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A Deeper Look at the RAAS System

Dr. Seeds uses this Rabbit Holes episode to build on Journal Club Episode 87, revisiting the renin-angiotensin-aldosterone system and its broader role in cellular signaling. The discussion focuses on receptor balance, local tissue effects, and the mechanisms linking RAS disruption to inflammation, fibrosis, and mitochondrial stress.(Article Link)

The Renin–Angiotensin–Aldosterone System (RAAS): Beyond Cardiovascular Regulation

Dr. Seeds unpacks how RAS receptor balance drives inflammation, fibrosis, mitochondrial dysfunction, and tissue remodeling, far beyond its classical role in blood pressure regulation. (Article Link)

1. SSRI tapering resistance, anxiety during weaning (0:40)
2. Progressive multifocal dystonia (13:27)
3. Complex type 2 diabetes case in a lean, athletic patient (28:32)

Peptide Pharmacokinetics

Dissecting Protocols, Dr. Seeds breaks down the reasoning behind SubQ vs. IM peptide administration. From pharmacokinetic considerations to the growing misuse of combining peptides with oil-based medications in the same syringe, this discussion helps clarify proper application and safety considerations.

The Cellular Impact of UVA vs. UVB Light (Part 2)

Dr. Seeds continues this Rabbit Hole on UVA vs. UVB light in Part 2, covering oxidative stress, skin aging, vitamin D synthesis, and the risks of tanning beds. A helpful look at why not all UV exposure works the same, why that distinction matters, and how it shapes both skin health and cellular function

Catch Part 1 (Rabbit Holes – Ep. 081) HERE

Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

Dr. Seeds discusses this article on low dose minoxidil for hair loss and shares why a lower, slower dosing approach may lead to better outcomes. He also reviews key safety considerations, side effects, and practical dosing insights for both men and women. (Article Link)

1. Idiopathic pulmonary fibrosis in patient already receiving immunosuppressive therapy (1:01)
2. Peptide considerations for a 14-year-old diagnosed with “internal preoccupation” (28:44)
3. Patient with hypermobility, mitochondrial dysfunction, and mast cell activation after COVID (39:48)

The Cellular Impact of UVA vs. UVB Light (Part 1)

In this Rabbit Holes episode, Dr. Seeds explains the mechanistic differences between UVA and UVB light, highlighting how each spectrum uniquely contributes to photoaging, oxidative stress, DNA damage, and skin cancer risk. He also outlines cellular strategies to support antioxidant defenses, mitochondrial function, and DNA repair in response to chronic light exposure.

Want to learn more? Check out Mastermind 15 on Aesthetics!

BPC-157 vs. TB-500: Evaluating Unexpected Joint Symptoms

Dr. Seeds reviews a case of swelling, joint stiffness, and tingling that appeared after stacking BPC-157 with TB-500, using it as a framework for thinking through peptide reactions, sourcing, and causality. (Question Link)

Sleep Through the Lens of Cellular Medicine

In this episode of Rabbit Holes, Dr. Seeds discusses how light exposure, thermal regulation, and autonomic signaling influence sleep, circadian rhythm, and mitochondrial health through the lens of cellular medicine.

The Effects of AG1® Supplementation on the Gut Microbiome of Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Dr. Seeds reviews a randomized controlled study on AG1 and its potential impact on the gut microbiome. The research shows short-term probiotic survival and safety but no significant changes in microbiome diversity or systemic metabolic effects. Dr. Seeds discusses what the study supports, what it doesn’t, and why careful interpretation of research matters in clinical practice. (Article Link)

1. Post-chemotherapy fatigue and neuropathy in a colorectal cancer survivor peptide safety and immune support (0:48)
2. Severe food reactivity with mast cell involvement and redox imbalance (07:50)
3. Severe pediatric JIA with MIS-C and persistent hyperinflammation (23:34)