Resource Library

Coffee acts less as fuel and more as a neuromodulator. Dr. Seeds breaks down how caffeine blocks adenosine A1 and A2A receptors to boost dopamine, acetylcholine and alertness, why it can mask HPA-axis dysregulation in stressed bodies, and what chlorogenic acids and polyphenols mean for gut and metabolic health.

Guest Damian Hancock, CEO of Spectrum X, joins to discuss a drug-grade NAD+ formulation delivered through a single-use injection pen modeled on GLP-1 devices. The conversation centers on manufacturing quality, endotoxin and sterility concerns with compounded NAD, and why standardized dosing gives prescribers a reliable baseline.

A New York Times report on gray-market Chinese peptides flooding Silicon Valley frames this discussion of sourcing, safety, and FDA oversight. Dr. Seeds contrasts 503A compounded peptides under physician supervision with unregulated research chemicals, and pushes back on reckless claims like nasal oxytocin being Ozempic for autism.

As AI tools like ChatGPT move into clinics and prescription renewals, Dr. Seeds weighs their real limits against the hype. He argues pattern-matching software cannot interpret changing patient biology or replace mechanistic reasoning, while acknowledging AI can help synthesize histories and structure data when used as a support tool.

Alzheimer's gets reframed as a phenotype rather than a single plaque disease. The discussion breaks down five converging drivers: amyloid and tau from lost proteostasis, microglial neuroinflammation, mitochondrial energy failure, vascular dysfunction, and insulin resistance, all tracing back to oxidative stress in the neuron over decades.

The gut and brain talk constantly. Dr. Seeds walks through how barrier breakdown, low-grade immune activation, and vagus-nerve signaling connect a struggling microbiome to neurodegeneration. Short-chain fatty acids like butyrate, dietary fiber, and metabolite signaling take center stage over simplistic good-versus-bad bug thinking.

Fresh off a review paper published in JAAOS Global Research and Reviews with co-authors Dr. Omar Raman and Dr. Stephen Lee, Dr. Seeds discusses therapeutic peptides in orthopedics. The conversation covers wound-healing agents like BPC-157 and GHK-Cu, growth hormone secretagogues, and the need for rigorous clinical trials.

A single 81 mg aspirin does far more than thin blood. Dr. Seeds explains how acetylation shuts down COX-1 while retasking COX-2 to produce pro-resolving mediators like resolvins and lipoxins from omega-3s, plus its effects on the cGAS-STING pathway, PPAR alpha and the resolution of chronic inflammation, along with who should avoid it.

Red light therapy and cold plunge headline this look at popular rejuvenation tools and where the marketing outruns the science. Dr. Seeds explains how red light sparks the electron transport chain and cytochrome c oxidase to support soft-tissue healing and skin, while cautioning that its effects stay superficial and short-lived.

A back-to-basics look at cellular medicine, told by the innovator behind the framework. Dr. Seeds lays out four pillars: redox balance, mitochondrial signaling, core metabolic pathways, and cellular resilience, then traces how his orthopedic practice revealed that treating the cellular environment, not just the diagnosis, changes patient outcomes.