Mastermind 5: Brain Health

In this follow up mastermind devoted to enhancing neurocognition and lessening the risks of neurodegenerative disease, Dr. Seeds once again focuses on cellular energy metabolism and oxidative stress regulation (“redox balance”) as a crucial lens through which to understand brain functioning. You will learn how brain-derived neurotrophic factor (BDNF) signaling can shift based on inflammation, metabolism, and protein processing, and how this connects to synaptic plasticity and neurodegenerative risk. The 6 lessons also address glycation (“sugar damage”), membrane lipid biology, and vascular–brain interface concepts such as endothelial function, blood–brain barrier integrity, and glymphatic clearance. Throughout, the course will help you apply mechanistic science to your clinical practice, including how to think about selected biomarkers, imaging, and genetic risk scoring. This approach aims to inform individualized evaluation and longitudinal follow-up in complex neurocognitive and brain-performance-adjacent cases by helping clinicians identify plausible contributors to symptoms and monitor patient progress. In addition, Dr. Seeds offers substantive strategies for improving outcomes, including the roles of nutrition, exercise, peptides, small molecules, and supplements.  The course is designed for clinicians and advanced health professionals, as well as trainees and researchers, who want to deepen their understanding of the cellular roots of neurodegenerative disease. 

The course is delivered as recorded, long-form lessons that prioritize mechanism-first teaching and clinical interpretation. Concepts are reinforced through intermittent Q&A and case-based discussion to help learners connect pathways to evaluation and monitoring considerations.

• Over 10 hours of video content
• 2 modules
• 6 lessons
• Downloadable learning guides