Mastermind 14: The Brain Code
A new framework on neurocognitive dysfunction to interpret mitochondrial and redox mechanisms for clearer clinical reasoning, to support clinical decision-making.
For clinicians working with cognitive decline and complex cases.
In this advanced-level, 32-lesson mastermind, Dr. Seeds explores the intricate cellular pathways behind a number of neurodegenerative diseases, isolating the mechanistic issues that can set off neuronal degradation. He begins by defining neurodegenerative disease as an “energy crisis” in the cellular apparatus. Through an in-depth examination of the role of microglial cells in protecting the brain; the immune crosstalk with the CNS; and the role of astrocytes, the metabolic intermediaries of the brain, Dr. Seeds offers crucial insight into the cellular roots of neurodegeneration. He also explores the often overlooked function of oligodendrocytes, which are responsible for myleination, and the importance of the gut-brain axis. Ultimately, the course arrives at the power of redox as a functional lens through which to restore brain homeostasis and potentially prevent or offset neurodegeneration and loss of cognitive function that accompanies Parkinson’s , Alzheimer’s, and Multiple Sclerosis. In addition, Dr. Seeds outlines a unique, comprehensive framework that clinicians can apply in their practice to both address neurodegenerative disease and optimize cognitive function – as well as overall patient healthspan. Through these immersive lessons, you will gain a systems-level understanding of key cellular players (neurons, microglia, astrocytes, oligodendrocytes), mitochondrial networks, redox dynamics, neuroimmune crosstalk, and clinical protocols.
What's Included
This course is organized as themed, recorded lessons that move from core mechanisms of neurocognitive dysfunction into clinician-facing frameworks for evaluation and follow-up. The structure supports stepwise learning, with repeated attention to evidence limitations and how to interpret findings over time.
- 20h 33m total runtime
- 8 modules
- 32 lessons
- Downloadable learning guides
- Eligible for 14.00 AMA PRA Category 1 Credits™ with purchase of additional add-on
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the co-sponsorship of Northeast Ohio Medical University and Seeds Scientific Research and Performance Institute. Northeast Ohio Medical University is accredited by the ACCME to provide continuing education for physicians. Northeast Ohio Medical University designates this live activity and enduring material activity for a maximum of 14.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 
William Seeds
MD
For over 40 years, Dr. William A. Seeds has dedicated his career to studying cellular and molecular pathways within the human body. As Founder of both the SSRP Institute and Redox Medical Group, he leads the field in Cellular Medicine and Epigenetics by bringing cutting-edge research to the forefront of patient care, optimizing cellular efficiency, and addressing the root causes of diseases.
Watch highlights from Mastermind 14
Course Curriculum
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Energy Crisis in Neurons |
|
54 min | |
| Redox Signaling and Neurotransmitter Imbalance |
|
54 min | |
| Loss of Synaptic Plasticity and the CDREB-BDNF Axis |
|
1 hr 22 min | |
| Neuronal Bioenergetics as Therapeutic Targets |
|
41 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Microglia Phenotypes: Guardians or Executioners? |
|
35 min | |
| Mitochondrial Dysfunction in Microglia |
|
42 min | |
| Immune Cell Crosstalk in the CNS |
|
30 min | |
| Reprogramming Microglia to Restore Homeostasis |
|
37 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Astrocytic Glutamate Clearance and Excitotoxicity |
|
16 min | |
| Astrocyte-Neuron Lactate Shuttle (ANLS) |
|
22 min | |
| Neurovascular Unit and BBB Maintenance |
|
12 min | |
| Targeting Astrocyte Function in Therapy |
|
20 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Oligodendrocyte Development and Myelin Maintenance |
|
1 hr 2 min | |
| Lipid Metabolism and Myelin Integrity |
|
1 hr 21 min | |
| Oligodendrocyte Mitochondria and ROS Susceptibility |
|
46 min | |
| Clinical Restoration of Myelin Function |
|
1 hr 35 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Neurogenesis in the Adult Brain |
|
36 min | |
| CREB-BDNF Axis and Memory Encoding |
|
20 min | |
| Rewiring via Experience and Stimuli |
|
16 min | |
| Cellular Medicine Protocols for Synaptic Restoration |
|
41 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Microbiome: Microglia Signaling Pathways |
|
32 min | |
| Vagal Nerve and Cholinergic Reflex Loop |
|
24 min | |
| Leaky Gut, Leaky Brain: The Barrier Connection |
|
21 min | |
| Therapeutic Targeting of the Gut–Brain Interface |
|
25 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Insulin Resistance in the Brain |
|
13 min | |
| Ketones, NAD⁺, and Brain Energy Shifts |
|
20 min | |
| Sirtuins and Epigenetic Remodeling |
|
23 min | |
| Integrated Cellular Reprogramming Strategies |
|
52 min |
| Status | Lesson Title | Speaker | Duration |
|---|---|---|---|
| Clinical Phenotyping of Cognitive Decline |
|
40 min | |
| Cellular Pathway Diagnostics and Biomarkers |
|
1 hr 2 min | |
| Multi-Target Protocols and Case Studies |
|
23 min | |
| Future Technologies and Neurorestoration Frontiers |
|
52 min |
Eligible for 14.0 AMA PRA Category 1 Credits™
In Partnership With
Optional Add-On
Mastermind 14: The Brain Code - CME Package
CME credit is provided through this optional add-on, purchased separately. Course registration alone does not include CME credit.
Add Course + CME Package — $1,195.00