Video Library

Cellular Optimization for EDS Surgical Support

Dr. Seeds reviews peptide and supplemental considerations for cellular optimization in an EDS patient preparing for orthopedic surgery. (Question Link)

The Phosphatidylcholine Pathway

Dr. Seeds expands on Journal Club Episode 92 to explore the role of phosphatidylcholine in lipid metabolism, methylation, and mitochondrial integrity during aging. He also highlights how estrogen loss may impact this pathway, especially in pre- and post-menopausal women.

Aging-Associated Decline of Phosphatidylcholine Synthesis is a Malleable Trigger of Natural Mitochondrial Aging

Dr. Seeds explores how age-related decline in phosphatidylcholine synthesis may contribute to mitochondrial aging and why that matters in Cellular Medicine. This discussion connects membrane integrity, mitochondrial function, methylation, and metabolic resilience, while highlighting how this pathway may be more modifiable than we once thought.

1. Managing shingles outbreaks in GLP-1 patient through peptides (0:40)
2. Peptide strategies in suspected ALS (15:56)
3. Improving durability in dementia treatment (25:08)

In this bonus episode from the MM15 Virtual Summit, Dr. Seeds addresses an important question around the use of GLP-1s for metabolic balancing in patients who do not need to lose weight. He shares his perspective on what may be considered microdosing, along with the clinical thought process he uses when determining appropriate dosing in these more nuanced cases.

Additional questions from the MM15 Virtual Summit can be found in our accompanying article here: [insert article link]

Access the full MM15 Course here: Mastermind 15 on Aesthetics

The Limits of Alternative Peptide Delivery

Dr. Seeds reviews oral, sublingual, and transdermal peptide delivery, and explains why subcutaneous injection remains the gold standard for most peptides. (Question Link)

A Deeper Look at the RAAS System

Dr. Seeds uses this Rabbit Holes episode to build on Journal Club Episode 87, revisiting the renin-angiotensin-aldosterone system and its broader role in cellular signaling. The discussion focuses on receptor balance, local tissue effects, and the mechanisms linking RAS disruption to inflammation, fibrosis, and mitochondrial stress.(Article Link)

The Renin–Angiotensin–Aldosterone System (RAAS): Beyond Cardiovascular Regulation

Dr. Seeds unpacks how RAS receptor balance drives inflammation, fibrosis, mitochondrial dysfunction, and tissue remodeling, far beyond its classical role in blood pressure regulation. (Article Link)

1. SSRI tapering resistance, anxiety during weaning (0:40)
2. Progressive multifocal dystonia (13:27)
3. Complex type 2 diabetes case in a lean, athletic patient (28:32)

Peptide Pharmacokinetics

Dissecting Protocols, Dr. Seeds breaks down the reasoning behind SubQ vs. IM peptide administration. From pharmacokinetic considerations to the growing misuse of combining peptides with oil-based medications in the same syringe, this discussion helps clarify proper application and safety considerations.

The Cellular Impact of UVA vs. UVB Light (Part 2)

Dr. Seeds continues this Rabbit Hole on UVA vs. UVB light in Part 2, covering oxidative stress, skin aging, vitamin D synthesis, and the risks of tanning beds. A helpful look at why not all UV exposure works the same, why that distinction matters, and how it shapes both skin health and cellular function

Catch Part 1 (Rabbit Holes – Ep. 081) HERE

Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

Dr. Seeds discusses this article on low dose minoxidil for hair loss and shares why a lower, slower dosing approach may lead to better outcomes. He also reviews key safety considerations, side effects, and practical dosing insights for both men and women. (Article Link)

1. Idiopathic pulmonary fibrosis in patient already receiving immunosuppressive therapy (1:01)
2. Peptide considerations for a 14-year-old diagnosed with “internal preoccupation” (28:44)
3. Patient with hypermobility, mitochondrial dysfunction, and mast cell activation after COVID (39:48)

The Cellular Impact of UVA vs. UVB Light (Part 1)

In this Rabbit Holes episode, Dr. Seeds explains the mechanistic differences between UVA and UVB light, highlighting how each spectrum uniquely contributes to photoaging, oxidative stress, DNA damage, and skin cancer risk. He also outlines cellular strategies to support antioxidant defenses, mitochondrial function, and DNA repair in response to chronic light exposure.

Want to learn more? Check out Mastermind 15 on Aesthetics!

BPC-157 vs. TB-500: Evaluating Unexpected Joint Symptoms

Dr. Seeds reviews a case of swelling, joint stiffness, and tingling that appeared after stacking BPC-157 with TB-500, using it as a framework for thinking through peptide reactions, sourcing, and causality. (Question Link)

Sleep Through the Lens of Cellular Medicine

In this episode of Rabbit Holes, Dr. Seeds discusses how light exposure, thermal regulation, and autonomic signaling influence sleep, circadian rhythm, and mitochondrial health through the lens of cellular medicine.

The Effects of AG1® Supplementation on the Gut Microbiome of Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Dr. Seeds reviews a randomized controlled study on AG1 and its potential impact on the gut microbiome. The research shows short-term probiotic survival and safety but no significant changes in microbiome diversity or systemic metabolic effects. Dr. Seeds discusses what the study supports, what it doesn’t, and why careful interpretation of research matters in clinical practice. (Article Link)

1. Post-chemotherapy fatigue and neuropathy in a colorectal cancer survivor peptide safety and immune support (0:48)
2. Severe food reactivity with mast cell involvement and redox imbalance (07:50)
3. Severe pediatric JIA with MIS-C and persistent hyperinflammation (23:34)

Rethinking OCD Through a Cellular Medicine Lens

Dr. Seeds explores OCD as a circuitry and maladaptive learning issue, discussing neurotransmitter balance, oxidative stress, and mitochondrial function while highlighting a non-SSRI approach that pairs cellular support with ERP to promote lasting change. Question Link

The Truth About Ketone Esters

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

Dr. Seeds reviews a newly published peer-reviewed article, coauthored with his colleagues, examining how cellular medicine and peptides support orthopedic wound healing through regenerative signaling and cellular repair mechanisms. (Article Link)

1. Peptides for fertility (0:40)
2. NAD⁺ and GHK-Cu dosing considerations (10:00)
3. Peptide safety for patient with a stroke and chronic migraines (12:33)

LADA Protocol

Dr. Seeds answers a clinician question on implementing a LADA-focused approach, clarifying peptide sequencing, biomarker monitoring, and expectations around immune modulation, metabolic support, and beta-cell preservation within a cellular medicine framework.

The Cellular Side of Spermidine