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Mark Newman, founder of Precision Analytical and creator of the DUTCH test, explains how dried urine testing captures a dynamic, functional picture of hormone metabolism. He and Dr. Seeds discuss retiring the old estrogen metabolism pie chart, the need for scientific humility, and building reports clinicians can actually interpret.
Are GLP-1s Causing Muscle Loss? Here’s What to Do.
Building on his book The Quantum Power of GLP-1 Peptides, Dr. Seeds shares a gentler alternative to intermittent fasting: a four-day graded calorie restriction cycle. The talk covers how catabolism, AMPK, cortisol, and thyroid interact, why constant fasting can backfire, and how cycling supports the microbiome and cellular adaptation.
How Vitamin B3 May Help Reduce Skin Cancer Risk
Dr. Seeds reviews a large-scale clinical study on nicotinamide (vitamin B3) and its ability to reduce skin cancer risk. He explains how nicotinamide supports DNA repair and immune balance in keratinocytes following UV exposure—showing up to a 50% reduction in secondary skin cancers. A fascinating look at how cellular repair pathways, NAD metabolism, and targeted supplementation intersect in the prevention of UV-induced disease. (Article Link)
Wellness thought leader Lea Llovio joins to explore how belief, mindset, and emotional interference shape healing. She and Dr. Seeds discuss why both patient and practitioner need genuine investment for protocols to work, how guilt and negative thought patterns block progress, and the practice of radical self-acceptance.
Sodium, Glucose Pathways, and Liver Health
Exercise may be the brain's best medicine. Dr. Seeds details how resistance training and aerobic work raise BDNF through muscle-derived irisin, lactate fueling, and the AMPK to PGC-1 alpha pathway. The result is stronger synaptic plasticity, sharper cognition, and greater resilience against inflammation and insulin resistance.
October 2025 Office Hours
1. Metabolic, hormonal, and psychological recovery in complex perimenopausal case [0:43]
2. Measure peptide outcomes beyond symptoms and track mitochondrial flexibility [15:02]
3. Strategies for treating recurrent, therapy-resistant C. diff colitis [26:20]
4. Mitochondrial case centered on enhancing muscle strength and respiratory resilience [30:42]
Your cells run on 24-hour rhythms coordinated by a master clock in the hypothalamus. Dr. Seeds explains how morning light resets the system, why insulin sensitivity and AMPK peak early while mTOR favors afternoon training, and how NAD salvage and sirtuin activation set up nightly cellular repair.
GLP-1 Not Working Like It Used To? Here’s What to Do Next.
A pre-print trial claiming semaglutide slows epigenetic aging in HIV patients with lipohypertrophy sparks a pointed discussion of methylation clocks. Dr. Seeds argues these aging biomarkers predict morbidity and mortality but should not replace validated mechanisms, walking through how GLP-1s act on AMPK, mTOR and brain plasticity that he says already prove their value.
Semaglutide Slows Epigenetic Aging in People with HIV-associated 3 lipohypertrophy: Evidence from a Randomized Controlled Trial
Dr. Seeds reviews a new study on GLP-1 receptor agonists and their potential to slow biological aging in HIV patients, measured through DNA methylation clocks. He highlights both the promising findings on inflammation, brain, and heart aging. (Article Link)
NAC vs. IV Glutathione
Is IV Glutathione Overrated?
Dr. Seeds clears up the confusion between IV glutathione and oral N-acetylcysteine (NAC). What’s more effective for long-term glutathione support? He breaks down the science, including why IV glutathione may not work the way you think—and when it can be useful. From biochemical breakdowns to clinical use cases, this episode is packed with clarity on one of the most misunderstood antioxidant strategies.
Fasting, Food & Peptides
In this episode, Dr. Seeds answers a common question: Do peptides need to be taken on an empty stomach? He explains why growth hormone secretagogues like CJC/Ipamorelin are best taken fasted, why oral BPC and KPV stand out, and how carbs, fats, and insulin impact growth hormone pulses. With practical guidance on timing and a clear look at the science, this episode offers members the clarity they need to optimize peptide use.
Creatine gets demystified as far more than a bodybuilding staple. Dr. Seeds frames it as an on-demand ATP battery built through phosphocreatine in the mitochondria, then explores its reach into brain energy, glutamate recycling, anxiety, and methylation. The team also untangles the creatine versus creatinine confusion.
Can one year of heavy lifting change the course of aging?
Dr. Seeds unpacks the groundbreaking LISA Study, which tracked older adults over four years after just one year of resistance training. The results? Remarkable strength preservation, visceral fat control, and evidence of long-term neuromuscular adaptation—especially in women.
Explore why strength—not just muscle mass—matters for health span, and how these findings reinforce the cellular medicine approach to aging, recovery, and metabolic resilience. (Article Link)
Emergency medicine physician and SSRP faculty member Dr. Siobhan Newman shares how frustration with reactive care drew her toward cellular medicine. She discusses personalizing treatment for complex neurodegenerative and autoimmune cases, why the word longevity can ring hollow, and how family and community anchor lasting health outcomes.
Resistance is Vital: Training for Healthspan
Dr. Seeds unpacks why resistance training is one of the most effective tools for preserving muscle, improving mitochondrial function, and extending health span—especially in older adults. He connects key cellular pathways like AMPK, mTOR, and PGC-1α to real-world outcomes like strength retention, metabolic flexibility, and reduced inflammation. With new long-term data from the LESA study, this episode offers essential insight for anyone focused on aging well through the lens of cellular medicine.