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Dr. Seeds reframes modern care around phenotyping rather than treating symptoms or diagnoses, explaining why peptides work as signaling molecules that help cells make better decisions. Matt and Maddie also preview the Peptide World Congress and the launch of a graduate-level cellular medicine course.
Aging-Associated Decline of Phosphatidylcholine Synthesis is a Malleable Trigger of Natural Mitochondrial Aging
Dr. Seeds explores how age-related decline in phosphatidylcholine synthesis may contribute to mitochondrial aging and why that matters in Cellular Medicine. This discussion connects membrane integrity, mitochondrial function, methylation, and metabolic resilience, while highlighting how this pathway may be more modifiable than we once thought.
The FDA has announced safety and efficacy reviews of roughly a dozen compounded peptides, including BPC-157, TB-500, DSIP and Melanotan 2, moving several off the restricted category 2 list. Dr. Seeds unpacks the PCAC review process, API manufacturing standards, and why preclinical mechanisms still need human clinical evidence.
1. Managing shingles outbreaks in GLP-1 patient through peptides (0:40)
2. Peptide strategies in suspected ALS (15:56)
3. Improving durability in dementia treatment (25:08)
Dr. Seeds separates stretching fact from gym-floor fallacy, explaining why static holds before training can backfire while dynamic mobility work prepares the body. He digs into the molecular payoff of stretching done correctly, from inhibiting myostatin and boosting follistatin to adding sarcomeres in series for better contraction velocity.
In this bonus episode from the MM15 Virtual Summit, Dr. Seeds addresses an important question around the use of GLP-1s for metabolic balancing in patients who do not need to lose weight. He shares his perspective on what may be considered microdosing, along with the clinical thought process he uses when determining appropriate dosing in these more nuanced cases.
Additional questions from the MM15 Virtual Summit can be found in our accompanying article here: [insert article link]
Access the full MM15 Course here: Mastermind 15 on Aesthetics
Dr. Seeds walks Matt and Maddie through the nine B vitamins, from thiamine and riboflavin to folate and B12, explaining absorption pitfalls, over-fortification, and toxicity risks. The conversation digs into homocysteine, one-carbon metabolism, and the MTHFR gene variants that shape methylation and neurotransmitter production.
The Limits of Alternative Peptide Delivery
Dr. Seeds reviews oral, sublingual, and transdermal peptide delivery, and explains why subcutaneous injection remains the gold standard for most peptides. (Question Link)
Magnesium comes in many forms, and this discussion breaks down how glycinate, citrate, threonate, and others carry the mineral to different tissues. Matt and Dr. Seeds cover why soil depletion and poor diets leave many people short, how magnesium moves into cells and mitochondria, and when true repletion matters.
A Deeper Look at the RAAS System
Dr. Seeds uses this Rabbit Holes episode to build on Journal Club Episode 87, revisiting the renin-angiotensin-aldosterone system and its broader role in cellular signaling. The discussion focuses on receptor balance, local tissue effects, and the mechanisms linking RAS disruption to inflammation, fibrosis, and mitochondrial stress.(Article Link)