I have been working on a theory that could have implications for both fat loss and health span as well as mitochondrial optimization. I would love to hear if anyone else had any experience or had considered the potential synergy between BAM 15, SS31, and MOTSc.
Mitochondrial uncouplers, such as BAM 15, can increase the metabolic activity of mitochondria, leading to increased energy expenditure and potentially triggering mitophagy, a process by which damaged or dysfunctional mitochondria are selectively removed. SS31 and MOTS-c are mitochondrial-targeted peptides that have shown promising effects in various studies. SS31 has been shown to reduce oxidative stress and improve mitochondrial function, while MOTS-c has been associated with enhanced insulin sensitivity and metabolic regulation. Urolithin is a metabolite derived from dietary ellagitannins, found in certain fruits and nuts, that can activate a cellular pathway called the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway, which is involved in mitochondrial biogenesis. By stimulating mitochondrial biogenesis, urolithin could potentially support the generation of new and healthy mitochondria[1][2][3].
MOTS-c is a key regulator of the signaling pathways that initiate mitochondrial biogenesis, including the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway[4]. Studies have shown that the interaction of MOTS-c/NRF2 can improve the expression of mitochondrial protective genes. The aging process could lead to a decrease in MOTS-c levels. In fact, MOTS-c levels in skeletal muscle and blood circulation in both humans and mice decrease with age. Studies have shown that blood MOTS-c levels in young people are 11% and 21% higher than those in middle-and old-aged people, respectively. Systemic injection of MOTS-c can restore the level of MOTS-c in aged mice and successfully reverse age-related physical decline and muscle homeostasis[1][2].
Sources
[1] MOTS-c: A promising mitochondrial-derived peptide for … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905433/
[2] MOTS-c, the Most Recent Mitochondrial Derived Peptide in … https://www.mdpi.com/1422-0067/23/19/11991
[3] Everything you need to know about MOTS-c Mitochondrial … https://yuniquemedical.com/mots-c-peptide/
[4] Mitochondrial Biogenesis: A Therapeutic Target for … https://www.researchgate.net/publication/260644297_Mitochondrial_Biogenesis_A_Therapeutic_Target_for_Neurodevelopmental_Disorders_and_Neurodegenerative_Diseases
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