I have encountered this issue in patients who received the COVID-19 vaccine or have long-haul COVID-19: some will present with full-on P.O.T.S. Some might have a mild like P.O.T.S.
TB4:
Neural Regeneration and Aberrant Nerve Repair: TB4 promotes nerve repair by facilitating actin polymerization, axon regeneration, and Schwann cell migration.
•It also increases growth factors like Fibroblast Growth Factor (FGF-2) and Vascular Endothelial Growth Factor (VEGF), which support neural and vascular regrowth.
*A)
If autonomic nerves (sympathetic or parasympathetic) are regenerated improperly or excessively, it could lead to:
•Sympathetic hyperactivity: Overactivity in repaired sympathetic fibers (e.g., tachycardia, hypertension).
•Parasympathetic dysfunction: Impaired parasympathetic signaling (e.g., gastroparesis, hypotension).
•Example: This mechanism is similar to what is observed in some cases of Complex Regional Pain Syndrome (CRPS), where nerve repair leads to disorganized autonomic function.
B)Prolonged or excessive immune modulation could inadvertently affect the autonomic control centers, such as the hypothalamus or vagus nerve.
TB4 drives angiogenesis via VEGF and promotes vascular repair.
C)
Potential Dysautonomia Pathway:
•Abnormal angiogenesis or misdirected vascular-nerve regrowth could result in:
•Impaired autonomic control of blood flow (e.g., orthostatic intolerance, Raynaud ’s-like symptoms).
•Hyperinnervation of blood vessels, leading to overactive vasoconstriction (e.g., hypertension or excessive sweating).
D)
•Overactivation of the PI3K-Akt pathway: prolonged activation beyond normal physiological levels. This can result from:
•Mutations in pathway components (e.g., PI3K, PTEN, or Akt).
•Chronic stimulation by external signals (e.g., growth factors, drugs).
•Disruption of harmful feedback mechanisms (e.g., loss of PTEN function).
Our office has now transformed into treating COVID-19 vaccine injuries. Unfortunately, they come from all over because physicians are either not connecting or in denial. We are also seeing “Turbo Cancer” from the jab. Dr. William Makis (Substack), a Canadian conventional oncologist before COVID-19, is now waking up to the fact that cancer is a metabolic disease starting with the Mitochondria. A prominent oncologist is now treating cancer by unlocking the Warburg effect.
Consequences of PI3K-Akt Pathway Overactivation
1. Cancer
•Mechanism:
•Overactivation promotes uncontrolled cell growth and survival, bypassing apoptosis.
•Increased angiogenesis and metabolic reprogramming support tumor progression.
•Examples:
•Common in cancers such as breast, prostate, ovarian, and glioblastoma.
2. Autonomic Nervous System Effects
•Mechanism:
•Excessive nerve repair or regrowth due to enhanced Akt activation could lead to hyperregeneration or miswiring of autonomic nerves.
•Disruption of homeostatic signaling may result in autonomic dysfunction (e.g., dysautonomia).
•Outcome: This may manifest as sympathetic hyperactivity (e.g., hypertension) or parasympathetic dysfunction (e.g., gastroparesis).
