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1. Idiopathic pulmonary fibrosis in patient already receiving immunosuppressive therapy (1:01)
2. Peptide considerations for a 14-year-old diagnosed with “internal preoccupation” (28:44)
3. Patient with hypermobility, mitochondrial dysfunction, and mast cell activation after COVID (39:48)
Ubiquinol, the reduced form of CoQ10, gets a careful reassessment as a mitochondrial electron carrier. Dr. Seeds explains its genuine value for people on statins, which block CoQ10 synthesis, while pushing back on marketing that frames it as a universal energy or longevity supplement for already-healthy individuals.
The Cellular Impact of UVA vs. UVB Light (Part 1)
In this Rabbit Holes episode, Dr. Seeds explains the mechanistic differences between UVA and UVB light, highlighting how each spectrum uniquely contributes to photoaging, oxidative stress, DNA damage, and skin cancer risk. He also outlines cellular strategies to support antioxidant defenses, mitochondrial function, and DNA repair in response to chronic light exposure.
Want to learn more? Check out Mastermind 15 on Aesthetics!
Can you teach an old brain new tricks? Dr. Seeds distinguishes neurogenesis from the synaptic plasticity that actually keeps the brain adaptable, tracing the glutamate-to-BDNF cascade. Exercise, sleep and glymphatic drainage, nutrition, novelty, and social connection all emerge as levers for lasting cognitive resilience.
BPC-157 vs. TB-500: Evaluating Unexpected Joint Symptoms
Dr. Seeds reviews a case of swelling, joint stiffness, and tingling that appeared after stacking BPC-157 with TB-500, using it as a framework for thinking through peptide reactions, sourcing, and causality. (Question Link)
Coffee acts less as fuel and more as a neuromodulator. Dr. Seeds breaks down how caffeine blocks adenosine A1 and A2A receptors to boost dopamine, acetylcholine and alertness, why it can mask HPA-axis dysregulation in stressed bodies, and what chlorogenic acids and polyphenols mean for gut and metabolic health.
Sleep Through the Lens of Cellular Medicine
In this episode of Rabbit Holes, Dr. Seeds discusses how light exposure, thermal regulation, and autonomic signaling influence sleep, circadian rhythm, and mitochondrial health through the lens of cellular medicine.
Guest Damian Hancock, CEO of Spectrum X, joins to discuss a drug-grade NAD+ formulation delivered through a single-use injection pen modeled on GLP-1 devices. The conversation centers on manufacturing quality, endotoxin and sterility concerns with compounded NAD, and why standardized dosing gives prescribers a reliable baseline.
The Effects of AG1® Supplementation on the Gut Microbiome of Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Dr. Seeds reviews a randomized controlled study on AG1 and its potential impact on the gut microbiome. The research shows short-term probiotic survival and safety but no significant changes in microbiome diversity or systemic metabolic effects. Dr. Seeds discusses what the study supports, what it doesn’t, and why careful interpretation of research matters in clinical practice. (Article Link)
A New York Times report on gray-market Chinese peptides flooding Silicon Valley frames this discussion of sourcing, safety, and FDA oversight. Dr. Seeds contrasts 503A compounded peptides under physician supervision with unregulated research chemicals, and pushes back on reckless claims like nasal oxytocin being Ozempic for autism.
1. Post-chemotherapy fatigue and neuropathy in a colorectal cancer survivor peptide safety and immune support (0:48)
2. Severe food reactivity with mast cell involvement and redox imbalance (07:50)
3. Severe pediatric JIA with MIS-C and persistent hyperinflammation (23:34)
As AI tools like ChatGPT move into clinics and prescription renewals, Dr. Seeds weighs their real limits against the hype. He argues pattern-matching software cannot interpret changing patient biology or replace mechanistic reasoning, while acknowledging AI can help synthesize histories and structure data when used as a support tool.
Rethinking OCD Through a Cellular Medicine Lens
Dr. Seeds explores OCD as a circuitry and maladaptive learning issue, discussing neurotransmitter balance, oxidative stress, and mitochondrial function while highlighting a non-SSRI approach that pairs cellular support with ERP to promote lasting change. Question Link
Alzheimer's gets reframed as a phenotype rather than a single plaque disease. The discussion breaks down five converging drivers: amyloid and tau from lost proteostasis, microglial neuroinflammation, mitochondrial energy failure, vascular dysfunction, and insulin resistance, all tracing back to oxidative stress in the neuron over decades.
The Truth About Ketone Esters
The gut and brain talk constantly. Dr. Seeds walks through how barrier breakdown, low-grade immune activation, and vagus-nerve signaling connect a struggling microbiome to neurodegeneration. Short-chain fatty acids like butyrate, dietary fiber, and metabolite signaling take center stage over simplistic good-versus-bad bug thinking.
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Dr. Seeds reviews a newly published peer-reviewed article, coauthored with his colleagues, examining how cellular medicine and peptides support orthopedic wound healing through regenerative signaling and cellular repair mechanisms. (Article Link)
Fresh off a review paper published in JAAOS Global Research and Reviews with co-authors Dr. Omar Raman and Dr. Stephen Lee, Dr. Seeds discusses therapeutic peptides in orthopedics. The conversation covers wound-healing agents like BPC-157 and GHK-Cu, growth hormone secretagogues, and the need for rigorous clinical trials.