently shows that disruption of the circadian rhythm—our body’s natural 24-hour cycle—has profound effects on metabolic health, hormone regulation, and disease risk.
Rotating shift work, particularly night shifts, significantly increases your risk for:
- Cardiovascular disease
- Metabolic disorders and obesity
- Type 2 diabetes
- Certain cancers
- Sleep disorders and chronic fatigue
I strongly encourage you to consider transitioning away from shift work if at all possible. While I understand this may not be immediately feasible due to career or financial considerations, it’s crucial that you understand the substantial health risks you’re taking on with this schedule.
That said, here’s how to approach your peptide dosing:
For your GHRP and GHRH peptides (growth hormone-releasing peptides), the key principle is: dose them prior to your main sleep period, regardless of what time of day that occurs.
- On night shift weeks: Take your peptides before your daytime sleep
- On regular weeks: Take your peptides before your nighttime sleep
Critical fasting requirements:
- Take these peptides on an empty stomach (at least 2.5 hours after eating)
- Do not eat for at least 30-60 minutes after injection to optimize effectiveness
- Avoid simple carbohydrates and fats particularly, as they can blunt the growth hormone response
- This is especially important for night shifts workers because shift work leads to carbohydrate cravings and unusual eating patterns.
The goal is to align peptide administration with your actual sleep-wake cycle during each period, rather than trying to maintain a fixed clock time.
Does this clarify your dosing strategy?
Dr. Siobhan
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