Mastermind 8: Cellular Senescence

In this deep dive into cellular senescence, Dr. Seeds unpacks the intricacies of immunosenescence; why senescence is both good and bad; and how understanding these cellular mechanisms offers us a robust lens through which to understand aging. Along with a guest, Patrick Bradshaw, PhD, Dr. Seeds explains how senescent cells develop and, if unchecked, can create numerous negative downstream effects. When cells stop dividing yet remain biologically active, they can contribute to chronic inflammatory signaling and create havoc, affecting mitochondrial energy stress, nutrient sensing, and changes in immune surveillance, including the brain-gut–immune interface. Further, the course delves into the epigenetic influences on senescent processes. The 6 lessons also review what senescence markers and pathways can and cannot tell you, and why tissue context matters when discussing senolytics or senomodulators as therapeutic levers. Throughout the course there is an emphasis on tracking senescence to optimize therapeutic protocols.

The course is organized as a stepwise progression from core mechanisms of senescence to integrative clinical interpretation and monitoring concepts. It revisits key ideas across sessions to reinforce an upstream-to-downstream model you can use for longitudinal follow-up and reassessment.

• Over 5 hours of video content
• 2 modules
• 6 lessons
• Downloadable learning guides