Tesamorelin dosage

[Linda Kiley]

I have a manufacturer in the US who is producing peptides (not a pharmacy, an FDA approved/inspected lab), producing a Tesamorelin/Ipamorelin product that when reconstituted would give a dosage of 0.125/0.125 mcg Tesa/Ipa.  I can find nothing on such a small dosage of tesamorelin.  I am skeptical of this regimen (first of all, where does that dosage come from?).  Does anyone have any experience with “microdosing” tesamorelin? Does it even make sense? The lowest dosage I have found from the peptide course was 1mg. I found one practitioner who was using 500mcg instead of 1mg with some success, but that is still a lot more than 125mcg.

Thanks!

[Kristelle Reyes]

Hello @byurthgmail-com, @drhusaininterlinkedmd-com, @leonard-pastranagmail-com, @drkriswyahoo-com, @andkeller2gmail-com, @dr-siobhannewmangmail-com, and @cpaigepaigemd-com, we would love to have your insights here. Thank you!

[Abid Husain]

Hi Linda,

 

I use these dose regularly on my patients.  The doses studied for tesamorelin are much higher at 1mg but that can cause side effects associated with elevated GH ( edema, carpel tunnel, myalgias, joint pain).  In that population, is makes sense to start low and tirate up of desired.   CJC1259, a similar GHRH, is used at low doses ( 100mcg).  I will often start at 125 or 250mcg and keep them there for cost effectiveness and to minimize side effects, especially in elderly or fragile patients.

This is entirely anecdotal experience.  Although there aren’t any studies validating Tesa’s use in low doses, I believe it still has some utility.

On a side note, I advise against using anything that is not a pharmacy approved for anything but human use.

Hope this helps,

Abid

[Kristelle Reyes]

Thank you for that great insight, Dr. Husain!

@lkileymdgmail-com, here’s a video response from Dr. Seeds’ Office Hours – June 2024 at 15:47. Please watch by clicking the link below:

https://ssrpinstitute.org/ssrp-members-videos/

Thank you! 🙂

[Jennifer Broad]

Dr Husain

Do you do any specific testing when administering with GHRH (ie Ipa or Tesa) for a baseline and to follow up with? Anything that can show effectiveness or adverse effects? Other than the clinical symptoms as you mentioned (carpel tunnel, myalgia joint pain etc)

thank you

[Abid Husain]

Hi Jennifer,

I don’t do any specific testing prior to starting GHRH/GHRPs.  I do take a thorough history making sure to identify any malignancy or autoimmune diseases.

Although the data on malignancy and secretogauges may indicate safety, you would be accused of malpractice by oncologists and other doctors by prescribing them in the presence of any tumor.  Best to screen for malignancy and steer clear of that problem.

Autoimmune conditions would benefit from low intensity test dosing and slow titration up.  Starting at regular dosing can trigger an autoimmune flare in a fragile patient so it is important to be aware of that in the history.  I would consider ipa 100mcg alone or  “microdose” of 125mcg tesa as the test cycle before scaling up.

Some practitioners check IGF-1 levels at baseline and treatment.  IGF-1 levels can be a gauge of GH levels but there are many other contributing factors to IGF-1 so it may not be accurate.  And IGF-1 wont often increase until you push tesa doses to the upper ranges at 500mcg-1000mcg daily, though individual responses will vary.

hope this helps,

Abid

[Kristelle Reyes]

Thank you so much, @drhusaininterlinkedmd-com! 🙂

Hello @lkileymdgmail-com and @jbroad1121gmail-com,

Here’s a video response from Dr. Seeds’ August Office Hours at 00:54. Please watch by clicking the link below:

https://ssrpinstitute.org/ssrp-members-videos/

Thank you! 🙂

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