Mastermind 2: Neurogenic Pain

This early mastermind offers an 8-lesson overview of the cellular roots of neurodegenerative disease, first focusing on cellular senescence and redox disruption. From there, Dr. Seeds develops a cellular and neuroimmune framework to explain how neuroinflammation develops and impacts a wide cross-section of cellular pathways. You’ll learn how mitochondrial stress, senescence, inflammasome signaling, and sleep/circadian factors connect to both disease and neurogenic pain. By looking closely at how injury-related pain can become “neurogenic,” where nerve signaling and immune signaling reinforce each other and may persist even after the tissue looks healed, Dr. Seeds and other experts discuss the predictable patterns in joint degeneration and neuropathic or neurogenic pain. The course also includes case vignettes and helpful Q&A segments that explore how clinicians think through peptide and medication choices in complex cases (e.g., MS, neuropathy, vagus nerve injury), with repeated emphasis that there is no single “one-size-fits-all” solution. The goal of the course is to help you interpret complex presentations with a clearer upstream-to-downstream model, without relying on one-size-fits-all protocols to support individualized care. The course is designed for clinicians working with complex pain and degenerative conditions, and for trainees or researchers who want a mechanistic bridge between cellular medicine concepts and real-world patient scenarios.

The course is organized as a mechanism-first teaching series followed by applied Q&A and case-based discussion that connects cellular models to common pain presentations. It is designed to support clinical reasoning and longitudinal reassessment rather than provide a fixed protocol.

• Over 15 hours of video content
• 2 modules
• 8 lessons
• Downloadable learning guides