The pt shows early signs of dementia onset due to severe insomnia in the last 2 years – What peptide protocol could I use to restore sleep, brain detoxification, and restore cognitive function?

[Miguel Bertonatti]

Patient history
The patient has been sleeping 2-3 hours a night for the last two years and is CONVINCED his signs of dementia are due to his severe insomnia. This patient is a high-performing CEO who is struggling with short/long term memory, cognitive performance, and intense brain fog. He reported that he did not have any of these mental issues before experiencing insomnia.

The insomnia was triggered by losing one of the companies that took him into a nose dive of fear and survival. He woke up every day in the middle of the night, fearing he would lose everything and end up in the street. He even considered suicide at one point. Any noise would quickly wake him up because his mind was in extreme vigilant mode, and he felt he was constantly in a “fight or flight” mode. That has created a lot of stress b/c he has not been able to perform again at his full potential due to the lack of sleep and brain fog. Previous to this insomnia issue, he was a happy, thriving CEO, with no family history of ANY neurodegenerative disease. The patient is in excellent physical shape, has a clean diet, and wears blue-blocking glasses at night to prevent melatonin inhibition.

A recent study conducted in older adults reported that insomnia was associated with a significantly increased risk of all-cause dementia. Another recent study also demonstrated that sleep disturbances could enhance the risk of developing dementia, and insomnia may increase the risk of Alzheimer’s disease.

After a lengthy consultation with the patient, he is hopeful he could get back to normal if he gets enough sleep and feels his brain performance back to an optimal state. He is taking Temazepam 30mg capsule before bedtime BUT would like to stop taking it b/c it is not working well & does not want to depend on a sleeping pill to sleep. He is ready to revive his mental state and has a STRONG positive mental outlook on his new future. He is ready to tackle this “new beginning” in his life and would like to try EVERY & ANY peptide protocol to restore his brain function. He is willing to do whatever it takes & MONEY is not an issue for this patient.

Peptide protocol we had in mind to restore his brain function and help him detoxify his brain —- ANY SUGGESTIONS WOULD HELP?

• DSIP 100mcg one hour before bedtime, 5x per week
• Selank – Instill one spray (750mcg) – daily every other day & alternate in between with Selank – 6 wks protocol
• Selank – Instill one spray (750mcg) daily every other day & alternate in between with Semax – 6 wks protocol
• Dihexa – Take 40mgs orally (2 caps) every morning – 6 wks protocol
• CBD oil nightly
• (Optional) FGL – Instill one spray (1,000mcg) in each nostril daily – 6 wks protocol

Would you alternate this protocol differently, or have him do one peptide at a time? Any creative suggestions to help this CEO get back on his horse would be greatly appreciated it.

[Leonard Pastrana]

Miguel, we have seen great results in similar situations with IV ketamine therapy. This overactive, driven personality type can be both a blessing and a curse.  This extreme stress that turns into anxiety and depression can mimic early signs of neurodegenerative disease. We had a very similar case that was completely resolved after 5 treatments of IV ketamine therapy.

We also noticed a big difference in the efficacy of peptide protocols after ketamine therapy due to the reduction in stress, anxiety, and fear that was inhibiting all our interventions.

The protocols look good.

 

[Miguel Bertonatti]

@leonard-pastranagmail-com

 

Yes, you are completely correct. We did recommend him IV ketamin therapy but HE INSIST in trying the peptide route 1st. If that were not to work, he would consider the ketamine therapy. BUT for now, does this peptide protocol look correct? Would you make any alterations to the sequencing of the protocol?

 

 

 

 

[Mitchell Fleisher, M.D., D.Ht., D.A.B.F.M.]

Miguel,

The causation of the CEO’s current state is psychoneurophysiological, and he is an excellent candidate for Constitutional Classical Homeopathic Medical Therapy.  I would be willing to ascertain his Homeopathic simillimum to help you to help him heal more effectively with a synergistic combination of peptide therapy and homeopathy.

Have him go to https://www.cirm1.org/_files/ugd/183f24_38e1d63ebc0c46aba6353c7961f42ab8.pdf and complete the questionnaire.  Then email the completed questionnaire to info@cirm1.org for analysis.

He would also benefit significantly from the following agents:

ProdromeNeuro 4 capsules twice daily with food.

ProdromeGlia 4 ml daily with the evening meal.

Best, Mitch

[Leonard Pastrana]

Quote from Miguel Bertonatti on October 25, 2022, 9:46 am

@leonard-pastranagmail-com

 

Yes, you are completely correct. We did recommend him IV ketamin therapy but HE INSIST in trying the peptide route 1st. If that were not to work, he would consider the ketamine therapy. BUT for now, does this peptide protocol look correct? Would you make any alterations to the sequencing of the protocol?

 

 

 

 

Is he already taking a GHRH/GHRP? A  bedtime dose can improve sleep.

With the DSIP, if it doesn’t initially work with bedtime dosing, you can try taking it early and early in the day. Everyone is different, but some people get the benefit when taken earlier in the day.

We usually alternate selank/semax like you mentioned for a month and then try the Dihexa. This way, we can see what was providing the benefit.

Another option to improve natural melatonin production and sleep is Epithalon:

Epithalon dosing:

10mg daily X 10 days or

5mg daily X 20 days.

 

Keep us posted

[Miguel Bertonatti]

 

@drmitchmdmindspring-com – Thank you Mitchell, good info to know.

@leonard-pastranagmail-com – Thank you Leonard, the DSIP info is very good to know. However, on the Epithalon, any best time to take it? AM or PM?

[Leonard Pastrana]

Epithalon at bedtime

[Abid Husain]

I would also consider using Selank and Semax as a SQ injectible.  Nasal absorption varies from person to person.  Given the hyper-vigilance, it’d be important to maximize the anti-anxiety benefits of Selank.   And it would allow the freedom to scale up doses of Selank and Semax.

The other peptide option for sleep is VIP.  This has more benefit for circadian rhythm disturbances.  This most often available as a nasal spray, so keep absorption variability in mind.  The dose is 2 sprays to each nostril daily prior to 11am.  Later than 11am and it may keep inhibit normal sleep cycles.

Outside of peptides, consider L-Theanine 500-1000mg at bedtime, DHH-B 10-20mg at Bedtime and a high dose adaptogen.

Hope this helps!

Abid

[Marc Rodriguez]

I second the ketamine Iv therapy recommendation. One of the most immediately profound and shifting changes we get from any of the modalities we offer with or without the inclusion of peptides.

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