Resource Library

Incorporating MOTS-c with NAD

Dr. Seeds breaks down the molecular strategies behind improving metabolic flexibility using MOTS-c and a deeper understanding of NAD salvage pathways. Learn why substrate switching is key for energy efficiency, and how precise interventions—like small molecule NNMT inhibitors—can reshape redox balance and mitochondrial resilience. Whether you’re treating aging, fatigue, insulin resistance, or mitochondrial dysfunction, this is essential education for anyone interested in precision cellular medicine.

Methylene Blue and Misconceptions

This month, Dr. Seeds explores a recent study examining methylene blue’s acute effects on the brain in healthy individuals. He breaks down the cellular mechanisms at play—including oxidative phosphorylation, nitric oxide inhibition, and dose-dependent effects on brain metabolism—and explains why this popular “longevity” compound may be doing more harm than good outside of clinical contexts. (Article Link)

The Telomere Trap

This month on Rabbit Holes, Dr. Seeds challenges one of the most widely misunderstood topics in the longevity space: telomeres.
Are longer telomeres really the key to living longer? Or is the real driver of health span hidden in mitochondrial resilience, redox balance, and functional cell integrity?

In this eye-opening episode, Dr. Seeds explores the difference between replicative vs. functional senescence, revealing why the telomere hype may be missing the bigger picture in post-mitotic cells like neurons, heart, and skeletal muscle.

• Should bodybuilders use collagen? Research-backed guidance on its role in training and tissue repair. [0:38]
• Mitochondrial myopathy, Hashimoto’s, and asthma in a 64 y/o female—how to improve strength and respiratory resilience. [11:23]
• Post-liver lobectomy with PCOS and poor sleep; peptide suggestions. [22:32]

Beyond Energy: How Mitochondria Adapt to Life

This month on Rabbit Holes, Dr. Seeds challenges the reductionist view of mitochondria as “the powerhouse of the cell.” He takes us deep into how mitochondria regulate energy, metabolism, morphology, and redox — and why their ability to adapt is at the core of preventing dysfunction, disease, and decline.

Whether you’re working with clients, patients, or protocols, this episode will give you the context needed to understand cellular adaptation and its real-life clinical relevance.

Is TA1 Underdosed in Sepsis?

In this episode, Dr. Seeds breaks down a recent clinical trial on Thymosin Alpha-1 in sepsis, weighing its results against real-world application. Learn why dosing, biomarkers, and peptide combinations like TB4 matter more than ever.

Can Walnuts Boost Brain Power?

Dr. Seeds reviews a study on how a walnut-rich breakfast affects cognition and mood in healthy adults.
The episode explores glucose metabolism, brain performance, and the potential of food as a clinical tool. (Article Link)

Omega-3 vs Omega-6: What Really Matters

In this episode of Rabbit Holes, Dr. Seeds unpacks the delicate balance between pro- and anti-inflammatory fats, breaking down how omega-3 and omega-6 fatty acids impact your health—from immune response to chronic inflammation.

• • Water retention and GLP-1 sensitivity reveal complex hormone interplay and possible long-term effects of Depo-Provera (0:56)

• • Pentosan Polysulfate for back pain and persistent low nitric oxide despite normal ADMA and multiple treatments (17.29)

From Concept to Clinical Strategy

In this episode, Dr. Seeds evaluates a detailed, phase-based plan submitted by an SSRP member—highlighting where to start, how to sequence, and why clarity matters in cellular-focused protocols.

Insightful, practical, and packed with takeaways for your own clinical journey.

Circadian Clocks & Cellular Consequences

In this Journal Club episode, Dr. Seeds explores how early school schedules disrupt natural rhythms—and what that means for mitochondrial health, gene expression, and recovery.

A must-watch for understanding why time is a molecule in cellular medicine. (Article Link)

Methylation, Muscle & the Epigenome

Explore how epigenetic shifts—like DNA methylation and histone acetylation—link exercise to improved gene expression, redox balance, and cellular resilience. A foundational discussion in the cellular medicine model.

• • Peptides for essential hypertension (1:12)

• • Starting aromatase inhibitors in men with high estrogen conversion during testosterone therapy (23:13)

The Potential Influence of Melatonin on Mitochondrial Quality Control: A Review

This Journal Club session dives into the cellular strategies that boost metabolic flexibility, stress adaptation, and energy efficiency. A must-watch for anyone wanting to understand how the cell stays optimized under pressure. (Article Link)