Articles Library
Research-informed articles from SSRP Fellows and guest authors—connecting cellular mechanisms to real-world clinical application.
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William Seeds, MD
Jan 20, 2026
Microglia
Microglia are the brain’s resident immune cells — but they’re much more than just defenders. Think of them as a combination of janitors, gardeners, and neighborhood watch patrols that keep the brain healthy, balanced, and adaptable. The Brain’s First Responders Microglia constantly patrol the brain, extending and retracting their tiny branches like radar antennas. When […]
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William Seeds, MD
Dec 17, 2025
The Brain and Exercise: How Different Forms of Exercise Impact Neuronal Metabolism and Neuroprotection
Introduction Understanding brain metabolism offers insight not only into the potential root causes of neurodegenerative disease but also the interventions that can positively impact cognitive functioning. In particular, looking at the pathways, energy use, and factors of neuronal adaptation that happens in exercise offers us important insight into the basis of neuroprotection. Let’s keep in […]
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William Seeds, MD
Nov 12, 2025
Improving Biological Age with GLP-1 RAs: An Analysis of a Study
This is a further dive into and expansion of a Journal Club video that I offered in September 2025 in response to a fascinating article related to the power of GLP-1 peptides to create positive epigenetic changes at the cellular level. The study, Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized […]
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William Seeds, MD
Oct 8, 2025
A New Medical Paradigm That Redefines Aging
Western medicine’s reliance on drugs and intervention procedures to treat symptoms of disease. This dependence stems from an antiquated way of thinking about and applying medical advances, one that overlooks an enormous opportunity to avoid disease, preserve health, and extend a high quality of life. Indeed, most scientists and medical doctors still think of aging […]
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William Seeds, MD
Sep 10, 2025
Getting to Know GLP-1 Peptides
There’s been a lot of hype about GLP-1 peptides over the past few years due to their measurable success at helping people lose significant weight and reduce the biomarkers related to type-2 diabetes. This blog is a sneak peek from my new book, The Quantum Power of GLP-1 Peptides. The body naturally produces glucagon-like peptides, which […]
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William Seeds, MD
Aug 8, 2025
The Benefits and Implications of Butyrate
Benefits of Butyrate I must admit that I love butyrate, which is why I recommended it as an important over-the-counter supplement in The Redox Promise....
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William Seeds, MD
Jul 2, 2025
Understanding Circadian Clock Disruption
This is part two of a series on optimizing sleep. If you haven't already ready Sleep Basics, you can check it out in the Articles...
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William Seeds, MD
Jun 25, 2025
Sleep Basics
How well we sleep—in terms of both duration and quality—plays a vital role in how well our brain and body functions. Sleep enables the brain...
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William Seeds, MD
May 2, 2025
Four Supplements to Improve the Gut
These 4 supplements support overall cellular health and enhance your healthspan by supporting the gut microbiome. Each works on a specific attribute of cell functioning—enhancing...
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William Seeds, MD
Apr 29, 2025
Maximizing Healthspan Through Cellular Adaptation
The Yin and Yang of Homeostasis As you may recall, homeostasis is a word we use in biology, molecular biology, and cellular medicine to describe...
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William Seeds, MD
Feb 28, 2025
The Mighty Mitochondria
You have probably heard that mitochondria are called the “powerhouse of the cell” and yes, that’s true! These organelles produce ATP, which is the main...
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