EVENT
Mastermind
Four Seasons Resort Oahu at Ko Olina

Mastermind 15 - The Aesthetic Matrix

Four Seasons Resort Oahu at Ko Olina
March 13–15, 2026

Cellular Medicine Mastermind

The Aesthetic Matrix

Event gallery
Event gallery

MASTER THE LATEST CELLULAR MEDICINE THERAPIES YIELDING TRANSFORMATIVE AESTHETIC RESULTS

The future of aesthetics extends beyond superficial skin treatments. Mastermind 15 presents Cellular Medicine as an emerging science-based approach for creating true skin and body rejuvenation from within. The cellular engines that produce authentic aesthetic results (including mitochondrial health, redox signaling, and regenerative immune responses) will provide practitioners with a strong new framework to enhance their results and increase patient satisfaction while aging gracefully.

You will learn how to utilize biological processes to restore fibroblast, melanocyte, and keratinocyte function, enhance skin texture and tone internally, reverse hair loss at the follicular level, and reshape the body through metabolic signaling (instead of devices). You’ll learn to implement advanced protocols with peptides, exosomes, stem cells, and redox therapies to deliver deep and enduring results.

SPEAKERS

Speaker List

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William Seeds, MD

Mastermind 15 - The Aesthetic Matrix Schedule

Venue Title Speakers Time
Ko Olina, Oahu Hawaii THE BIOLOGY OF BEAUTY
Mitochondria, Redox Signaling, and the Foundations of Skin Health.
  • The origin of aging cells from cellular energy consumption and redox balance.
  • The role of ROS in regeneration has been widely misunderstood in scientific literature.
  • Sirtuins activate mitochondrial signals while NAD⁺ acts as a signaling molecule for dermal layers.
  • The Cellular Medicine perspective presents a new perspective on oxidative stress.
William Seeds, MD
William Seeds, MD
 8:00 AM - 10:00 AM
Ko Olina, Oahu Hawaii AESTHETIC CELL ATLAS
Fibroblasts, Melanocytes, Keratinocytes, and Immune Crosstalk
  • The process of collagen remodeling and bioenergetics depends on fibroblasts.
  • The melanocyte regulatory system functions as a pigment optimization mechanism.
  • Keratinocytes perform barrier renewal and inflammatory signaling through their turnover process.
  • The immune system consists of mast cells and Langerhans cells that work with chronic aesthetic inflammation.
William Seeds, MD
William Seeds, MD
 10:30 AM - 12:30 PM
Ko Olina, Oahu Hawaii REJUVENATION PATHWAYS
The Skin's Regulatory Network consists of AMPK, mTOR, FOXO, NRF2 and various other signaling pathways.
  • The energy sensors along with protein turnover regulators function as the main control mechanisms.
  • Autophagy and mitophagy enable the skin and hair to achieve optimal health.
  • The NRF2–KEAP1 axis operates as a defense mechanism against UV light and an antioxidant response system.
  • The pathogenesis of aging occurs due to imbalanced pathways which health care providers fail to understand in their upstream mechanisms.
William Seeds, MD
William Seeds, MD
 1:30 PM - 3:30 PM
Ko Olina, Oahu Hawaii EXTERNAL EXPRESSION
Gut, Hormones and Metabolic Dysregulation create skin and hair effects.
  • Estrogen and testosterone along with thyroid hormones and cortisol serve as hormonal signals that affect the body.
  • The gut–skin–immune axis functions as a system which combines endotoxins with microbiota to create skin reactivity.
  • The combination of insulin resistance with glycation creates dermal inflammation.
  • The skin shows signs of mitochondrial adaptation during systemic illness.
William Seeds, MD
William Seeds, MD
 4:00 PM - 6:00 PM
Venue Title Speakers Time
Ko Olina, Oahu Hawaii REGENERATIVE TOOLKIT
Peptides, Exosomes, Stem Cells and Future-Ready Biologics
  • GHK-Cu, BPC-157, TB-4, Epitalon & more ,mechanisms together with their clinical applications.
  • Exosomes , stem cells and mitochondrial EVs and their roles in skin healing processes.
  • Future biologic innovations through Klotho and FOXO modulators and SIRT activators.
  • The differences between systemic and local intervention strategies.
William Seeds, MD
William Seeds, MD
 8:00 AM - 10:00 AM
Ko Olina, Oahu Hawaii HAIR REGENERATION
The Follicle as a Metabolic Sensor
  • How HFSCs manage their mitochondria during hair growth cycles.
  • How prostaglandins together with androgens and inflammatory mediators affect the body.
  • Cellular disruptions in alopecia by identifying root causes and describing reprogramming strategies.
  • How to combine peptides with redox and hormones in treatment protocols.
William Seeds, MD
William Seeds, MD
 10:30 AM - 12:30 PM
Ko Olina, Oahu Hawaii WHOLE-BODY INTEGRATION
Fat, Muscle, Skin, Fascia, and the Lymphatic Interface
  • The bioenergetic processes that occur during fat remodeling and browning.
  • Muscle tone functions as an aesthetic signal through myokines.
  • Skin elasticity and fascia as structural elements that people tend to overlook.
  • Mitochondrial drainage functions through lymphatic flow to create both tone and clarity.
William Seeds, MD
William Seeds, MD
 1:30 PM - 3:30 PM
Ko Olina, Oahu Hawaii Clinical Care
Case Studies, Systems-Based Assessment, and Implementation
  • Clinical phenotype mapping and upstream targeting
  • Patient stratification and outcome-driven protocol design
  • The walkthroughs of cases include aging face, melasma, post-procedure, acne
  • Redox, peptides, hormones, and metabolic restoration are integrated in the treatment.
William Seeds, MD
William Seeds, MD
 4:00 PM - 6:00 PM
Venue Title Speakers Time
Ko Olina, Oahu Hawaii Overflow
Additional time scheduled for audience questions, deep dives, and remaining material from previous days.
William Seeds, MD
William Seeds, MD
 8:00 AM - 12:00 PM

*agenda subject to change

VENUE

FOUR SEASONS OAHU RESORT AT KO OLINA

HOSTED AT THE FOUR SEASONS OAHU RESORT AT KO OLINA IN OAHU, HAWAII

Oʻahu is a breathtaking tropical paradise known as “The Gathering Place,” where jagged green cliffs meet sparkling turquoise waters across diverse landscapes—from the legendary surf of the North Shore to the serene sands of Lanikai Beach and lush valleys like Kualoa Ranch. It’s a vibrant mix of urban energy in Honolulu and peaceful natural retreats, offering unforgettable hikes, cultural landmarks, and iconic island scenery.

Nestled on Oʻahu’s sun-kissed leeward coast in Ko Olina, the Four Seasons Resort Oʻahu offers an elegant beachfront retreat with panoramic ocean vistas, infinity pools, lagoons, lush gardens, a luxury spa, and tennis and fitness facilities. Guests enjoy access to water sports, a championship golf course, multiple dining venues, and spacious, refined accommodations—creating a harmonious blend of adventure and relaxation in a prime island setting.

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Four Seasons Resort Oahu at Ko Olina

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Start your Cellular Medicine journey with our Founder and Academic Chairman, Dr. William Seeds, and build a strong foundation in a cellular-level approach to patient care.

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COURSE
Foundations Foundations
1 hrs 46 min
Cellular Medicine Foundations
Foundations Foundations
Cellular Medicine Foundations
This course introduces a cellular medicine framework for understanding how cells make energy and adapt to stress through changes in metabolism, mitochondrial function, redox balance, and signaling that influences gene expression. Across six lessons, you will examine how common stressors...
6 Lessons
1 hrs 46 min
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