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Veterinary epidemiologist Dr. Stephanie Venn-Watson recounts how studying Navy dolphins uncovered C15, or pentadecanoic acid, the first essential fatty acid identified in over 90 years. She and Dr. Seeds explore cellular fragility syndrome, how C15 strengthens cell membranes, and its roles in signaling, metabolism, and epigenetic regulation.
Beyond Energy: How Mitochondria Adapt to Life
This month on Rabbit Holes, Dr. Seeds challenges the reductionist view of mitochondria as “the powerhouse of the cell.” He takes us deep into how mitochondria regulate energy, metabolism, morphology, and redox — and why their ability to adapt is at the core of preventing dysfunction, disease, and decline.
Whether you’re working with clients, patients, or protocols, this episode will give you the context needed to understand cellular adaptation and its real-life clinical relevance.
Methylene blue gets scrutinized as a redox-cycling agent that shuttles electrons past damaged complexes in the electron transport chain. Dr. Seeds defends its role in specific disease states while warning that its inhibition of nitric oxide and blocking of mitochondrial adaptation make it a poor choice for healthy people chasing performance.
Is TA1 Underdosed in Sepsis?
In this episode, Dr. Seeds breaks down a recent clinical trial on Thymosin Alpha-1 in sepsis, weighing its results against real-world application. Learn why dosing, biomarkers, and peptide combinations like TB4 matter more than ever.
NAD gets a hard look as Dr. Seeds challenges the booming infusion industry. He explains NAD's real role as a redox cofactor and sirtuin substrate, why CD38 sinks and senescent cells grab it first, and why the energy rush people feel is a false, catecholamine-driven signal rather than new ATP.
Can Walnuts Boost Brain Power?
Dr. Seeds reviews a study on how a walnut-rich breakfast affects cognition and mood in healthy adults.
The episode explores glucose metabolism, brain performance, and the potential of food as a clinical tool. (Article Link)
Is metformin really an anti-aging drug? Dr. Seeds pushes back on the longevity hype, noting the diabetes medication inhibits mitochondrial complex I, the very electron-transport machinery cellular medicine aims to strengthen. He examines the Horvath clock and telomere claims, and studies showing its mortality benefits may be short-lived.
Omega-3 vs Omega-6: What Really Matters
In this episode of Rabbit Holes, Dr. Seeds unpacks the delicate balance between pro- and anti-inflammatory fats, breaking down how omega-3 and omega-6 fatty acids impact your health—from immune response to chronic inflammation.
In this third book, Dr. Seeds offers readers a concise guide to both the research and clinical applications of GLP-1s and other peptides. This book is intended to empower medical professionals and individuals who want to be part of a healthcare movement committed not only to longevity but to optimal healthspan.
Fiber is framed as the trigger for a cascade of molecular pathways rather than just a digestive aid. Dr. Seeds explains how gut microbes ferment indigestible fiber into short-chain fatty acids like butyrate, propionate and acetate that fuel colon cells, stimulate the body's own GLP-1 release, and support microbiome diversity and lipid metabolism.
Jason DiBona, CEO of Molekule, joins to examine how airborne pollutants damage health at the cellular level. The talk covers PM2.5 particulates crossing the lung barrier, oxidative stress and mitochondrial dysfunction, inflammaging, and why indoor air can be far dirtier than outdoor, making clean air a foundational part of any wellness routine.
From Concept to Clinical Strategy
In this episode, Dr. Seeds evaluates a detailed, phase-based plan submitted by an SSRP member—highlighting where to start, how to sequence, and why clarity matters in cellular-focused protocols.
Insightful, practical, and packed with takeaways for your own clinical journey.
Continuing the aesthetics conversation, Dr. Seeds explains what Botox actually does at the cellular level. Beyond legitimate uses for spasticity and migraines, cosmetic injections paralyze facial muscle, and the resulting disuse can drive atrophy, senescent cells, and fibrous tissue that complicate collagen health and later plastic surgery.
Circadian Clocks & Cellular Consequences
In this Journal Club episode, Dr. Seeds explores how early school schedules disrupt natural rhythms—and what that means for mitochondrial health, gene expression, and recovery.
A must-watch for understanding why time is a molecule in cellular medicine. (Article Link)
The extracellular matrix takes the spotlight as Dr. Seeds explains how BPC-157 and TB-500 support recovery, repair, and injury prevention at the cellular level. The episode also covers why static stretching before training can set you up for injury and makes the case for active, dynamic warmups.
Methylation, Muscle & the Epigenome
Explore how epigenetic shifts—like DNA methylation and histone acetylation—link exercise to improved gene expression, redox balance, and cellular resilience. A foundational discussion in the cellular medicine model.
Listener questions drive this AMA, opening with how people in their 30s can protect the cellular efficiency that begins declining with age. Dr. Seeds returns repeatedly to exercise as the master lever for sleep, mood, and metabolism, then unpacks calorie restriction, the four-day fast, and pairing secretagogue peptides with fasting.