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Fasting, Food & Peptides
In this episode, Dr. Seeds answers a common question: Do peptides need to be taken on an empty stomach? He explains why growth hormone secretagogues like CJC/Ipamorelin are best taken fasted, why oral BPC and KPV stand out, and how carbs, fats, and insulin impact growth hormone pulses. With practical guidance on timing and a clear look at the science, this episode offers members the clarity they need to optimize peptide use.
Creatine gets demystified as far more than a bodybuilding staple. Dr. Seeds frames it as an on-demand ATP battery built through phosphocreatine in the mitochondria, then explores its reach into brain energy, glutamate recycling, anxiety, and methylation. The team also untangles the creatine versus creatinine confusion.
Can one year of heavy lifting change the course of aging?
Dr. Seeds unpacks the groundbreaking LISA Study, which tracked older adults over four years after just one year of resistance training. The results? Remarkable strength preservation, visceral fat control, and evidence of long-term neuromuscular adaptation—especially in women.
Explore why strength—not just muscle mass—matters for health span, and how these findings reinforce the cellular medicine approach to aging, recovery, and metabolic resilience. (Article Link)
Emergency medicine physician and SSRP faculty member Dr. Siobhan Newman shares how frustration with reactive care drew her toward cellular medicine. She discusses personalizing treatment for complex neurodegenerative and autoimmune cases, why the word longevity can ring hollow, and how family and community anchor lasting health outcomes.
Resistance is Vital: Training for Healthspan
Dr. Seeds unpacks why resistance training is one of the most effective tools for preserving muscle, improving mitochondrial function, and extending health span—especially in older adults. He connects key cellular pathways like AMPK, mTOR, and PGC-1α to real-world outcomes like strength retention, metabolic flexibility, and reduced inflammation. With new long-term data from the LESA study, this episode offers essential insight for anyone focused on aging well through the lens of cellular medicine.
A deep look at estrogen, progesterone, and testosterone across a woman's life and their roles in mitochondrial function, cognition, bone, and tissue repair. Dr. Seeds emphasizes mapping estrogen metabolites through urine testing before prescribing hormones and revisits the flawed 2002 Women's Health Initiative study that set HRT back for decades.
- Exploring metformin for muscle health vs impared mitochondrial function and blunt adaptation to exercise? [01:15]
- Chronic Bartonella symptoms using a cellular approach before antibiotics? [17:04]
- OS-1 peptide for hair growth? [36:21]
Low testosterone is rarely solved by simply handing a man testosterone. Dr. Seeds and Maddie examine hypogonadism as a cellular problem, where membrane fluidity, mitochondrial NADPH, cholesterol transport, and androgen-receptor density govern production. They also revisit the flawed studies behind the FDA's since-removed cardiovascular warning on testosterone therapy.
Incorporating MOTS-c with NAD
Dr. Seeds breaks down the molecular strategies behind improving metabolic flexibility using MOTS-c and a deeper understanding of NAD salvage pathways. Learn why substrate switching is key for energy efficiency, and how precise interventions—like small molecule NNMT inhibitors—can reshape redox balance and mitochondrial resilience. Whether you’re treating aging, fatigue, insulin resistance, or mitochondrial dysfunction, this is essential education for anyone interested in precision cellular medicine.
Part three of Dr. Seeds' story traces his path from a demanding New York surgical residency during the AIDS crisis through a foot and ankle fellowship he ultimately declined. He recounts building Seeds Orthopedics and quietly treating elite athletes at an Olympic training center using peptides, stem cells and tissue-repair protocols.
Methylene Blue and Misconceptions
This month, Dr. Seeds explores a recent study examining methylene blue’s acute effects on the brain in healthy individuals. He breaks down the cellular mechanisms at play—including oxidative phosphorylation, nitric oxide inhibition, and dose-dependent effects on brain metabolism—and explains why this popular “longevity” compound may be doing more harm than good outside of clinical contexts. (Article Link)
In the second part of his personal case study, Dr. Seeds shares the experiences that shaped him, from a childhood lesson in integrity at a hardware store to his early plans for a life on the ski slopes. He recounts losing his father suddenly at seventeen and the vow that redirected him toward medicine.
The Telomere Trap
This month on Rabbit Holes, Dr. Seeds challenges one of the most widely misunderstood topics in the longevity space: telomeres.
Are longer telomeres really the key to living longer? Or is the real driver of health span hidden in mitochondrial resilience, redox balance, and functional cell integrity?
In this eye-opening episode, Dr. Seeds explores the difference between replicative vs. functional senescence, revealing why the telomere hype may be missing the bigger picture in post-mitotic cells like neurons, heart, and skeletal muscle.
Dr. Seeds opens up about his family tree in part one of a personal case study. He recounts his grandfather Elmore, a pioneer of nuclear medicine, and his father Asa, who helped establish maternal-fetal medicine, plus the habit of questioning everything that shaped his path into cellular medicine.
- Should bodybuilders use collagen? Research-backed guidance on its role in training and tissue repair. [0:38]
- Mitochondrial myopathy, Hashimoto’s, and asthma in a 64 y/o female—how to improve strength and respiratory resilience. [11:23]
- Post-liver lobectomy with PCOS and poor sleep; peptide suggestions. [22:32]
Veterinary epidemiologist Dr. Stephanie Venn-Watson recounts how studying Navy dolphins uncovered C15, or pentadecanoic acid, the first essential fatty acid identified in over 90 years. She and Dr. Seeds explore cellular fragility syndrome, how C15 strengthens cell membranes, and its roles in signaling, metabolism, and epigenetic regulation.
Beyond Energy: How Mitochondria Adapt to Life
This month on Rabbit Holes, Dr. Seeds challenges the reductionist view of mitochondria as “the powerhouse of the cell.” He takes us deep into how mitochondria regulate energy, metabolism, morphology, and redox — and why their ability to adapt is at the core of preventing dysfunction, disease, and decline.
Whether you’re working with clients, patients, or protocols, this episode will give you the context needed to understand cellular adaptation and its real-life clinical relevance.
Methylene blue gets scrutinized as a redox-cycling agent that shuttles electrons past damaged complexes in the electron transport chain. Dr. Seeds defends its role in specific disease states while warning that its inhibition of nitric oxide and blocking of mitochondrial adaptation make it a poor choice for healthy people chasing performance.