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GLP-1 and the Gut–Musculoskeletal Axis: A Clinical Summary

GLP-1 and the Gut–Musculoskeletal Axis: A Clinical Summary

by William Seeds, MD | Jun 3, 2026 | Article

The Overlooked Connection: Dysbiosis and Degenerative Disease Degenerative musculoskeletal diseases, including osteoarthritis (OA), osteoporosis (OP), sarcopenia (SP), and intervertebral disc degeneration (IVDD), affect well over a billion people globally and share...
How the Peptide AOD-9604 Targets LanCL Proteins to Fight Viral Infections and Neurodegenerative Conditions 

How the Peptide AOD-9604 Targets LanCL Proteins to Fight Viral Infections and Neurodegenerative Conditions 

by William Seeds, MD | May 14, 2026 | Article

In this research article, I return to the subject of my first-ever Journal Club (Ep. 017), in which I discussed a 2023 research study entitled, “Naturally derived cytokine peptides limit virus replication and severe disease during influenza A virus infection”...
A Review of Circadian Processes and Evidence-Based Interventions to Improve Sleep

A Review of Circadian Processes and Evidence-Based Interventions to Improve Sleep

by William Seeds, MD | Apr 21, 2026 | Article

Introduction In March of this year, I did a Rabbit Hole (Episode 079) in which I discussed a number of trends marketed to the wider public promising sleep improvement. As you know, a huge swath of the population suffers from sleep disturbance. According to the NIH,...
The Truth about Ketone Esters: Not All Exogenous Products are the Same

The Truth about Ketone Esters: Not All Exogenous Products are the Same

by William Seeds, MD | Mar 25, 2026 | Article

The Father of Ketones and the Value of Exogenous Ketone Esters I’ve talked about ketones and ketone esters for many years, and I’ve now come to a place  where I really have to take a more direct stand on how they’ve been marketed to the wider public,...
The Role of Spermidine and Endothelial Regeneration

The Role of Spermidine and Endothelial Regeneration

by William Seeds, MD | Feb 26, 2026 | Article

Recently I presented a Rabbit Hole (1/19/2026) related to the polyamine, spermidine, in response to a 2025 article, “Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis,” which appeared in Nature Cell Biology. I was...
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