Podcast Library

Kelli Musa returns to unpack her Self-Led Woman framework, mapping how hormonal, metabolic, neurological, and cellular systems collide during perimenopause and menopause. Dr. Seeds ties the discussion to mitochondrial biogenesis and cellular decision-making, while the group explores GLP-1s, BPC-157, and TB-500 for weight, inflammation, and tissue repair.

Functional wellness practitioner Kelli Musa joins the show to challenge how mainstream medicine handles women's hormonal health. The conversation revisits the misread 2002 hormone study, the difference between normal and optimal hormone levels, and how cortisol, estrogen, and progesterone work as an interconnected system through perimenopause and beyond.

Recorded live at Peptide World Congress 2026, Dr. William Seeds makes the case against symptom-based medicine and walks through how cells actually make decisions: sensing redox balance, allocating energy through AMPK and mTOR, activating NRF2 antioxidant defenses, and protecting mitochondrial DNA. A phenotype-guided framework for cellular optimization.

Dr. Seeds reframes modern care around phenotyping rather than treating symptoms or diagnoses, explaining why peptides work as signaling molecules that help cells make better decisions. Matt and Maddie also preview the Peptide World Congress and the launch of a graduate-level cellular medicine course.

The FDA has announced safety and efficacy reviews of roughly a dozen compounded peptides, including BPC-157, TB-500, DSIP and Melanotan 2, moving several off the restricted category 2 list. Dr. Seeds unpacks the PCAC review process, API manufacturing standards, and why preclinical mechanisms still need human clinical evidence.

Dr. Seeds separates stretching fact from gym-floor fallacy, explaining why static holds before training can backfire while dynamic mobility work prepares the body. He digs into the molecular payoff of stretching done correctly, from inhibiting myostatin and boosting follistatin to adding sarcomeres in series for better contraction velocity.

Dr. Seeds walks Matt and Maddie through the nine B vitamins, from thiamine and riboflavin to folate and B12, explaining absorption pitfalls, over-fortification, and toxicity risks. The conversation digs into homocysteine, one-carbon metabolism, and the MTHFR gene variants that shape methylation and neurotransmitter production.

Magnesium comes in many forms, and this discussion breaks down how glycinate, citrate, threonate, and others carry the mineral to different tissues. Matt and Dr. Seeds cover why soil depletion and poor diets leave many people short, how magnesium moves into cells and mitochondria, and when true repletion matters.

Matt, Maddie, and Dr. Seeds unpack why rapid weight loss on GLP-1 medications can leave the face looking sunken and prematurely aged. The real driver is collagen and elastin failing to keep pace with fat compartment loss, compounded by declining estrogen and mitochondrial inefficiency in women near menopause.

Is hair loss truly genetic? Dr. Seeds breaks down the four types of alopecia and why the follicle's own ecosystem, DHT sensitivity, mitochondrial energy, and scalp fibrosis matter more than a single gene. The talk covers biotin's real role plus regenerative options like microneedling, PRP, and GHK-Cu.

Skin aging splits into intrinsic mitochondrial decline and extrinsic damage, with UV light driving roughly 80 percent of visible changes. Dr. Seeds explains UVA versus UVB, the mitochondrial DNA 4977 deletion behind photoaging, Asian PA sunscreen ratings, vitamin D synthesis, and how the peptide Melanotan stimulates protective melanin.

Urolithin A, a postbiotic your gut makes from pomegranate, walnuts and berries, takes center stage in this look at mitophagy and mitochondrial renewal. Dr. Seeds reviews human trials showing improved oxidative phosphorylation in immune cells, why roughly 40 percent of people cannot produce it naturally, and its role in supporting vaccination response as we age.

Facial plastic surgeon Keith Marcus and nurse Kristen Nagarian share how they folded cellular medicine into their aesthetic practice after joining the SSRP. The conversation traces their path from clinical research and surgery toward a root-cause approach, reframing aesthetics as work that happens from the inside out.

Drawing on decades as an orthopedic and sports medicine surgeon, Dr. Seeds reframes recovery from sports injuries around cellular mechanisms rather than wear and tear. The episode explores tendon and muscle repair, TGF-beta signaling, cartilage degeneration, overtraining, sarcopenia, and the load adaptation that keeps joints resilient with age.

Ubiquinol, the reduced form of CoQ10, gets a careful reassessment as a mitochondrial electron carrier. Dr. Seeds explains its genuine value for people on statins, which block CoQ10 synthesis, while pushing back on marketing that frames it as a universal energy or longevity supplement for already-healthy individuals.

Can you teach an old brain new tricks? Dr. Seeds distinguishes neurogenesis from the synaptic plasticity that actually keeps the brain adaptable, tracing the glutamate-to-BDNF cascade. Exercise, sleep and glymphatic drainage, nutrition, novelty, and social connection all emerge as levers for lasting cognitive resilience.

Coffee acts less as fuel and more as a neuromodulator. Dr. Seeds breaks down how caffeine blocks adenosine A1 and A2A receptors to boost dopamine, acetylcholine and alertness, why it can mask HPA-axis dysregulation in stressed bodies, and what chlorogenic acids and polyphenols mean for gut and metabolic health.

Guest Damian Hancock, CEO of Spectrum X, joins to discuss a drug-grade NAD+ formulation delivered through a single-use injection pen modeled on GLP-1 devices. The conversation centers on manufacturing quality, endotoxin and sterility concerns with compounded NAD, and why standardized dosing gives prescribers a reliable baseline.

A New York Times report on gray-market Chinese peptides flooding Silicon Valley frames this discussion of sourcing, safety, and FDA oversight. Dr. Seeds contrasts 503A compounded peptides under physician supervision with unregulated research chemicals, and pushes back on reckless claims like nasal oxytocin being Ozempic for autism.

As AI tools like ChatGPT move into clinics and prescription renewals, Dr. Seeds weighs their real limits against the hype. He argues pattern-matching software cannot interpret changing patient biology or replace mechanistic reasoning, while acknowledging AI can help synthesize histories and structure data when used as a support tool.

Alzheimer's gets reframed as a phenotype rather than a single plaque disease. The discussion breaks down five converging drivers: amyloid and tau from lost proteostasis, microglial neuroinflammation, mitochondrial energy failure, vascular dysfunction, and insulin resistance, all tracing back to oxidative stress in the neuron over decades.

The gut and brain talk constantly. Dr. Seeds walks through how barrier breakdown, low-grade immune activation, and vagus-nerve signaling connect a struggling microbiome to neurodegeneration. Short-chain fatty acids like butyrate, dietary fiber, and metabolite signaling take center stage over simplistic good-versus-bad bug thinking.

Fresh off a review paper published in JAAOS Global Research and Reviews with co-authors Dr. Omar Raman and Dr. Stephen Lee, Dr. Seeds discusses therapeutic peptides in orthopedics. The conversation covers wound-healing agents like BPC-157 and GHK-Cu, growth hormone secretagogues, and the need for rigorous clinical trials.

A single 81 mg aspirin does far more than thin blood. Dr. Seeds explains how acetylation shuts down COX-1 while retasking COX-2 to produce pro-resolving mediators like resolvins and lipoxins from omega-3s, plus its effects on the cGAS-STING pathway, PPAR alpha and the resolution of chronic inflammation, along with who should avoid it.