Mastermind 11: Microbiome 2.0

In this mastermind, Dr. Seeds offers an additional deep dive into the importance of the microbiome as a critical component of overall health and wellbeing. Through the lens of immuno-metabolism, he shows how the microbiome consists of trillions of microbes that live in and on the body, and that the gut, specifically, contains over 1,000 species of bacteria. This system affects not only digestion but also immune function and mental health. Its biggest disruptor is dysbiosis, which can be caused by a range of factors, including, a low fiber/high processed food diet; disruption of circadian rhythm; antibiotics; alcohol consumption; and environmental toxins, among others. Through a careful overview of reliable interventions, Dr. Seeds identifies peptides, supplements, and other strategies for restoring gut health and balance. Across 8 lessons, you will review the underlying cellular pathways involved in gut balance and learn how to interpret the impacts of oxidative stress, dangers of synthetic antioxidants, and the high costs of the combination of poor diet and little exercise. Key themes include SCFA ecology, tryptophan routing (serotonin vs kynurenine vs microbial indoles), bile-acid physiology and receptor signaling, and how inflammation can shift gut ecology in ways that change clinical interpretation. The course also highlights diagnostic and evidence constraints in areas clinicians frequently face, such as SIBO breath testing and mixed nutrition or supplement data. The goal of the course is to develop a clear cellular medicine-based framework to interpret microbiome-related findings, monitor relevant clinical or laboratory results, and apply individualized reasoning for complex cases where one-size-fits-all approaches often fall short.

The course is organized as a two-day, multi-part lecture and discussion that builds a mechanistic framework for interpreting microbiome function through clinically relevant metabolites and signaling concepts. It emphasizes how to translate these concepts into practical clinical reasoning while noting common limitations in testing and evidence.

• Over 15 hours of video content
• 2 modules
• 8 lessons
• Downloadable learning guides