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Great. The dosage I use for BPC and TB4 prophylactically is 5-10 mcg per kg biw. I used 5mcg per kg for years and recently switched to 10mcg when my dog had some lameness. That is when I did the PPS protocol. I think 5mcg/kg is probably enough, however, in my case with the lameness, I increased the dosage at least for a while.
Yes. Usually PPS comes 100mg or 125mg/1mL in a 5mL vial. If your dog weighs 8kg, then I would dose (based on the research of 3mg/kg) 24mg qw for 4 weeks. If the vial is 125mg/1mL, then roughly 20 units or 0.20mL per dose. If the vial is 100mg per 1mL, then 25 units or 0.25mL per dose. Hope this helps. Feel free to reach out, if this does not make sense. 702-810-1800
Yes, 3mg/kg sq dosed qw x4 not qid. The dosage is weekly or an interval of 5-7 days. Weekly seems easier.
I have use BPC and TB4 prophylactically on my dog. I have used PPS (Cartrophen vet Rx) as well. The studies show the best dose for OA is 3mg/kg administered in 4x in dogs. The lameness has not returned in my dog.
Hi Miguel! Yes BPC po or sq. The dosage can vary but for general situations: I like 250mcg sq or 500 mcg po 6 days a week at night. For TA-1, I find its greatest benefit as an immune modulator dosage again can vary but for general situations: I like 500mcg 6 days a week morning or night. For oxidative stress, I like NAC, ketone esters KE4, intermittent fasting and exercise.
Hi Lisa! I apologize in advance for the long answer!
The good news is that the SIRT1 gene should be functional. It regulates the FOXO3 which has the dysfunction. Downstream you have likely dysfunctional SOD2 (mitochondria), slightly dysfunctional GPX and functional CAT. SOD is regulated by your likely dysfunctional FOXO3. SOD2 converts the superoxide radical into molecular O2 and H2O2. CAT, primarily, and GPX protect the cell from ROS by converting the H2O2 to water and O2. Since your CAT is likely functional and it is the most important. You should focus on fixing SOD2 with vitamin E (containing alpha, beta, gamma and delta tocopherols) will improve lipid peroxidation in the liver and/or astaxanthin will increase SOD activity. Upregulating PGC-1A also increases SOD2, CAT and GPX1. PGC-1A can be activated by cold, fasting, calorie restriction, reduced carbs, NAC, NAD, Omega 3, butyrate, prebiotic fiber such as guar gum and exercise. Exercise will increase PGC-1A expression 50% – 7-10X following a single bout of exercise. One study showed 2-min of exhaustive exercise corresponds with increased PGC-1A mRNA expression 7-10X, which peaks at around 2 h. Another recently reported 1.5X increases in PGC-1A mRNA levels in men and women after a 16-wk exercise training program consisting of stationary cycling (3–4 sessions/wk at 70–80% maximum heart rate), and another reported increases of 2.7X after 6 wk of running training. Resveratrol will also increase PGC-1A by decreasing its acetylation.
As for peptides, I would work on the inflammation and gut first with BPC-157 oral or sq. I would add what you can from the above list of supplements along with exercise.
Hi Miguel! I think Lisa was using 3×4 Genetics test. I attached a sample report. There are many choices all with plusses and minuses. I developed my own template so I do not have to worry about whether I agree with what these companies say. The biggest problem is there is too much information, many times about things that are not significant. I think SelfDecode’s platform is okay but still too much information. And, in the end, it is the full picture (symptoms, blood work, genetics, etc) that makes the Dx and the Tx. If you have specific cases, I can help.
Hi Lisa! Is your pt homozygous or heterozygous for SOD1/2? It would be helpful to know the pt’s CAT, GPX, GST1 SIRT1 and NQO1 genotype as well. FOXO3 regulates SOD1/2. If you want to share more information, you can send to me (jwcostello@jwcostello.com). Otherwise, my general recommendations are: NAC, low dose Se, Astaxanthin, vitamin C and D and curcumin ( you could try Prodrome curcumin or CurcuWin from Allergy Research Group. Maybe resveratrol.
Hi Patrick
I use phase angle for measuring cell regeneration. I never thought of it for senescence. I suppose a good phase angle would be indicative of less senescence. I think from what I have seen in my practice, this makes sense to use a general marker. However, I still thing the gold standard may be the SABG test.
Jamie
Hi Leonard
Here is an article discussing weekly and daily dosing for the GLP-1 agonists. I think this will be helpful in setting the appropriate protocol.
Divino V, Boye KS, Lebrec J, DeKoven M & Norrbacka K. (2019). GLP-1 RA Treatment and Dosing Patterns among type 2 diabetes patients in six countries: a retrospective analysis of Pharmacy claims data. Diabetes Ther. 10:1067-1088. DOI: 10.1007/s13300-019-0615-5
Hi Patrick! I have been using SA-B-Gal for some time to measure senescence. I think it is effective but not cheap. I have been using the Aging SOS test which include intra and extracellular NAD. It would be nice to have a standard protocol that we all use and get a discount. The bulk of the Aging SOS test is too expensive when I truly only want the NAD and SA-B-Gal. Jamie
Hi Siobhan, I use 150mg at night for calming/sleep or as part of an injury recovery protocol. Suntheanine is the branded product in several supplements. I just recommend the Bulk Supplement L-Theanine available on Amazon.
