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Urolithin A, a postbiotic your gut makes from pomegranate, walnuts and berries, takes center stage in this look at mitophagy and mitochondrial renewal. Dr. Seeds reviews human trials showing improved oxidative phosphorylation in immune cells, why roughly 40 percent of people cannot produce it naturally, and its role in supporting vaccination response as we age.
The Cellular Impact of UVA vs. UVB Light (Part 2)
Dr. Seeds continues this Rabbit Hole on UVA vs. UVB light in Part 2, covering oxidative stress, skin aging, vitamin D synthesis, and the risks of tanning beds. A helpful look at why not all UV exposure works the same, why that distinction matters, and how it shapes both skin health and cellular function
Catch Part 1 (Rabbit Holes – Ep. 081) HERE
Facial plastic surgeon Keith Marcus and nurse Kristen Nagarian share how they folded cellular medicine into their aesthetic practice after joining the SSRP. The conversation traces their path from clinical research and surgery toward a root-cause approach, reframing aesthetics as work that happens from the inside out.
Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients
Dr. Seeds discusses this article on low dose minoxidil for hair loss and shares why a lower, slower dosing approach may lead to better outcomes. He also reviews key safety considerations, side effects, and practical dosing insights for both men and women. (Article Link)
Drawing on decades as an orthopedic and sports medicine surgeon, Dr. Seeds reframes recovery from sports injuries around cellular mechanisms rather than wear and tear. The episode explores tendon and muscle repair, TGF-beta signaling, cartilage degeneration, overtraining, sarcopenia, and the load adaptation that keeps joints resilient with age.
1. Idiopathic pulmonary fibrosis in patient already receiving immunosuppressive therapy (1:01)
2. Peptide considerations for a 14-year-old diagnosed with “internal preoccupation” (28:44)
3. Patient with hypermobility, mitochondrial dysfunction, and mast cell activation after COVID (39:48)
Ubiquinol, the reduced form of CoQ10, gets a careful reassessment as a mitochondrial electron carrier. Dr. Seeds explains its genuine value for people on statins, which block CoQ10 synthesis, while pushing back on marketing that frames it as a universal energy or longevity supplement for already-healthy individuals.
The Cellular Impact of UVA vs. UVB Light (Part 1)
In this Rabbit Holes episode, Dr. Seeds explains the mechanistic differences between UVA and UVB light, highlighting how each spectrum uniquely contributes to photoaging, oxidative stress, DNA damage, and skin cancer risk. He also outlines cellular strategies to support antioxidant defenses, mitochondrial function, and DNA repair in response to chronic light exposure.
Want to learn more? Check out Mastermind 15 on Aesthetics!
Can you teach an old brain new tricks? Dr. Seeds distinguishes neurogenesis from the synaptic plasticity that actually keeps the brain adaptable, tracing the glutamate-to-BDNF cascade. Exercise, sleep and glymphatic drainage, nutrition, novelty, and social connection all emerge as levers for lasting cognitive resilience.
BPC-157 vs. TB-500: Evaluating Unexpected Joint Symptoms
Dr. Seeds reviews a case of swelling, joint stiffness, and tingling that appeared after stacking BPC-157 with TB-500, using it as a framework for thinking through peptide reactions, sourcing, and causality. (Question Link)
Coffee acts less as fuel and more as a neuromodulator. Dr. Seeds breaks down how caffeine blocks adenosine A1 and A2A receptors to boost dopamine, acetylcholine and alertness, why it can mask HPA-axis dysregulation in stressed bodies, and what chlorogenic acids and polyphenols mean for gut and metabolic health.
Sleep Through the Lens of Cellular Medicine
In this episode of Rabbit Holes, Dr. Seeds discusses how light exposure, thermal regulation, and autonomic signaling influence sleep, circadian rhythm, and mitochondrial health through the lens of cellular medicine.
Guest Damian Hancock, CEO of Spectrum X, joins to discuss a drug-grade NAD+ formulation delivered through a single-use injection pen modeled on GLP-1 devices. The conversation centers on manufacturing quality, endotoxin and sterility concerns with compounded NAD, and why standardized dosing gives prescribers a reliable baseline.
The Effects of AG1® Supplementation on the Gut Microbiome of Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Dr. Seeds reviews a randomized controlled study on AG1 and its potential impact on the gut microbiome. The research shows short-term probiotic survival and safety but no significant changes in microbiome diversity or systemic metabolic effects. Dr. Seeds discusses what the study supports, what it doesn’t, and why careful interpretation of research matters in clinical practice. (Article Link)
A New York Times report on gray-market Chinese peptides flooding Silicon Valley frames this discussion of sourcing, safety, and FDA oversight. Dr. Seeds contrasts 503A compounded peptides under physician supervision with unregulated research chemicals, and pushes back on reckless claims like nasal oxytocin being Ozempic for autism.
1. Post-chemotherapy fatigue and neuropathy in a colorectal cancer survivor peptide safety and immune support (0:48)
2. Severe food reactivity with mast cell involvement and redox imbalance (07:50)
3. Severe pediatric JIA with MIS-C and persistent hyperinflammation (23:34)