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In this bonus episode from the MM15 Virtual Summit, Dr. Seeds addresses an important question around the use of GLP-1s for metabolic balancing in patients who do not need to lose weight. He shares his perspective on what may be considered microdosing, along with the clinical thought process he uses when determining appropriate dosing in these more nuanced cases.
Additional questions from the MM15 Virtual Summit can be found in our accompanying article here: [insert article link]
Access the full MM15 Course here: Mastermind 15 on Aesthetics
Dr. Seeds walks Matt and Maddie through the nine B vitamins, from thiamine and riboflavin to folate and B12, explaining absorption pitfalls, over-fortification, and toxicity risks. The conversation digs into homocysteine, one-carbon metabolism, and the MTHFR gene variants that shape methylation and neurotransmitter production.
The Limits of Alternative Peptide Delivery
Dr. Seeds reviews oral, sublingual, and transdermal peptide delivery, and explains why subcutaneous injection remains the gold standard for most peptides. (Question Link)
Magnesium comes in many forms, and this discussion breaks down how glycinate, citrate, threonate, and others carry the mineral to different tissues. Matt and Dr. Seeds cover why soil depletion and poor diets leave many people short, how magnesium moves into cells and mitochondria, and when true repletion matters.
A Deeper Look at the RAAS System
Dr. Seeds uses this Rabbit Holes episode to build on Journal Club Episode 87, revisiting the renin-angiotensin-aldosterone system and its broader role in cellular signaling. The discussion focuses on receptor balance, local tissue effects, and the mechanisms linking RAS disruption to inflammation, fibrosis, and mitochondrial stress.(Article Link)
Matt, Maddie, and Dr. Seeds unpack why rapid weight loss on GLP-1 medications can leave the face looking sunken and prematurely aged. The real driver is collagen and elastin failing to keep pace with fat compartment loss, compounded by declining estrogen and mitochondrial inefficiency in women near menopause.
The Renin–Angiotensin–Aldosterone System (RAAS): Beyond Cardiovascular Regulation
Dr. Seeds unpacks how RAS receptor balance drives inflammation, fibrosis, mitochondrial dysfunction, and tissue remodeling, far beyond its classical role in blood pressure regulation. (Article Link)
Is hair loss truly genetic? Dr. Seeds breaks down the four types of alopecia and why the follicle's own ecosystem, DHT sensitivity, mitochondrial energy, and scalp fibrosis matter more than a single gene. The talk covers biotin's real role plus regenerative options like microneedling, PRP, and GHK-Cu.
1. SSRI tapering resistance, anxiety during weaning (0:40)
2. Progressive multifocal dystonia (13:27)
3. Complex type 2 diabetes case in a lean, athletic patient (28:32)
Skin aging splits into intrinsic mitochondrial decline and extrinsic damage, with UV light driving roughly 80 percent of visible changes. Dr. Seeds explains UVA versus UVB, the mitochondrial DNA 4977 deletion behind photoaging, Asian PA sunscreen ratings, vitamin D synthesis, and how the peptide Melanotan stimulates protective melanin.
Peptide Pharmacokinetics
Dissecting Protocols, Dr. Seeds breaks down the reasoning behind SubQ vs. IM peptide administration. From pharmacokinetic considerations to the growing misuse of combining peptides with oil-based medications in the same syringe, this discussion helps clarify proper application and safety considerations.