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A deep look at estrogen, progesterone, and testosterone across a woman's life and their roles in mitochondrial function, cognition, bone, and tissue repair. Dr. Seeds emphasizes mapping estrogen metabolites through urine testing before prescribing hormones and revisits the flawed 2002 Women's Health Initiative study that set HRT back for decades.
- Exploring metformin for muscle health vs impared mitochondrial function and blunt adaptation to exercise? [01:15]
- Chronic Bartonella symptoms using a cellular approach before antibiotics? [17:04]
- OS-1 peptide for hair growth? [36:21]
Low testosterone is rarely solved by simply handing a man testosterone. Dr. Seeds and Maddie examine hypogonadism as a cellular problem, where membrane fluidity, mitochondrial NADPH, cholesterol transport, and androgen-receptor density govern production. They also revisit the flawed studies behind the FDA's since-removed cardiovascular warning on testosterone therapy.
Incorporating MOTS-c with NAD
Dr. Seeds breaks down the molecular strategies behind improving metabolic flexibility using MOTS-c and a deeper understanding of NAD salvage pathways. Learn why substrate switching is key for energy efficiency, and how precise interventions—like small molecule NNMT inhibitors—can reshape redox balance and mitochondrial resilience. Whether you’re treating aging, fatigue, insulin resistance, or mitochondrial dysfunction, this is essential education for anyone interested in precision cellular medicine.
Part three of Dr. Seeds' story traces his path from a demanding New York surgical residency during the AIDS crisis through a foot and ankle fellowship he ultimately declined. He recounts building Seeds Orthopedics and quietly treating elite athletes at an Olympic training center using peptides, stem cells and tissue-repair protocols.
Methylene Blue and Misconceptions
This month, Dr. Seeds explores a recent study examining methylene blue’s acute effects on the brain in healthy individuals. He breaks down the cellular mechanisms at play—including oxidative phosphorylation, nitric oxide inhibition, and dose-dependent effects on brain metabolism—and explains why this popular “longevity” compound may be doing more harm than good outside of clinical contexts. (Article Link)
In the second part of his personal case study, Dr. Seeds shares the experiences that shaped him, from a childhood lesson in integrity at a hardware store to his early plans for a life on the ski slopes. He recounts losing his father suddenly at seventeen and the vow that redirected him toward medicine.
The Telomere Trap
This month on Rabbit Holes, Dr. Seeds challenges one of the most widely misunderstood topics in the longevity space: telomeres.
Are longer telomeres really the key to living longer? Or is the real driver of health span hidden in mitochondrial resilience, redox balance, and functional cell integrity?
In this eye-opening episode, Dr. Seeds explores the difference between replicative vs. functional senescence, revealing why the telomere hype may be missing the bigger picture in post-mitotic cells like neurons, heart, and skeletal muscle.
Dr. Seeds opens up about his family tree in part one of a personal case study. He recounts his grandfather Elmore, a pioneer of nuclear medicine, and his father Asa, who helped establish maternal-fetal medicine, plus the habit of questioning everything that shaped his path into cellular medicine.
- Should bodybuilders use collagen? Research-backed guidance on its role in training and tissue repair. [0:38]
- Mitochondrial myopathy, Hashimoto’s, and asthma in a 64 y/o female—how to improve strength and respiratory resilience. [11:23]
- Post-liver lobectomy with PCOS and poor sleep; peptide suggestions. [22:32]
Veterinary epidemiologist Dr. Stephanie Venn-Watson recounts how studying Navy dolphins uncovered C15, or pentadecanoic acid, the first essential fatty acid identified in over 90 years. She and Dr. Seeds explore cellular fragility syndrome, how C15 strengthens cell membranes, and its roles in signaling, metabolism, and epigenetic regulation.
Beyond Energy: How Mitochondria Adapt to Life
This month on Rabbit Holes, Dr. Seeds challenges the reductionist view of mitochondria as “the powerhouse of the cell.” He takes us deep into how mitochondria regulate energy, metabolism, morphology, and redox — and why their ability to adapt is at the core of preventing dysfunction, disease, and decline.
Whether you’re working with clients, patients, or protocols, this episode will give you the context needed to understand cellular adaptation and its real-life clinical relevance.
Methylene blue gets scrutinized as a redox-cycling agent that shuttles electrons past damaged complexes in the electron transport chain. Dr. Seeds defends its role in specific disease states while warning that its inhibition of nitric oxide and blocking of mitochondrial adaptation make it a poor choice for healthy people chasing performance.
Is TA1 Underdosed in Sepsis?
In this episode, Dr. Seeds breaks down a recent clinical trial on Thymosin Alpha-1 in sepsis, weighing its results against real-world application. Learn why dosing, biomarkers, and peptide combinations like TB4 matter more than ever.
NAD gets a hard look as Dr. Seeds challenges the booming infusion industry. He explains NAD's real role as a redox cofactor and sirtuin substrate, why CD38 sinks and senescent cells grab it first, and why the energy rush people feel is a false, catecholamine-driven signal rather than new ATP.
Can Walnuts Boost Brain Power?
Dr. Seeds reviews a study on how a walnut-rich breakfast affects cognition and mood in healthy adults.
The episode explores glucose metabolism, brain performance, and the potential of food as a clinical tool. (Article Link)
Is metformin really an anti-aging drug? Dr. Seeds pushes back on the longevity hype, noting the diabetes medication inhibits mitochondrial complex I, the very electron-transport machinery cellular medicine aims to strengthen. He examines the Horvath clock and telomere claims, and studies showing its mortality benefits may be short-lived.
Omega-3 vs Omega-6: What Really Matters
In this episode of Rabbit Holes, Dr. Seeds unpacks the delicate balance between pro- and anti-inflammatory fats, breaking down how omega-3 and omega-6 fatty acids impact your health—from immune response to chronic inflammation.
In this third book, Dr. Seeds offers readers a concise guide to both the research and clinical applications of GLP-1s and other peptides. This book is intended to empower medical professionals and individuals who want to be part of a healthcare movement committed not only to longevity but to optimal healthspan.