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October 2025 Office Hours
1. Metabolic, hormonal, and psychological recovery in complex perimenopausal case [0:43]
2. Measure peptide outcomes beyond symptoms and track mitochondrial flexibility [15:02]
3. Strategies for treating recurrent, therapy-resistant C. diff colitis [26:20]
4. Mitochondrial case centered on enhancing muscle strength and respiratory resilience [30:42]
GLP-1 Not Working Like It Used To? Here’s What to Do Next.
Semaglutide Slows Epigenetic Aging in People with HIV-associated 3 lipohypertrophy: Evidence from a Randomized Controlled Trial
Dr. Seeds reviews a new study on GLP-1 receptor agonists and their potential to slow biological aging in HIV patients, measured through DNA methylation clocks. He highlights both the promising findings on inflammation, brain, and heart aging. (Article Link)
NAC vs. IV Glutathione
Is IV Glutathione Overrated?
Dr. Seeds clears up the confusion between IV glutathione and oral N-acetylcysteine (NAC). What’s more effective for long-term glutathione support? He breaks down the science, including why IV glutathione may not work the way you think—and when it can be useful. From biochemical breakdowns to clinical use cases, this episode is packed with clarity on one of the most misunderstood antioxidant strategies.
Fasting, Food & Peptides
In this episode, Dr. Seeds answers a common question: Do peptides need to be taken on an empty stomach? He explains why growth hormone secretagogues like CJC/Ipamorelin are best taken fasted, why oral BPC and KPV stand out, and how carbs, fats, and insulin impact growth hormone pulses. With practical guidance on timing and a clear look at the science, this episode offers members the clarity they need to optimize peptide use.
Can one year of heavy lifting change the course of aging?
Dr. Seeds unpacks the groundbreaking LISA Study, which tracked older adults over four years after just one year of resistance training. The results? Remarkable strength preservation, visceral fat control, and evidence of long-term neuromuscular adaptation—especially in women.
Explore why strength—not just muscle mass—matters for health span, and how these findings reinforce the cellular medicine approach to aging, recovery, and metabolic resilience. (Article Link)
Resistance is Vital: Training for Healthspan
Dr. Seeds unpacks why resistance training is one of the most effective tools for preserving muscle, improving mitochondrial function, and extending health span—especially in older adults. He connects key cellular pathways like AMPK, mTOR, and PGC-1α to real-world outcomes like strength retention, metabolic flexibility, and reduced inflammation. With new long-term data from the LESA study, this episode offers essential insight for anyone focused on aging well through the lens of cellular medicine.
- Exploring metformin for muscle health vs impared mitochondrial function and blunt adaptation to exercise? [01:15]
- Chronic Bartonella symptoms using a cellular approach before antibiotics? [17:04]
- OS-1 peptide for hair growth? [36:21]
Incorporating MOTS-c with NAD
Dr. Seeds breaks down the molecular strategies behind improving metabolic flexibility using MOTS-c and a deeper understanding of NAD salvage pathways. Learn why substrate switching is key for energy efficiency, and how precise interventions—like small molecule NNMT inhibitors—can reshape redox balance and mitochondrial resilience. Whether you’re treating aging, fatigue, insulin resistance, or mitochondrial dysfunction, this is essential education for anyone interested in precision cellular medicine.
Methylene Blue and Misconceptions
This month, Dr. Seeds explores a recent study examining methylene blue’s acute effects on the brain in healthy individuals. He breaks down the cellular mechanisms at play—including oxidative phosphorylation, nitric oxide inhibition, and dose-dependent effects on brain metabolism—and explains why this popular “longevity” compound may be doing more harm than good outside of clinical contexts. (Article Link)
The Telomere Trap
This month on Rabbit Holes, Dr. Seeds challenges one of the most widely misunderstood topics in the longevity space: telomeres.
Are longer telomeres really the key to living longer? Or is the real driver of health span hidden in mitochondrial resilience, redox balance, and functional cell integrity?
In this eye-opening episode, Dr. Seeds explores the difference between replicative vs. functional senescence, revealing why the telomere hype may be missing the bigger picture in post-mitotic cells like neurons, heart, and skeletal muscle.
- Should bodybuilders use collagen? Research-backed guidance on its role in training and tissue repair. [0:38]
- Mitochondrial myopathy, Hashimoto’s, and asthma in a 64 y/o female—how to improve strength and respiratory resilience. [11:23]
- Post-liver lobectomy with PCOS and poor sleep; peptide suggestions. [22:32]
Beyond Energy: How Mitochondria Adapt to Life
This month on Rabbit Holes, Dr. Seeds challenges the reductionist view of mitochondria as “the powerhouse of the cell.” He takes us deep into how mitochondria regulate energy, metabolism, morphology, and redox — and why their ability to adapt is at the core of preventing dysfunction, disease, and decline.
Whether you’re working with clients, patients, or protocols, this episode will give you the context needed to understand cellular adaptation and its real-life clinical relevance.
Is TA1 Underdosed in Sepsis?
In this episode, Dr. Seeds breaks down a recent clinical trial on Thymosin Alpha-1 in sepsis, weighing its results against real-world application. Learn why dosing, biomarkers, and peptide combinations like TB4 matter more than ever.
Can Walnuts Boost Brain Power?
Dr. Seeds reviews a study on how a walnut-rich breakfast affects cognition and mood in healthy adults.
The episode explores glucose metabolism, brain performance, and the potential of food as a clinical tool. (Article Link)