[deborah dunn]

Thanks Clyde.

I’m dosing 125mg/ml — 1 ml twice weekly ..which he tolerated fine after surgery.   I can ask him to reduce it by 50 percent but would really like to understand the etiology.

It’s curious…

 

Thanks again for responding!  Appreciate it.

Best,

Deborah

 

[deborah dunn]

Hi Anat,

In terms of the Rapa, I believe the low dose data is actually immunostimulatory.

Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB. mTOR inhibition improves immune function in the elderly. Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892. PMID: 25540326.

Here is a skin paper:

Dao V, Liu Y, Pandeswara S, Svatek RS, Gelfond JA, Liu A, Hurez V, Curiel TJ. Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells. Cancer Res. 2016 Oct 15;76(20):5970-5982. doi: 10.1158/0008-5472.CAN-16-0091. Epub 2016 Aug 28. PMID: 27569211; PMCID: PMC5065775.

Best,

DD

 

 

[deborah dunn]

 

Agree with Anat. For chronic substance abuse, it is a game changer after supporting micronutrients, lipid membranes and other cellular pathway mechanisms.

 

[deborah dunn]

Thank you so much Abid! Makes alot of sense.

Thoughts on ARA-290 specifically through the lense of the macrophage?

. Some animal research on decreased macrophage activation, decreased NF-KB, decreased TNF-α and  increasing vascularization into damaged tissue.

Watanabe, Masaaki et al. “A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets.” Transplantation vol. 100,3 (2016): 554-62.

https://www.pnas.org/doi/full/10.1073/pnas.1214099110

doi:10.1097/TP.0000000000001026https://www.sciencedirect.com/science/article/pii/S0041134518302501

[deborah dunn]

Good question Denise,

Perhaps the pharmacists could help direct us. For example, I’m in a small Colorado mountain community with a large tourism base, that has  need to hold on site for example, BPC-157 for an injections secondary to an acute MSK injury or even a TBI from mountain biking/skiing etc. By the time we order and ship etc, we have lost some opportunity. But I”m afraid to inventory

anything nor give without a “prescription in the patient’s name”.  At the same time we have many other drugs we use with comfort including steroid concoctions, hypertensive urgency meds etc.

Am I being to0 cautious in regards to some of the safer Peptides?

How are you all doing this?

Thanks!

DD

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