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Matt, Maddie, and Dr. Seeds unpack why rapid weight loss on GLP-1 medications can leave the face looking sunken and prematurely aged. The real driver is collagen and elastin failing to keep pace with fat compartment loss, compounded by declining estrogen and mitochondrial inefficiency in women near menopause.
The Renin–Angiotensin–Aldosterone System (RAAS): Beyond Cardiovascular Regulation
Dr. Seeds unpacks how RAS receptor balance drives inflammation, fibrosis, mitochondrial dysfunction, and tissue remodeling, far beyond its classical role in blood pressure regulation. (Article Link)
Is hair loss truly genetic? Dr. Seeds breaks down the four types of alopecia and why the follicle's own ecosystem, DHT sensitivity, mitochondrial energy, and scalp fibrosis matter more than a single gene. The talk covers biotin's real role plus regenerative options like microneedling, PRP, and GHK-Cu.
1. SSRI tapering resistance, anxiety during weaning (0:40)
2. Progressive multifocal dystonia (13:27)
3. Complex type 2 diabetes case in a lean, athletic patient (28:32)
Skin aging splits into intrinsic mitochondrial decline and extrinsic damage, with UV light driving roughly 80 percent of visible changes. Dr. Seeds explains UVA versus UVB, the mitochondrial DNA 4977 deletion behind photoaging, Asian PA sunscreen ratings, vitamin D synthesis, and how the peptide Melanotan stimulates protective melanin.
Peptide Pharmacokinetics
Dissecting Protocols, Dr. Seeds breaks down the reasoning behind SubQ vs. IM peptide administration. From pharmacokinetic considerations to the growing misuse of combining peptides with oil-based medications in the same syringe, this discussion helps clarify proper application and safety considerations.
Urolithin A, a postbiotic your gut makes from pomegranate, walnuts and berries, takes center stage in this look at mitophagy and mitochondrial renewal. Dr. Seeds reviews human trials showing improved oxidative phosphorylation in immune cells, why roughly 40 percent of people cannot produce it naturally, and its role in supporting vaccination response as we age.
The Cellular Impact of UVA vs. UVB Light (Part 2)
Dr. Seeds continues this Rabbit Hole on UVA vs. UVB light in Part 2, covering oxidative stress, skin aging, vitamin D synthesis, and the risks of tanning beds. A helpful look at why not all UV exposure works the same, why that distinction matters, and how it shapes both skin health and cellular function
Catch Part 1 (Rabbit Holes – Ep. 081) HERE
Facial plastic surgeon Keith Marcus and nurse Kristen Nagarian share how they folded cellular medicine into their aesthetic practice after joining the SSRP. The conversation traces their path from clinical research and surgery toward a root-cause approach, reframing aesthetics as work that happens from the inside out.
Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients
Dr. Seeds discusses this article on low dose minoxidil for hair loss and shares why a lower, slower dosing approach may lead to better outcomes. He also reviews key safety considerations, side effects, and practical dosing insights for both men and women. (Article Link)
Drawing on decades as an orthopedic and sports medicine surgeon, Dr. Seeds reframes recovery from sports injuries around cellular mechanisms rather than wear and tear. The episode explores tendon and muscle repair, TGF-beta signaling, cartilage degeneration, overtraining, sarcopenia, and the load adaptation that keeps joints resilient with age.
1. Idiopathic pulmonary fibrosis in patient already receiving immunosuppressive therapy (1:01)
2. Peptide considerations for a 14-year-old diagnosed with “internal preoccupation” (28:44)
3. Patient with hypermobility, mitochondrial dysfunction, and mast cell activation after COVID (39:48)
Ubiquinol, the reduced form of CoQ10, gets a careful reassessment as a mitochondrial electron carrier. Dr. Seeds explains its genuine value for people on statins, which block CoQ10 synthesis, while pushing back on marketing that frames it as a universal energy or longevity supplement for already-healthy individuals.
The Cellular Impact of UVA vs. UVB Light (Part 1)
In this Rabbit Holes episode, Dr. Seeds explains the mechanistic differences between UVA and UVB light, highlighting how each spectrum uniquely contributes to photoaging, oxidative stress, DNA damage, and skin cancer risk. He also outlines cellular strategies to support antioxidant defenses, mitochondrial function, and DNA repair in response to chronic light exposure.
Want to learn more? Check out Mastermind 15 on Aesthetics!
Can you teach an old brain new tricks? Dr. Seeds distinguishes neurogenesis from the synaptic plasticity that actually keeps the brain adaptable, tracing the glutamate-to-BDNF cascade. Exercise, sleep and glymphatic drainage, nutrition, novelty, and social connection all emerge as levers for lasting cognitive resilience.
BPC-157 vs. TB-500: Evaluating Unexpected Joint Symptoms
Dr. Seeds reviews a case of swelling, joint stiffness, and tingling that appeared after stacking BPC-157 with TB-500, using it as a framework for thinking through peptide reactions, sourcing, and causality. (Question Link)